Fine structure of lymphocystis virus of fish

Walker, Roland

doi:10.1016/0042-6822(62)90047-8

Cited by 77 publications

(28 citation statements)

References 2 publications

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“…The findings in ultra-thin sections of infected cells consensused well with those of previous investigations [20][21][22][23] . In addition, they showed more detail of the virus shell and possibly a morphological substrate for the osmiophilia and the other-sensitivity of the virus [18,24] .…”

Section: Discussionsupporting

confidence: 90%

Histopathological study of lymphocystis disease virus (LCDV) in cultured false clownfish, Amphiprion ocellaris (Cuvier, 1830) and true clownfish, Amphiprion percula (Lacepede, 1802)

2014

JCLM

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Section: Discussionsupporting

confidence: 90%

Histopathological study of lymphocystis disease virus (LCDV) in cultured false clownfish, Amphiprion ocellaris (Cuvier, 1830) and true clownfish, Amphiprion percula (Lacepede, 1802)

2014

JCLM

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“…The lymphocystis disease virus (LCDV) has been studied by a series of morphology and ultrastructure observations (2,3,15,27,36,47), molecular characterization analysis (5,7,9,12,29,30), and attempts at in vitro infection and propagation (25,35,38,46). LCDV has been identified as an iridovirus (7,39) and is distributed worldwide.…”

mentioning

confidence: 99%

Complete Genome Sequence of Lymphocystis Disease Virus Isolated from China

Zhang

Xiao

Xie

et al. 2004

J Virol

125

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Lymphocystis diseases in fish throughout the world have been extensively described. Here we report the complete genome sequence of lymphocystis disease virus isolated in China (LCDV-C), an LCDV isolated from cultured flounder (Paralichthys olivaceus) with lymphocystis disease in China. The LCDV-C genome is 186,250 bp, with a base composition of 27.25% G؉C. Computer-assisted analysis revealed 240 potential open reading frames (ORFs) and 176 nonoverlapping putative viral genes, which encode polypeptides ranging from 40 to 1,193 amino acids. The percent coding density is 67%, and the average length of each ORF is 702 bp. A search of the GenBank database using the 176 individual putative genes revealed 103 homologues to the corresponding ORFs of LCDV-1 and 73 potential genes that were not found in LCDV-1 and other iridoviruses. Among the 73 genes, there are 8 genes that contain conserved domains of cellular genes and 65 novel genes that do not show any significant homology with the sequences in public databases. Although a certain extent of similarity between putative gene products of LCDV-C and corresponding proteins of LCDV-1 was revealed, no colinearity was detected when their ORF arrangements and coding strategies were compared to each other, suggesting that a high degree of genetic rearrangements between them has occurred. And a large number of tandem and overlapping repeated sequences were observed in the LCDV-C genome. The deduced amino acid sequence of the major capsid protein (MCP) presents the highest identity to those of LCDV-1 and other iridoviruses among the LCDV-C gene products. Furthermore, a phylogenetic tree was constructed based on the multiple alignments of nine MCP amino acid sequences. Interestingly, LCDV-C and LCDV-1 were clustered together, but their amino acid identity is much less than that in other clusters. The unexpected levels of divergence between their genomes in size, gene organization, and gene product identity suggest that LCDV-C and LCDV-1 shouldn't belong to a same species and that LCDV-C should be considered a species different from LCDV-1.

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“…Two, possibly 3 viruses, are associated with infections of the integument. The first to be described and isolated was lymphocystis virus, a cause of cellular hypertrophy in the integument of many species of freshwater and marine fish (Walker 1962, Wolf et al 1966). The second iridovirus was associated with the s h n of Atlantic cod, Gadusmorhua, with ulcer disease (Jensen et al 1979).…”

Section: Introductionmentioning

confidence: 99%

An iridovirus infection of the integument of the white sturgeon Acipenser transmontanus

Hedrick¹,

Groff²,

McDowell³

et al. 1990

Dis. Aquat. Org.

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ABSTRACT. A newly recognized iridovirus was found to be infecting the integument of the juvenile white sturgeon Acipenser transmontanus. Only epithelia1 cells in the skin and gills were infected.Infected cells were enlarged and often very basophilic. Virions with a mean diameter of 262 nm were found within infected cells. In heavy infections, the skin and gills of dead and moribund fish showed numerous infected cells. No other pathogens were detected in sturgeon that succumbed to the disease, and it is likely that the virus was the ca.use of the mortality. A laboratory study indicated that the vlrus could be transmitted via water to uninfected white sturgeon held below infected fish.

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Fine structure of lymphocystis virus of fish

Cited by 77 publications

References 2 publications

Histopathological study of lymphocystis disease virus (LCDV) in cultured false clownfish, Amphiprion ocellaris (Cuvier, 1830) and true clownfish, Amphiprion percula (Lacepede, 1802)

Histopathological study of lymphocystis disease virus (LCDV) in cultured false clownfish, Amphiprion ocellaris (Cuvier, 1830) and true clownfish, Amphiprion percula (Lacepede, 1802)

Complete Genome Sequence of Lymphocystis Disease Virus Isolated from China

An iridovirus infection of the integument of the white sturgeon Acipenser transmontanus

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