Fine structure and morphogenesis of asteroid hyalosis

Komatsu, Hironori; Kamura, Yumi; Ishi, Kuniko; Kashima, Yoji

doi:10.1007/s00795-002-0211-y

Cited by 23 publications

(12 citation statements)

References 11 publications

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“…As asteroid hyalosis is mostly an incidental finding, it would be surprising if it were not statistically associated with conditions that commonly prompt an eye examination (Khoshnevis et al 2019). The composition of the asteroid bodies is dominated by lipid complexes containing calcium, phosphates and oxygen (Streeten 1982;Topilow et al 1982;Miller et al 1983), which has prompted speculation that they may be formed by mechanisms that are also involved in cholelithiasis and nephrolithiasis (Komatsu et al 2013).…”

Section: Referencesmentioning

confidence: 99%

Global prevalence of asteroid hyalosis and projection of its future burden: a systematic review and meta‐analysis

Møller-Lorentzen

Eckmann-Hansen

Faber

et al. 2020

Acta Ophthalmologica

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Asteroid hyalosis is defined by the presence of white, snowball‐like non‐crystalline vitreous opacities that move with the vitreous and appear to be anchored to its matrix. Asteroid hyalosis commonly occurs in the absence of other identifiable ocular abnormalities and is usually an incidental finding. The vitreous opacities are usually invisible to the patient and asymptomatic, but asteroid hyalosis can be a significant obstacle to the examination of the fundus. The prevalence increases dramatically with age. The aetiology is unknown. We systematically reviewed the literature for epidemiological data, qualitatively reviewed available studies, conducted meta‐analyses with demographical stratifications, evaluated temporal changes and estimated the future prevalence using forecasting analysis. Nine eligible studies were identified with data on 104 569 individuals. The overall population prevalence of asteroid hyalosis was 0.75% (95% confidence interval: 0.39–1.21%); however, the prevalence was highly age‐dependent, ranging from 0.27% (95% confidence interval 0.12–0.49%) in individuals aged 0–39 years and gradually increasing to 3.07% (95% confidence interval 1.90–4.50%) in individuals aged ≥80 years. Male gender was an additional risk factor (odds ratio 1.80, 95% confidence interval 1.32–2.45, p = 0.00017). The estimated global prevalence was 10.7 million subjects in year 1950, which is expected to increase to 41.5 million in year 2020 and 91.2 million in year 2100. The prevalence of asteroid hyalosis is relevant because it impacts the utility of diagnostic strategies, especially screening methods for conditions such as diabetic retinopathy.

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Section: Referencesmentioning

confidence: 99%

Global prevalence of asteroid hyalosis and projection of its future burden: a systematic review and meta‐analysis

Møller-Lorentzen

Eckmann-Hansen

Faber

et al. 2020

Acta Ophthalmologica

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“…Representative photograph of one ABs specimen suspended within the vitreous humor and Raman spectra of two ABs specimens from both AH patients, and β-carotene as well as lutein [133]. cidated, although several techniques had been attempted to investigate their structure and composition [134][135][136]. Until now, the structural compositions of ABs had been proposed to consist of calcium hydroxyapatite, sphingomyelin, triglyceride, cholesterol, ceramide dihexoside, cerebroside sulfate, proteoglycans, and glycosaminoglycan in the vitreous humor.…”

Section: Corneal Calcification [131]mentioning

confidence: 99%

FT‐IR and Raman vibrational microspectroscopies used for spectral biodiagnosis of human tissues

Lin¹,

Li²,

Cheng³

2007

Journal of Spectroscopy

105

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Fourier transform infrared (FT-IR) and Raman vibrational microspectroscopies used for biomedical diagnosis of human tissues are reviewed from basic principle to biological applications. The advantages and disadvantages of both vibrational microspectroscopies are compared to highlight their efficiency and adaptability for noninvasively investigating the chemical compositions of ultrastructual human tissues at different disease states. Biochemical fingerprints applied to the biological samples by using FT-IR and Raman microspectroscopies are illustrated. The spectral biodiagnoses of several diseased human tissues such as ophthalmic disorders (risk factors-induced cataractous lens capsules and lens, lens and corneal calcifications, opacification and contamination of intraocular lens, vitreous asteroid bodies), alcohol-disordered human gastric mucosa, skin disorders (cancer and calcification), brain tumors (pituitary adenomas and astrocytomas), genetic hair roots disorder (glucose-6-phosphate dehydrogenase deficiency, phenylketonuria and congenital hypothyroidism), benign prostatic hyperplasia, and interstitial cystitis investigated by both vibrational microspectroscopies in our laboratory are introduced.

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“…The origin, composition, and formation of ABs in the vitreous are still incompletely elucidated, although several techniques such as biochemical methods, phase-contrast microscopy, electron microscopy, and electron-dispersive X-ray spectroscopy have been attempted to investigate their structure and composition~Feldman, 1967;Topilow et al, 1982;Streeten, 1982;Miller et al, 1983;Winkler & Lunsdorf, 2001; Komatsu et al, 2003!. Until now, the structural compositions of ABs have been proposed to consist of calcium hydroxyapatite, sphingomyelin, triglyceride, cholesterol, ceramide dihexoside, cerebroside sulfate, proteoglycans, and glycosaminoglycan in the vitreous humor.…”

Section: Introductionmentioning

confidence: 99%

Preliminary Identification of β-Carotene in the Vitreous Asteroid Bodies by Micro-Raman Spectroscopy and HPLC Analysis

et al. 2007

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beta-carotene was first identified from the vitreous asteroid bodies (ABs) excised from one patient with asteroid hyalosis (AH) by confocal Raman microspectroscopy and was also verified by high performance liquid chromatography (HPLC). Two patients had been diagnosed with AH and intervened by surgical vitrectomy due to blurred vision. The morphology and components of both AB specimens were observed by optical microscopy and determined by using confocal Raman microspectroscopy and HPLC analysis, respectively. Surprisingly, two unique peaks at 1528 and 1157 cm(-1) were found in the Raman spectrum for the AB specimen of patient 1 alone, which were in close agreement with that of the Raman peaks at 1525 and 1158 cm(-1) for beta-carotene and/or lutein. However, HPLC analytical data clearly indicated that the retention time for the extracted sample from the AB specimen of patient 1 was observed at 13.685 min and just identical to that of beta-carotene (13.759 min) rather than lutein (2.978 min). In addition, the lack of any peak in the HPLC profile for the AB specimen of patient 2 also confirmed the absence of Raman peaks at 1525 and 1158 cm(-1). Thus this preliminary study strongly suggests that beta-carotene as a unique component of ABs was specifically detected from the AB specimen of one AH patient by using confocal Raman microspectroscopy and HPLC analysis.

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Fine structure and morphogenesis of asteroid hyalosis

Cited by 23 publications

References 11 publications

Global prevalence of asteroid hyalosis and projection of its future burden: a systematic review and meta‐analysis

Global prevalence of asteroid hyalosis and projection of its future burden: a systematic review and meta‐analysis

FT‐IR and Raman vibrational microspectroscopies used for spectral biodiagnosis of human tissues

Preliminary Identification of β-Carotene in the Vitreous Asteroid Bodies by Micro-Raman Spectroscopy and HPLC Analysis

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