Fine Needle Aspiration of Gastrointestinal Stromal Tumors

Li, Sherry Q.; O’Leary, Timothy J.; Buchner, Sally-Beth; Przygodzki, Ronald M.; Sobin, Leslie H.; Erozan, Yener S.; Rosenthal, Dorothy L.

doi:10.1159/000327181

Cited by 54 publications

(45 citation statements)

References 17 publications

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“…These findings were supported by the histologic sections in which GISTs consisted of broad bundles, interlacing fascicles, or occasionally whorls of spindle or oval cells with a high cellular density and overall basophilic appearance at low magnification. In Li et al study (17) in which histologic analysis was not performed in about 1/3 of cases, benign and borderline GISTs tended to have cells arranged in tightly cohesive clusters. Malignant GISTs were more likely to exhibit loosely cohesive groups with many single cells, but in the present study all GISTs including eight malignant and one UMP occurred characteristically in closely packed cohesive tissue fragments with a high cellular density.…”

Section: Discussionmentioning

confidence: 98%

“…Although there have been only a few case reports and series of cases published (14)(15)(16)(17)(18)(19), every diagnosis was not supported by c-kit immunostain (18,19), cytohistologic correlation (16), and histologic diagnoses (16,18). Most of the cases were not correlated with follow-up data (14,17,18). Until recently, GIST treatment consisted of a surgical resection followed by surveillance for metastatic disease.…”

Section: Introductionmentioning

confidence: 99%

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Fine Needle Aspiration Cytology (FNAC) of Gastrointestinal Stromal Tumor: An Emphasis on Diagnostic Role of FNAC, Cell Block, and Immunohistochemistry

Kwon¹,

Koh²,

Lee³

et al. 2002

J Korean Med Sci

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Recently the origin of gastrointestinal stromal tumors (GISTs) is thought be the interstitial cells of Cajal or primitive stem cells. This study was performed to evaluate the roles of fine needle aspiration cytology (FNAC), cell block preparation, and immunohistochemistry in the diagnosis of GISTs. Nine cases of GIST in which FNAC was performed were included in this study. Cytologically, the tumor cells characteristically occurred in closely packed cohesive tissue fragments with high cellular density often in bloody background. The tumor cells often formed fascicles with parallel, side-by-side arrangements of the nuclei. Histologically, GISTs were highly cellular spindle or epithelioid tumor with basophilic appearance. Immunohistochemically, GISTs were c-kit positive in all of nine cases, CD34 positive in seven, focally SMA positive in two, and S-100 and GFAP negative in all. Both histologic and cell block sections showed the same histologic and immunohistochemical features. Cytomorphologically GISTs show a broad morphologic spectrum but rarely a significant nuclear pleomorphism and the assessment of malignant potential is difficult based on cytology alone. However, in the appropriate clinical and radiologic setting, a confident diagnosis of primary or metastatic GIST can be established by FNAC, cell block, and immunohistochemistry.

show abstract

Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Fine Needle Aspiration Cytology (FNAC) of Gastrointestinal Stromal Tumor: An Emphasis on Diagnostic Role of FNAC, Cell Block, and Immunohistochemistry

Kwon¹,

Koh²,

Lee³

et al. 2002

J Korean Med Sci

View full text Add to dashboard Cite

show abstract

“…The cytological studies on GIST in literature are not comparable as many of the earlier published cytologic studies have combined GIST into a group of neoplasms encompassing leiomyoma, schwannoma, leiomyosarcoma, and an epithelioid leiomyoblastoma [2,5]. However recently, few authors have established EUS-FNAC as a reliable method for diagnosing GIST and EGIST before surgical procedure [3,6].…”

Section: Discussionmentioning

confidence: 99%