Fine Needle Aspiration Cytopathology of Primary Solid Adenoid Cystic Carcinoma of the Lung

Özkara, Sevgiye Kaçar; Turan, Gupse

doi:10.1159/000325416

Cited by 12 publications

(8 citation statements)

References 8 publications

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“…Cytologic diagnosis of primary ACC of the lung has been rarely discussed in the literature 5–8. To our knowledge, all of them originated from the extrapulmonary airway or bronchus, unlike this case.…”

Section: Discussionmentioning

confidence: 76%

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Primary peripheral pulmonary adenoid cystic carcinoma: Report of a case diagnosed by fine needle aspiration cytology

Chon

Park

et al. 2011

Diagnostic Cytopathology

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Adenoid cystic carcinoma (ACC) arising from anatomic sites other than the salivary gland is rare and those occurring in the lung are extremely rare. When arising from the lung, the tumor generally arises from extrapulmonary bronchi, originating from bronchial glands. Primary ACC of the lung located peripherally within lung parenchyma is an even rarer event. To the best of our knowledge, this is the first case of primary peripheral pulmonary ACC preoperatively diagnosed by fine needle aspiration cytology (FNAC). We report a case of primary peripheral ACC of the anterior segment of the right upper lobe in a 46-year-old woman diagnosed by FNAC and a brief review of the literature.

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Section: Discussionmentioning

confidence: 76%

“…They had made the diagnosis of ACC using bronchial brushings 6, 7. Similary, Qiu and Özkara et al5, 8 reported bronchoscopy‐guided FNAC of primary ACC of the lung. Both of them also arose from the main bronchus.…”

Section: Discussionmentioning

confidence: 99%

Primary peripheral pulmonary adenoid cystic carcinoma: Report of a case diagnosed by fine needle aspiration cytology

Chon

Park

et al. 2011

Diagnostic Cytopathology

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“…Pulmonary ACC may sometimes be mimicked by reserve cell hyperplasia, well‐differentiated adenocarcinoma, small‐cell undifferentiated carcinoma, and carcinoid tumour . The hyperplastic bronchial cells are cuboidal to columnar and smaller than the neoplastic cells of ACC bearing cilia or terminal bars.…”

Section: Discussionmentioning

confidence: 99%

Adenoid cystic carcinoma: A study of 19 cases of salivary and extra‐salivary tumours diagnosed by fine needle aspiration cytology

Kundu

Handa

Punia

et al. 2018

Diagnostic Cytopathology

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Background Adenoid cystic carcinoma (ACC) arises at sites where seromucinous or sweat gland epithelium is present and commonly affects the salivary glands. Rarely it can occur at extra‐salivary locations. Methods A retrospective analysis of 19 cases of ACC diagnosed on fine needle aspiration cytology (FNAC) over a period of 15 y (2002‐2016) was made. Results Of 19 total cases, there were 10 salivary and 9 extra‐salivary ACCs. Extra‐salivary tumours were seen in 2 cases each in trachea, tongue and in one case each in bronchus, lung, subcutaneous tissue, maxillary antrum, and external auditory canal. The age ranged from 14‐80 y (mean: 49.5 y), 10 patients were male and 9 were female. The smears were highly cellular in 11 cases, moderately cellular in 5 cases while 3 cases were paucicellular. Multilayered dense clusters, tissue fragments, dispersed cells and cup‐shaped fragments were seen. Relatively uniform cells with high nuclear: cytoplasmic ratio, hyperchromatic nuclei, irregular margins, and nuclear moulding were observed. Variable sized hyaline globules, finger‐like hyaline material, hyaline cylinders, and hyaline cords were noted. The cytologic diagnosis of ACC was rendered in 13 cases while in 6 cases it was one of the differential diagnosis including monomorphic adenoma, membranous variant of basal cell adenoma, adnexal tumour, polymorphous adenocarcinoma, and pleomorphic adenoma (PA). Conclusions Cytologists must be aware of varied locations where ACC can occur. A diagnosis of ACC must not rely exclusively on the occurrence of hyaline globules but necessitates a close scrutiny of cellular and nuclear features to avoid diagnostic pitfalls.

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“…Bronchial brushings have been reported to be useful for the diagnosis of primary ACCs of the lung arising from the trachea and the main bronchus [25,26]. Similarly, bronchoscopy-guided FNAC may be used to diagnose primary lung ACC arising from the main bronchus [6,27]. Although primary peripheral ACC of the lung rarely occurs, a preoperative accurate diagnosis should be made in cases where appropriate cytologic smears can be obtained for clinicians to provide appropriate treatment for the patient.…”

Section: Discussionmentioning

confidence: 99%

Primary adenoid cystic carcinoma in the peripheral lung: a cytological, histopathological and immunohistochemical report of two cases

Etori¹,

Watanabe²,

Matsuyama³

et al. 2015

Pathol Discov

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Primary adenoid cystic carcinoma (ACC) of the peripheral lung is a rare entity. Here we report two cases of primary ACC. Case 1 is an 84-year-old male with a past-medical history of cecal cancer presented with a 10 mm left upper lung nodule. Case 2 is a 40-year-old female who presented with 30 mm right upper lobe. Intraoperative (Case 1) and pre-operative (Case 2) histopathologic and cytologic diagnoses were consistent with a primary peripheral lung ACC. An upper lobectomy±mediastinal lymph node dissection was performed and immunohistochemical staining with thyroid transcription factor (TTF)-1, c-KIT and MYB on the excision specimen confirmed our diagnosis. carcinoma in the peripheral lung: a cytological, histopathological and immunohistochemical report of two cases. Pathol Discov. 2015; 3:3. http://dx.

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Fine Needle Aspiration Cytopathology of Primary Solid Adenoid Cystic Carcinoma of the Lung

Cited by 12 publications

References 8 publications

Primary peripheral pulmonary adenoid cystic carcinoma: Report of a case diagnosed by fine needle aspiration cytology

Primary peripheral pulmonary adenoid cystic carcinoma: Report of a case diagnosed by fine needle aspiration cytology

Adenoid cystic carcinoma: A study of 19 cases of salivary and extra‐salivary tumours diagnosed by fine needle aspiration cytology

Primary adenoid cystic carcinoma in the peripheral lung: a cytological, histopathological and immunohistochemical report of two cases

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