Fine needle aspiration cytology versus histopathology in diagnosing lymph node lesions

Alwan, Nada A. Al; Hashimi, Amer S. Al; Salman, M. M.; Attar, Esam A. Al

doi:10.26719/1996.2.2.320

Cited by 9 publications

(4 citation statements)

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“…This was higher than Landgren’s study which found an accuracy of 73.8% [13]. Our results are consistent with those of Keith et al ( 3 ), Al-Mulhim et al ( 7 ) and Al-Alwan et al ( 14 ), who reported diagnostic accuracy of 82%, 86% and 88.5% for non-Hodgkin lymphoma cases, respectively. Yu et al conducted a comprehensive review encompassing 31 studies published in both Chinese and English.…”

Section: Discussionsupporting

confidence: 90%

Fine Needle Aspiration Cytology of Lymph Nodes in Metastatic Cancer and Lymphoma: Our Single-institution Experience

Vesnic,

Joguncic,

Sarajlic

et al. 2024

Mater Sociomed

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Background: Lymphadenopathy is a common finding in clinical practice. The cause of enlarged nodes on clinical examination alone is challenging and there may be multiple reasons for this enlargement. It may become enlarged due to stimulation by infectious agents or the involvement of metastasis or malignant diseases, such as lymphoma. Objective: The aim of the study was to investigate the diagnostic role of fine needle aspiration cytology of lymph nodes in metastatic cancer and lymphoma. Methods: A total of 48 FNAC lymph nodes suspicious for malignancy were sampled with follow-up biopsy in Clinical Center of University of Sarajevo from 2017 to 2023. Lymph nodes were aspirated using 20-22 G needle with minimally 2 passes, spread on slides, air-dried, stained with May-Grünwald-Giemsa or Papanikolaou and residual material sent for cytoblock. Results: Out of 48 cytological samples, 30 (62.5%) revealed metastatic epithelial cells and 12 (25%) lymphoproliferative neoplasm. Three samples were suspected for malignancies, one sample was unrepresentative, one inconclusive and one falsely negative. Histopathological confirmation had 35 patients, while others were confirmed based on clinical presentation and radiological techniques. Compared to histopathological diagnosis, cytology had a sensitivity of 89.47%, specificity of 93.33%, positive predictive value (PPV) 95.04% and negative predictive values (NPV) 86.13% for epithelial metastatic cancer. The overall diagnostic test accuracy was 91.06%. For lymphoproliferative neoplasms cytology in comparison to histopathology had sensitivity 85.71%, specificity 91.18%, PPV 76.4% and NPV 95.04%. The overall diagnostic test accuracy was 89.81%. In both ways cytology is showing significant possibility to be used as a primary tool in detecting cancers. Conclusion: FNAC is a fast, reliable, and efficient method for diagnosing malignant lymphadenopathy. The cytological diagnosis can sometimes be accepted as the definitive diagnosis without further correlation with histopathology, especially in advanced malignancies and known primary malignancies.

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Section: Discussionsupporting

confidence: 90%

Fine Needle Aspiration Cytology of Lymph Nodes in Metastatic Cancer and Lymphoma: Our Single-institution Experience

Vesnic,

Joguncic,

Sarajlic

et al. 2024

Mater Sociomed

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“…A major proportion of lymphadenopathies in the study were due to benign conditions (81.66%) which was in accordance to other earlier study in which 86.4% of the lesions were benign. AL Alwan et al [4] and Narang et al [5] also showed benign lesions in 55.33% and 61.6% of the lymph nodes, respectively. Pranjali Sejwal et al [6] also showed Benign lesions were 77% and Malignant 23%.…”

Section: Discussionmentioning

confidence: 96%

Cytological evaluation of cervical lymphadenopathy in a tertiary care centre, Govt. Medical College Kathua: Two year study

Raina¹,

VM²,

Qadir³

et al. 2021

Int. J. Clin. Diagn. Pathol.

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FNAC is a well-established, reliable, quick and minimally invasive method of diagnosis in palpable masses at various sites. In developing countries like India where tuberculosis is the commonest cause of lymphadenopathy, FNAC becomes much more important tool in diagnosing the cervical lymph nodes. The present study was carried out to describe the cytomorphological patterns of cervical lymph nodes and its utility in establishing a diagnosis. All lymph node aspirates done in cytology laboratory of our department over a period of two years [September 2019 to August 2021] were included in the study. Of the total 169 cases, 68 were diagnosed as non-specific reactive lymphadenitis, 38 tubercular lymphadenitis, 23 as metastatic carcinoma, 22 acute suppurative lymphadenitis, 08 granulomatous lymphadenitis, 6 non-Hodgkins lymphoma, 01 each case of Hodgkins lymphoma, Langerhans cell histiocytosis, Kimuras disease & Rosai Dorfman disease. Fine needle aspiration can be used as first line of investigation for evaluating patients with lymphadenopathy which has proven clinical value, diagnostic accuracy, sensitivity & specificity.

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“…FNAB is characterized by a low-cost technique, relatively painless pain level and requires a fast examination time in the case of malignant lymphadenopathy. This may not only help in the primary diagnosis of tumors, but FNAB remains a useful method for following up patients with known malignancies, and even guide therapy [31].…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Test Fine Needle Aspiration Biopsy (FNAB) Examination on Gold Standard Histopathological Tests for Identification of Colli Lymphadenopathy Patients at RSPAL. Dr. Ramelan Surabaya

Andhika¹,

Handayati²,

Woelansari³

2023

International Journal of Advanced Health Science and Technology

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Lymphadenopathy is a common clinical manifestation which requires rapid and accurate diagnosis. Fine Needle Aspiration Biopsy (FNAB) is used as an initial and direct diagnosis in cases of lymphadenopathy, confirmatory diagnosis of colli lymphadenopathy is carried out by histopathological examination. The purpose of this study was to determine the value of the FNAB diagnostic test for lymphadenopathy colli FNAB against the gold standard histopathology of Paraffin Blok for benign and malignant lymphadenopathy. This type of research is observational descriptive by taking medical record data (SIM-RS) of patients with lymphadenopathy in the colli region who were examined for FNAB and histopathology at the Anatomical Pathology Laboratory Installation, RSPAL dr. Ramelan Surabaya for the period January 2019 – March 2022. The sample used was selected using the total sampling method, obtained as many as 66 samples that met the inclusion criteria. The results of the FNAB examination were then matched against the histopathological gold standard examination data. Furthermore, the data was processed by 2x2 crosstabulation and diagnostic tests were carried out to determine the sensitivity, specificity, positive predictive value, negative predictive value, and accuracy. The results showed that the accuracy of the FNAB diagnostic test was 86.56%, sensitivity 80.48%, specificity 96.15%, positive predictive value 97.05%, negative predictive value 75.75%. In general, it can be stated that the FNAB examination can be a screening diagnostic tool that is easy, fast, relatively affordable and applicable in helping to establish the diagnosis of colli lymphadenopathy.

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Fine needle aspiration cytology versus histopathology in diagnosing lymph node lesions

Cited by 9 publications

References 0 publications

Fine Needle Aspiration Cytology of Lymph Nodes in Metastatic Cancer and Lymphoma: Our Single-institution Experience

Fine Needle Aspiration Cytology of Lymph Nodes in Metastatic Cancer and Lymphoma: Our Single-institution Experience

Cytological evaluation of cervical lymphadenopathy in a tertiary care centre, Govt. Medical College Kathua: Two year study

Diagnostic Test Fine Needle Aspiration Biopsy (FNAB) Examination on Gold Standard Histopathological Tests for Identification of Colli Lymphadenopathy Patients at RSPAL. Dr. Ramelan Surabaya

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