Myositis ossificans is a reactive, ossifying process within soft tissues, which by its clinical and histological features is considered a pseudosarcomatous lesion. There are few reports that describe the cytologic findings in myositis ossificans, and each of these mentions different cellular composition. We describe the cytology of a case of myositis ossificans in a 14-year-old boy with clinical diagnosis of soft tissue sarcoma, and analyze the most common cytologic findings reported previously of this entity. We conclude that the different cellular composition reported, reflects the different histologic components of this lesion according to the area (zonation phenomenon), and that clinico-radiologic correlation is essential for the cytological diagnosis. Diagn. Cytopathol. 2008;36:50-53. ' 2007 Wiley-Liss, Inc.Key Words: myositis ossificans; scrape cytology; cytological diagnosis Myositis ossificans is a reactive, self-limiting condition characterized by prominent heterotopic ossification. It predominantly occurs deep in soft tissues, and in 50% of the cases there is relationship to injury. This lesion passes through several histologic phases. In its early phases a pseudosarcomatous lesion can be mistaken with fibrosarcoma. The intermediate phase characterized by osteoid deposition and the emergence of the zonation phenomenon can be confused with osteosarcoma of soft tissues. The late phase is characterized by the maturation of the lesion with establishment of lamellar bone and marrow fat. 1 We found only seven previous reports 2-8 with emphasis on the cytological findings of this lesion.Our work describes a case of myositis ossificans and analyzes the cytologic findings of previous reports. We make several considerations about the diagnosis by cytology in myositis ossificans.
Case ReportA 14-year-old boy was admitted to the National Orthopaedic Institute with a history of progressive pain associated with difficulty in mobilization of the hip and limitation of the march. He started 2 wk earlier, and the initial diagnosis was of a muscular injury. The pain persisted and he was treated with analgesics. There was no history of trauma.Physical examination revealed a 7-cm firm mass located in the right inguinal region associated with pain in this same region. There was a limited range of motion in the right lower extremity. On admission, the X-ray revealed only a slight increase in soft tissues, and the gammagraphy with MIBI showed a high uptake in the lesion.The clinical diagnosis was of a malignant soft tissue tumor. After 19 days an excisional biopsy was made.
Macroscopic FindingsThe surgical specimen measured 5.5 3 4 3 3 cm 3 . The lesion was well circumscribed, and it was surrounded by muscle. The margins were sharply defined and were of hard consistency. The cut surface exhibited a gray-white tissue in the central portion that was soft in consistency with focal areas of hemorrhage (Fig. 1A).An X-ray of the surgical specimen revealed a lesion calcified at the periphery (Fig. 1B).