Cytoarchitectural Findings in the Diagnosis of Primary Soft Tissue Tumors

González‐Cámpora, Ricardo

doi:10.1159/000327268

Cited by 26 publications

(28 citation statements)

References 117 publications

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“…[12] Smears in soft tissue sarcoma are cellular with atypical bizarre spindle cells, atypical mitosis and multinucleated giant cells. [13] Stitch granuloma is a benign granulomatous condition occurring in response to non absorbable suture. Cytologically, it is characterized by mixed inflammatory infiltrate, foreign body giant cells with presence of necrotic debris, fibrinous material and fragments of suture material in the background.…”

Section: Discussionmentioning

confidence: 99%

Abdominal Scar endometriosis: report of three cases with cytohistocorroboration

Arora

Tyagi²,

Nargotra³

et al. 2017

APALM

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Endometriosis of the abdominal wall scar is rare, reported incidence being 1.08% for mid-trimester abortion and 0.03-0.4% following caesarean sections. Incisional endometriosis is a relatively rare entity and is often misdiagnosed as stitch granuloma, abscess, incisional hernia, lipoma, hematoma, desmoid tumor, sarcoma, lymphoma, or primary and metastatic cancer.We report three cases of abdominal scar endometriosis; two cases occurring in the surgical scar of previous caesarean incision and one case occurring after second trimester hysterotomy.The present study describes the physical signs and symptoms and cytological features of abdominal scar endometriosis. A high index of suspicion is needed for early diagnosis of this entity in a woman presenting with post operative abdominal lump.

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Section: Discussionmentioning

confidence: 99%

Abdominal Scar endometriosis: report of three cases with cytohistocorroboration

Arora

Tyagi²,

Nargotra³

et al. 2017

APALM

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“…Cytomorphological subtyping of tumors on FNAC was done into 6 categories of myxoid, pleomorphic, spindle cell, epitheloid cell, round cell or lipomatous/well differentiated. 10 Standardized protocol for cytological grading of soft tissue sarcomas was used (Table 1). 11,12 For histological grading French federation of national cancer centre (FNCLCC) grading system was used which takes into account differentiation, mitosis and necrosis.…”

Section: Methodsmentioning

confidence: 99%

“…Cytological findings of special interest include rhabdomyoblasts, atypical lipoblasts, neuroblast rosettes and intracytoplasmic glycogen. 3,10 Categorisation is difficult because of absence of specific morphological features. In these cases, IHC, cytogenetic, molecular genetics and electron microscopy is helpful in addressing diagnostic dilemma.…”

Section: Round Cell Tumors (Rct)mentioning

confidence: 99%

Role of fine needle aspiration cytology (FNAC) in the diagnosis of soft tissue tumors

Gulzar¹,

Yasin²,

Khan³

et al. 2017

Int J Res Med Sci

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Background: Soft tissue tumors constitute a large and heterogenous group of neoplasms. Benign tumors out number their malignant counterparts by a ratio of about 100:1 in hospital population. FNAC has emerged as a major outpatient procedure for the diagnosis of soft tissue tumors due to low cost of the procedure, less complications, feasibility, quick results and high therapeutic efficiency with specificity and sensitivity of approximately 95%. The diagnostic accuracy of FNAC of soft tissue tumors in distinguishing benign and malignant lesion is also very high. The objectives of this study were to study the role of FNAC in the diagnosis of soft tissue tumors and its correlation with histopathology. Also, this study aimed at studying various cytomorphological patterns of soft tissue tumors and correlating cytological grading with histopathological grading.Methods: It was a hospital based study of 5 years which included 479 patients of all age groups, clinically presenting with soft tissue swellings. FNAC was performed. Smears were stained with Papanicolaou (PAP)/May Grunwald Geimsa (MGG). The cytological details of soft tissue tumors were studied and broadly classified into benign, malignant and indeterminate and suspicious. Cytomorphological subtyping and grading of tumors on FNAC was done. The cytological findings were correlated with the histopathological results, wherever available.Results: Benign tumors comprised of 423 cases (88.3%) and malignant tumors comprised 56 cases (11.69%)only. Maximum number of cases were seen in well differentiated/lipomatous group (339 cases) followed by spindle cell category (88 cases). Histopathological correlation carried out in 136 out of 479 cases (benign:111 and malignant :25) revealed that out of 111 cases diagnosed as benign by cytology, one case was malignant (liposarcoma) and among 25 malignant cases diagnosed by cytology one case was benign (myofibroblastoma). Overall sensitivity and specificity of FNAC was 96% and 99% respectively. Comparison of cytological and histopathological grading of 24 sarcomas showed overall concordance of 75%.Conclusions: FNAC is an excellent diagnostic modality in early diagnosis of soft tissue tumors. FNAC is highly reliable and obviates surgical procedures especially in high risk patients thus facilitating initiation of appropriate therapy and saving time and manpower. It is also highly sensitive in detecting benign soft tissue tumors and highly specific for malignant soft issue tumors.

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“…11,14 Intramuscular myxomas will show bland stellate cells in a myxoid background. 15 To exclude primary soft tissue sarcomas, one should consider clinicoradiologic correlation. High grade sarcoma usually produces a cellular smear with atypical, bizarre spindle cells, atypical mitoses and multinucleated giant cells.…”

Section: Differential Diagnosismentioning

confidence: 99%

“…High grade sarcoma usually produces a cellular smear with atypical, bizarre spindle cells, atypical mitoses and multinucleated giant cells. 11,15 Metastatic adenocarcinoma is another pitfall and can be excluded by the bland cytonuclear morphology of the glandular component of endometriosisis. 14 Metastatic carcinosarcoma is also in the differential diagnosis due to the presence of biphasic components (carcinoma and sarcoma); however, the presence of a high nuclear grade in both components excludes endometriosis.…”

Section: Differential Diagnosismentioning

confidence: 99%