Fine needle aspiration cytology of thyroid and its correlation with serological findings

Abstract

Background: Thyroid autoimmunity can cause several forms of thyroid disorders i.e. Grave's disease, Hashimoto's thyroiditis, atrophic autoimmune thyroiditis, post-partum thyroidits etc. Cytological diagnosis may be sometimes difficult is some cases. In such conditions, cytology along with serological tests aid at reaching a correct diagnosis. Hence, this study was undertaken to evaluate the serum level of anti-TPO antibody with respect to serum concentrations of thyroid hormones and its importance in diagnosing autoimmune thyroiditis. Results: Ninety-five thyroid FNAC was included in the study, which comprises of 16.8 % males and 83.2% females with a M: F 1: 4.9. Maximum number of cases was seen in the age range 21-30 years (25.3%), mean age being 40.4years. The cytological diagnosis comprised colloid goiter(43.2%), lymphocytic thyroiditis(25.3%), Hashimoto thyroiditis(18.9%). Out of 42 cases of autoimmune thyroiditis diagnosed cytologically, 16 (38%) were hypothyroid, 4 (9.5%) hyperthyroid, 8 (19%) sub-clinical hypothyroid and 14 (33.5%) were euthyroid. The sensitivity and specificity of positive anti TPO in correctly identifying autoimmune thyroiditis was 85.7% and 79.2% respectively. The positive and negative predictive value for the test was 76.5% and 87.5% respectively. Conclusion

Cytological Evaluation of Thyroid and its Correlation with Thyroid Function Test and Anti-Thyroid Peroxidase in a Patient of Hashimoto’s Thyroiditis

“…According to the study conducted in Maharajgnj, Nepal by Karki et al mean age of thyroid swelling was 40.4 years, which is in accordance to our study [14]. In the present study, the incidence of thyroid gland lesion was highest in 31-40 years age groups (39.1%) followed by 41-50 years (24.1%) and 51-60 years (14.9%) which is similar to the study done by Karki et al which showed 20-50 years as common age of thyroid gland swelling [14].…”

“…However, in contrast to present study, most patients were euthyroid in study conducted by Staii et al [13]. The sensitivity and specicity of Anti-TPO antibodies for diagnosing autoimmune thyroiditis was found to be 89.7% and 94.8% respectively which is higher compared to study conducted by Karki et al [14]. However Engler et al has reported 96% sensitivity of anti TPO antibody in autoimmune thyroiditis [19].…”

Evaluation of Different Thyroid Lesions with Fine Needle Aspiration Cytology and Thyroid Function Tests

“…This is justified by similar findings stated by Karki et al18 and Staii et al19 ,. Present study showed most commonly affected age is 41 -60 years which is comparable to the study done by Junu Devi et al17 and Poudel et al 12 .The study showed that 88% are non neoplastic lesion and 12% are neoplastic lesion whereas in study by Junu Devi et al17 , Choudhary R et al 3 and Chandanwale S et al 20 (neoplastic and non neoplastic cases were 4.55% and 94.95% respectively.…”

Diagnostic Accuracy of Anti-Thyroid Antibodies in Hashimoto’s Thyroiditis

“…7 Although many persons with Hashimoto's thyroiditis are euthyroid, significant proportion of them develop hypothyroidism eventually. 8 The prevalence of Hashimoto's thyroiditis in elderly patients is estimated to be 40%. 9 However, diagnosis relies mostly on cytology and/or histology.…”