Fine-needle aspiration cytology of sarcoma: Retrospective review of diagnostic utility and specificity

Costa, Michael J.; Campman, Steven C.; Davis, Robin L.; Howell, Lydia Pleotis

doi:10.1002/(sici)1097-0339(199607)15:1<23::aid-dc6>3.0.co;2-r

Cited by 110 publications

(83 citation statements)

References 13 publications

(8 reference statements)

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“…This might make a histological diagnosis more difficult and less accurate. Furthermore, sampling errors may occur due to the small amount of material obtained [1,4,10]. In a recent review of FNA and CNB biopsies in 359 patients with muscoloskeletal lesions the accuracy of fine needle percutaneous aspiration biopsy is reported more than 60% but significantly inferior compared to the accuracy of core needle biopsy (more than 70%) [6].…”

Section: Discussionmentioning

confidence: 99%

Percutaneous CT-guided biopsy of the spine: results of 430 biopsies

et al. 2008

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Biopsies of lesions in the spine are often challenging procedures with significant risk of complications. CT-guided needle biopsies could lower these risks but uncertainties still exist about the diagnostic accuracy. Aim of this retrospective study was to evaluate the diagnostic accuracy of CT-guided needle biopsies for bone lesions of the spine. We retrieved the results of 430 core needle biopsies carried out over the past fifteen years at the authors' institute and examined the results obtained. Of the 430 biopsies performed, in 401 cases the right diagnosis was made with the first CT-guided needle biopsy (93.3% accuracy rate). Highest accuracy rates were obtained in primary and secondary malignant lesions. Most false negative results were found in cervical lesions and in benign, pseudotumoral, inflammatory, and systemic pathologies. There were only 9 complications (5 transient paresis, 4 haematomas that resolved spontaneously) that had no influence on the treatment strategy, nor on the patient's outcome. In conclusion we can assert that this technique is reliable and safe and should be considered the gold standard in biopsies of the spine.

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Section: Discussionmentioning

confidence: 99%

Percutaneous CT-guided biopsy of the spine: results of 430 biopsies

et al. 2008

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“…[3][4][5][6][7][8][9][10][11] Some of these studies have addressed the accuracy of FNA in histologic subtyping of mesenchymal tumors. [3][4][5][6][7][8][9][10][11] The success of subtyping tumors of the musculoskeletal system has varied among studies but generally has been between 50% and 70% accurate. 6 -10, 12 Some authors have demonstrated greater accuracy of subclassification for bone neoplasms, 12 whereas others have shown significantly less success with subclassification of soft tissue neoplasms.…”

Section: Resultsmentioning

confidence: 99%

“…6 -10, 12 Some authors have demonstrated greater accuracy of subclassification for bone neoplasms, 12 whereas others have shown significantly less success with subclassification of soft tissue neoplasms. 4 Needle aspiration cytology is more successful at separating benign from malignant musculoskeletal lesions with diagnostic accuracy ranging between 80% and 95%. [3][4][5][6][7][8][9][10][11][12] This rate of diagnostic accuracy compares favorably with that achievable by cutting needle biopsy.…”

Section: Resultsmentioning

confidence: 99%

“…4 Needle aspiration cytology is more successful at separating benign from malignant musculoskeletal lesions with diagnostic accuracy ranging between 80% and 95%. [3][4][5][6][7][8][9][10][11][12] This rate of diagnostic accuracy compares favorably with that achievable by cutting needle biopsy. 13 In the study by Mankin et al, 13 major diagnostic errors were found in up to 18.2% of surgical biopsies of musculoskeletal lesions.…”

Section: Resultsmentioning

confidence: 99%

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Concordance of histopathologic and cytologic grading in musculoskeletal sarcomas

Jones

Liu²,

Hirschowitz

et al. 2002

Cancer

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“…Recent reviews on the usefulness of fine-needle aspiration cytology in the diagnosis of soft tissue tumors have yielded diagnostic specificities ranging from 21 to 97%, [1][2][3] including the use of ancillary techniques such as cell blocks for immunocytochemistry. However, the intrinsic limitations of this diagnostic method result in a general understanding that grading and histological subtyping of tumors is not always possible.…”

Section: Discussionmentioning

confidence: 99%

Successful retrieval of fine-needle aspiration biopsy material from previously stained smears for immunocytochemistry: a novel technique applied to three soft tissue tumors

et al. 2005

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Fine-needle aspiration biopsies of soft tissue tumors are often not fully diagnostic on conventional Papanicolaou or Giemsa stains. Often, more useful information can be gleaned from preparing cell blocks, which are amenable to immunocytochemistry. However, sufficiently diagnostic cell block material is not always forthcoming. We subvent this problem by employing a new 'cytoscrape' technique to create cell blocks from previously Papanicolaou-stained smear material in two cases of mesenchymal tumors where smear diagnoses were limited to 'sarcoma, not otherwise specified'. After thorough text and photographic documentation of the smear results, the slides were decolorized and tumor cells were removed for processing as for routine preparation of cell blocks. Sections cut were then submitted for immunocytochemical profiling. This resulted in definitive diagnoses in both cases, averting the need for more invasive diagnostic procedures. We applied the same technique to a third case of a lung nodule, in which the smear was inconclusive and the original cell block nondiagnostic. The subsequent immunocytochemical testing enabled a definitive diagnosis to be made. This novel technique is described here; its value and applicability are discussed in the context of fine-needle aspiration biopsies of soft tissue tumors.

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Fine-needle aspiration cytology of sarcoma: Retrospective review of diagnostic utility and specificity

Cited by 110 publications

References 13 publications

Percutaneous CT-guided biopsy of the spine: results of 430 biopsies

Percutaneous CT-guided biopsy of the spine: results of 430 biopsies

Concordance of histopathologic and cytologic grading in musculoskeletal sarcomas

Successful retrieval of fine-needle aspiration biopsy material from previously stained smears for immunocytochemistry: a novel technique applied to three soft tissue tumors

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