Fine Needle Aspiration Cytology of Mixed Medullary-Follicular Thyroid Carcinoma

Fine needle aspiration cytology of medullary carcinoma of the thyroid with a focus on rare variants: a review of 78 cases

“…Immunohistochemistry for thyroglobulin is positive in the follicular areas while calcitonin is positive in the medullary areas, as was demonstrated in the case seen in this study. Cytological descriptions of the follicular variant as well as the mixed follicular and medullary type have been reported before, where the presence of cells having a follicular arrangement has been the main feature 17–19 . Both these cases did show presence of a follicular arrangement on FNAC, but background cells were typical for MCT.…”

“…[6][7][8][9][10][11][12][13][14][15] However, a systematic study evaluating the cytology of medullary carcinoma with emphasis on variants and their distinction from the usual types of medullary carcinoma is not available, being restricted to a few case reports. [16][17][18][19][20][21][22][23][24][25] The present study, based on 78 aspirates, highlights the majority of medullary carcinoma variants and their cytological findings.…”

“…Cytological descriptions of the follicular variant as well as the mixed follicular and medullary type have been reported before, where the presence of cells having a follicular arrangement has been the main feature. [17][18][19] Both these cases did show presence of a follicular arrangement on FNAC, but background cells were typical for MCT. Because a follicular arrangement is seen even in usual MCT on FNAC, in 14.1% of aspirates, specific cytological recognition of both these types is likely to be difficult.…”

“…The standard diagnostic criteria for MCT are well established from a few large series evaluating cytomorphological features 6–15 . However, a systematic study evaluating the cytology of medullary carcinoma with emphasis on variants and their distinction from the usual types of medullary carcinoma is not available, being restricted to a few case reports 16–25 . The present study, based on 78 aspirates, highlights the majority of medullary carcinoma variants and their cytological findings.…”

Detection of medullary thyroid microcarcinoma using ultrasound‐guided fine needle aspiration cytology

“…Mixed medullary‐follicular carcinomas are diagnosed on histology, usually with an FNA diagnosis of MTC 17,18 . None of our seven cases were mixed medullary follicular carcinoma on histology.…”