Fine needle aspiration cytology of head and neck masses: a cytohistopathological correlation study with emphasis on false positives and false negatives

Paker, İrem; Kulaçoğlu, Sezer; Eruyar, Tuğrul; Ergül, Gülüşan

doi:10.5606/kbbihtisas.2013.27048

Cited by 5 publications

(4 citation statements)

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“…FNAC has been known to accurately diagnose lymphoid hyperplasia, granulomatous lymphadenitis, infectious disease, and metastatic tumors and to be suitable for rapidly monitoring the effects of treatment without the need for an excisional biopsy [20]. When accompanied by clinical and radiographic evidence, FNAC is a diagnostic technique that can prevent unnecessary surgery and accurately identify benign and malignant tumors [21]. In this study, fifteen (3.5%) of the samples showed inadequate specimens with few cellular components, five of the fifteen samples diagnosed as inadequate/non-diagnostic by FNAC were histologically diagnosed as metastatic carcinoma.…”

Section: Discussionmentioning

confidence: 99%

Utility and Limitations of Fine-Needle Aspiration Cytology in the Diagnosis of Lymphadenopathy

Lee

Kim

et al. 2023

Diagnostics

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Background: Fine needle aspiration cytology (FNAC) is a valuable tool for evaluating lymphadenopathy. The purpose of this study was to assess the reliability and effectiveness of FNAC in the diagnosis of lymphadenopathy. Methods: Cytological characteristics were evaluated in 432 patients who underwent lymph node FNAC and follow-up biopsy at the Korea Cancer Center Hospital from January 2015 to December 2019. Results: Fifteen (3.5%) of the four hundred and thirty-two patients were diagnosed as inadequate by FNAC, with five (33.3%) of these diagnosed as metastatic carcinoma on histological examination. Of the 432 patients, 155 (35.9%) were diagnosed as benign by FNAC, with seven (4.5%) of these diagnosed histologically as metastatic carcinoma. A review of the FNAC slides, however, showed no evidence of cancer cells, suggesting that the negative results may have been due to FNAC sampling errors. An additional five samples regarded as benign on FNAC were diagnosed as non-Hodgkin lymphoma (NHL) by histological examination. Of the 432 patients, 223 (51.6%) were cytologically diagnosed as malignant, with 20 (9.0%) of these diagnosed as tissue insufficient for diagnosis (TIFD) or benign on histological examination. A review of the FNAC slides of these 20 patients, however, showed that 17 (85.0%) were positive for malignant cells. The sensitivity, specificity, positive predictive value (PPV), negative predictive values (NPV), and accuracy of FNAC were 97.8%, 97.5%, 98.7%, 96.0%, and 97.7%, respectively. Conclusions: Preoperative FNAC was safe, practical, and effective in the early diagnosis of lymphadenopathy. This method, however, had limitations in some diagnoses, suggesting that additional attempts may be required according to the clinical situation.

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Section: Discussionmentioning

confidence: 99%

Utility and Limitations of Fine-Needle Aspiration Cytology in the Diagnosis of Lymphadenopathy

Lee

Kim

et al. 2023

Diagnostics

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“…It is easy to perform and also relatively cheap. FNAC has high sensitivity (94.6%), specificity (97.9%), accuracy (96.7%), and both positive predictive (95.9%) and negative predictive (97.2%) value in the diagnosis of neck masses [17]. FNAC also serves as an excellent preliminary screening procedure.…”

Section: Discussionmentioning

confidence: 99%

Prospective descriptive study of non-thyroidal neck swellings in western indian population

Husain

Rajagopalan²,

Nair³

et al. 2022

ijmmr

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Background. Nonthyroidal neck swellings are common and cause diagnostic challenges. This study highlights various diagnosis associated with non-thyroidal neck swellings and their management challenges. Objective. This pilot study highlights the various diagnosis associated with nonthyroidal neck swellings and their management challenges. The clinical spectrum of two most common aetiology of nonthyroidal neck swelling: tubercular cervical lymphadenopathy and lymphomas, are also compared. Methods. This prospective study was conducted in a tertiary care teaching hospital from 01 Jun 2018 to 31 Dec 2019. The first 100 nonthyroidal neck swellings presented to the surgical outpatient department were included and assessed clinically, radiologically and histopathologically. Comparison was carried out between the first two common diagnosis of tubercular cervical lymphadenitis and lymphoma. Continuous variables were analysed using Student’s t-test and categorical data were analysed using the Chi square test. A statistical p value <0.05 was taken as significant. Results. There were 73 lymph node swellings and 27 non-lymph node swellings in the study. The most common diagnosis was tubercular cervical lymphadenitis (n=38) and lymphoma (n=17). The mean volume of lymph nodes in the lymphoma group (38.72±22.12 cm3) was significantly bigger than in the tuberculosis group (9.44±5.99 cm3) P=0.00001. The mean age (33.81±11.8 years) of tubercular patients was significantly less than the lymphoma (52.38±25.3 years) with P=0.000167. The clinical diagnosis was nearly accurate in 85% of cases. However, in 15 cases clinical diagnosis was changed after fine needle aspiration cytology. Conclusions. Ultrasonography and fine needle aspiration cytology are very useful adjunct in arriving at a definite diagnosis of a lymph node swelling in neck. Tubercular cervical lymphadenopathy and lymphoma were two major diagnosis. Tubercular cervical lymphadenopathy is significantly different from lymphomas in terms of early age of presentation and smaller size at the time of presentation.

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“…[10] When supported by clinical and radiological findings, FNAC is a diagnostic method that can prevent unnecessary surgery and distinguish with high accuracy between benign and malignant lesions. [11] Although FNA is a simple, fast, and inexpensive method to diagnose head and neck masses and is increasingly used in routine practice, histopathological evaluation is still considered to be the gold standard for the final diagnosis. [3,12] There are studies evaluating the efficacy of FNAC in head and neck masses in the literature.…”

Section: Discussionmentioning

confidence: 99%

Fine needle aspiration cytology in the diagnosis of lymph nodes: Correlation with histopathological diagnosis

Altınboğa¹

2019

South Clin Ist Euras

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Lymph node fine-needle aspiration cytology (FNAC) is usually the first step in the evaluation of an enlarged lymph node. It is a rapid, minimally invasive, and less expensive procedure than histopathological examination. The aim of this study was to analyze the diagnostic adequacy of lymph node FNAC compared with histopathological diagnosis. Methods: A total of 171 lymph node FNAC results performed between 2016 and 2017 were reviewed for inclusion in this study. In all, the FNAC results of 41 cases sampled with Tru-Cut (Merit Medical Systems, Inc., South Jordan, UT, USA) and/or excisional biopsy were compared with the histopathological findings. Results: The FNAC diagnosis of 13 benign cases (13/13), 3 reported as atypia of undetermined significance (3/4), 8 that were suspected malignancy (8/9), and 13 malignant cases (13/13) were well correlated with the final histopathological diagnoses. The overall diagnostic sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were found to be 95.4%, 94.1%, 95.4%, 94.1%, and 94.9% respectively. The false negative rate was 2.4% and the false positive rate was 2.4%. Conclusion: FNAC of lymph nodes is a highly sensitive and specific method to diagnose lymph node pathologies. It is a reliable diagnostic tool in the evaluation of an enlarged lymph node.

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Fine needle aspiration cytology of head and neck masses: a cytohistopathological correlation study with emphasis on false positives and false negatives

Cited by 5 publications

References 0 publications

Utility and Limitations of Fine-Needle Aspiration Cytology in the Diagnosis of Lymphadenopathy

Utility and Limitations of Fine-Needle Aspiration Cytology in the Diagnosis of Lymphadenopathy

Prospective descriptive study of non-thyroidal neck swellings in western indian population

Fine needle aspiration cytology in the diagnosis of lymph nodes: Correlation with histopathological diagnosis

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