Fine Needle Aspiration Cytology in Lymphadenopathy of HIV-Positive Cases

Saikia, Uma Nahar; Dey, Pranab; Jindal, Babita; Saikia, Biman

doi:10.1159/000327869

Cited by 38 publications

(46 citation statements)

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“…Similar observations were also contributed by Saikia et al [3] , Vanisri et al [5] Another study done by Ratan K. et al [15] in Imphal mentioned the most common lesion to be non-specific reactive lymphadenitis constituted about 42.1% followed by tuberculous lymphadenitis (38.84%). All the cases of reactive lymphadenitis were negative for AFB.…”

Section: Discussionsupporting

confidence: 81%

“…Parikh U.R. et al [11] , Bates E.M. et al [12] and Saikia U.N. et al [3] reported much higher male predominance in their studies. While other studies like Deshmukh A.T. et al [13] mentioned the ratio to be 1.7:1, Laishram R.S.…”

Section: Discussionmentioning

confidence: 94%

“…[1] Although the epidemic burden of the disease considerably varies from countries and regions, [2] the incidence of human immunodeficiency virus (HIV) infection is seen to be increasing in Asia particularly in the Indian subcontinent. [3] Irrespective of the portal of entry of HIV; lymphoid tissues are the major anatomic sites for establishment and propagation of the infection with HIV. [4] India is found to have the third highest number of estimated people living with HIV/AIDS, after South Africa and Nigeria.…”

Section: Introductionmentioning

confidence: 99%

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Fnac of Hiv Lymphadenopathy in a Tertiary Care Hospital: A Two Year Study

Surase¹,

Deka²,

Solanke³

et al. 2016

jemds

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The incidence of Human Immunodeficiency Virus (HIV) infection is seen to be increasing in Asia, particularly in the Indian subcontinent. Immune system and the central nervous system are the two major targets of this infection. HIV infection is often associated with a number of opportunistic infections and malignancies, presenting with lymphadenopathy which is one of the earliest manifestations of HIV infection. Hence, this study was done to evaluate the diagnostic utility of Fine Needle Aspiration Cytology (FNAC) for HIV positive lymphadenopathy patients and to analyse the different cytological diagnostic patterns of lymph node lesions in HIV/AIDS patients. MATERIALS AND METHODSA total of 70 cases were studied in this prospective study. Fine needle aspiration was done. Both alcohol fixed and air dried smears were prepared. Lymph node aspirates were stained with Haematoxylin and Eosin (H&E), Papanicolaou's stain (PAP), Giemsa and Ziehl and Neelsen (ZN) stain. All these stains were done in all the cases irrespective of the cytological findings. RESULTS AND DISCUSSIONIn the present study, out of 70 HIV positive patients, 40 (57.14%) were males and 30 (42.86%) were females with a male-tofemale ratio of 1.3:1. Maximum affected patients were seen in the age group of 31-40 years. The most common site of HIV lymphadenopathy is the cervical lymph nodes 47 (67.14%), followed by axillary 08 (11.44%), inguinal, submandibular and supraclavicular 04 (5.71%) cases each. The most common presentation was tuberculous lymphadenitis constituted about 42 (60%) cases. CONCLUSIONFNAC is reliable and inexpensive technique for evaluation and identification of opportunistic infections, neoplastic lesions and non-neoplastic lesions. In HIV patients, it helps in segregating cases which requires further evaluation. This is a quick and repeatable procedure which spare patients from lymph node excision and enable immediate treatment of specific infection.

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Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

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Fnac of Hiv Lymphadenopathy in a Tertiary Care Hospital: A Two Year Study

Surase¹,

Deka²,

Solanke³

et al. 2016

jemds

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“…La mayoría de los trabajos sobre adenopatías en estos pacientes se ha llevado a cabo en países donde la tuberculosis es endémica (India, Brasil, Irán, Zambia y Malasia) y donde, además, el número de pacientes con sida es alto y el acceso al tratamiento antirretroviral altamente efectivo es bajo, al igual que en nuestro país (3,5,6,(13)(14)(15)(16)(17)(18)(19). A diferencia de estos estudios, en los cuales la mayoría de los ganglios estudiados se evaluaron mediante una biopsia por aspiración con aguja fina, todos los pacientes en este estudio se sometieron a biopsia por escisión de ganglio linfático.…”

Section: Discussionunclassified

“…Dadas las condiciones epidemiológicas mencionadas, era predecible que la infección más común fuera la tuberculosis (casi la mitad), lo cual coincide con los datos publicados en otras series, donde la frecuencia ha oscilado entre el 26 y el 67 % (3,6,(13)(14)(15)(16)(17)(18)(19). En un estudio en Sudáfrica, Maartens, et al, encontraron una frecuencia mucho mayor de tuberculosis (92 %) (5), diferencia que probablemente se deba a la mayor incidencia de esta enfermedad en ese país (860 casos por 100.000 habitantes, en comparación con 26 por cada 100.000 en Colombia) (20) y porque, además, en dicho estudio la población evaluada incluyó solo a pacientes con sospecha de tuberculosis y con baciloscopia de esputo negativa.…”

Section: Discussionunclassified

Pathological findings in patients with HIV infection and lymphadenopathies

et al. 2017

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: recolección de la información Todos los autores participaron en la generación del proyecto, el desarrollo del protocolo, el análisis de la información y la escritura del manuscrito. Introducción. Las adenopatías son un hallazgo frecuente en pacientes con infección por el virus de la inmunodeficiencia humana (HIV). El diagnóstico diferencial incluye infecciones, neoplasias malignas o cambios reactivos. No existen datos sobre su etiología en Suramérica. Objetivo. Describir la etiología de la histopatología ganglionar en pacientes con HIV del Hospital La María de Medellín. Materiales y métodos. Se evaluaron de manera retrospectiva historias clínicas de pacientes con HIV y linfadenopatías, a quienes se les había hecho biopsia por escisión de ganglio linfático entre junio de 2009 y octubre de 2011. Se registraron los datos de los resultados de las biopsias en cuanto al estado de inmunosupresión, el uso de tratamiento antirretroviral y el diagnóstico final de los pacientes. Resultados. Se evaluaron 120 historias clínicas, con diagnósticos distribuidos así: 58 % de origen infeccioso, 32,5 % con cambios reactivos, 6,6 % de origen neoplásico y 2,5 % normales. El diagnóstico más frecuente fue la tuberculosis (48,3 %). En 14,1 % de los pacientes, la biopsia de ganglio linfático sirvió para detectar otra infección oportunista además de las encontradas en otros órganos. Conclusión. La biopsia de ganglio linfático en pacientes con HIV es una herramienta útil que permite el diagnóstico de enfermedades infecciosas y neoplásicas graves, y que debería hacerse de rutina en todos los pacientes con adenopatías. Hallazgos patológicos en adenopatías de pacientes con infección por HIV

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Fine‐needle aspiration cytology in lymphadenopathy of HIV‐positive patients

Nayak

Mani

Kavatkar

et al. 2003

Diagnostic Cytopathology

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Fine-needle aspiration cytology (FNAC) of 32 HIV-positive cases presenting with lymphadenopathy was performed to evaluate its role in this group of patients. For each case air-dried smears were stained with Leishman, hematoxylin and eosin, and Zeihl-Neelsen stains for acid fast bacilli (AFB). The results were tuberculous (TB) lymphadenopathy (15), reactive lymphadenopathy (10), acute lymphadenitis/abscess (5), and suspected malignancy (2). In seven cases of TB lymphadenitis findings were suggestive of TB since no AFB was demonstrable on the cytology smears. In TB lymphadenitis, two additional patterns besides necrotising granulomatous (4) and granulomatous (2) were observed. These were necrotising (6) and necrotising suppurative (3) patterns. FNAC is a simple, inexpensive, rapid investigative procedure which can reduce surgical excisions and provide definite guidelines about further management.

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Fine Needle Aspiration Cytology in Lymphadenopathy of HIV-Positive Cases

Cited by 38 publications

References 10 publications

Fnac of Hiv Lymphadenopathy in a Tertiary Care Hospital: A Two Year Study

Fnac of Hiv Lymphadenopathy in a Tertiary Care Hospital: A Two Year Study

Pathological findings in patients with HIV infection and lymphadenopathies

Fine‐needle aspiration cytology in lymphadenopathy of HIV‐positive patients

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