Fine‐needle aspiration cytology in lymphadenopathy of HIV‐positive patients

Abstract

Fine-needle aspiration cytology (FNAC) of 32 HIV-positive cases presenting with lymphadenopathy was performed to evaluate its role in this group of patients. For each case air-dried smears were stained with Leishman, hematoxylin and eosin, and Zeihl-Neelsen stains for acid fast bacilli (AFB). The results were tuberculous (TB) lymphadenopathy (15), reactive lymphadenopathy (10), acute lymphadenitis/abscess (5), and suspected malignancy (2). In seven cases of TB lymphadenitis findings were suggestive of TB since no AFB was demonstrable on the cytology smears. In TB lymphadenitis, two additional patterns besides necrotising granulomatous (4) and granulomatous (2) were observed. These were necrotising (6) and necrotising suppurative (3) patterns. FNAC is a simple, inexpensive, rapid investigative procedure which can reduce surgical excisions and provide definite guidelines about further management.

Role of fine-needle aspiration cytology in human immunodeficiency virus-associated lymphadenopathy: a cross-sectional study from northern India

“…We found this pattern in 5.4% (2 out of 37 cases with tubercular lymphadenitis) of TB cases, a finding similar to that in other previous studies where it ranged from 4.3% Abbreviations: FNAC = fine-needle aspiration cytology; TB = tuberculosis * Western data † Indian data to 28.5% (Table 4). 6,9,11,12,16,23 The NGL pattern, with both caseation and epithelioid granulomas, is the most typical pattern of tubercular lymphadenitis. It was present in 18.9% (7 out 37 cases of tubercular lymphadenitis) of our cases; other studies have reported it in the range of 26.6% to 74% (Table 4).…”

Pathological findings in patients with HIV infection and lymphadenopathies

“…La mayoría de los trabajos sobre adenopatías en estos pacientes se ha llevado a cabo en países donde la tuberculosis es endémica (India, Brasil, Irán, Zambia y Malasia) y donde, además, el número de pacientes con sida es alto y el acceso al tratamiento antirretroviral altamente efectivo es bajo, al igual que en nuestro país (3,5,6,(13)(14)(15)(16)(17)(18)(19). A diferencia de estos estudios, en los cuales la mayoría de los ganglios estudiados se evaluaron mediante una biopsia por aspiración con aguja fina, todos los pacientes en este estudio se sometieron a biopsia por escisión de ganglio linfático.…”

“…Dadas las condiciones epidemiológicas mencionadas, era predecible que la infección más común fuera la tuberculosis (casi la mitad), lo cual coincide con los datos publicados en otras series, donde la frecuencia ha oscilado entre el 26 y el 67 % (3,6,(13)(14)(15)(16)(17)(18)(19). En un estudio en Sudáfrica, Maartens, et al, encontraron una frecuencia mucho mayor de tuberculosis (92 %) (5), diferencia que probablemente se deba a la mayor incidencia de esta enfermedad en ese país (860 casos por 100.000 habitantes, en comparación con 26 por cada 100.000 en Colombia) (20) y porque, además, en dicho estudio la población evaluada incluyó solo a pacientes con sospecha de tuberculosis y con baciloscopia de esputo negativa.…”

Efficacy of fine needle aspiration cytology in the diagnosis of lymphadenopathies

“…2 FNAC is a simple, inexpensive, rapid investigative procedure with minimal trauma and low complication rate. 3 The material obtained from FNA can be used for diverse group of special techniques like cyto-chemistry, bacteriological culture, immune cyto-chemistry, ultra-structural studies and molecular hybridization. 4 For determining the diagnostic accuracy of FNAC, it is a usual practice to correlate cyto-diagnosis with subsequent histopathological examination of excised biopsy specimens.…”