Fine Needle Aspiration Cytology Diagnosis of Renal Medullary Carcinoma

Qi, Jiafan; Shen, Peter U.F.; Rezuke, William N.; Currier, Allen A.; Westfall, Paul K.; Mandavilli, Srinivas

doi:10.1159/000328296

Cited by 18 publications

(17 citation statements)

References 6 publications

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“…The renal pelvic washings in our case showed similar findings as well as some tumor cells with finely vacuolated cytoplasm. Qi et al 11 reported a case in which FNA of a renal tumor revealed findings similar to ours. Pleomorphic tumor cells were arranged predominantly in groups, and some of the single cells had an eccentrically placed nucleus.…”

Section: Discussionsupporting

confidence: 86%

“…2 There are only rare case reports describing the cytologic findings of renal medullary carcinoma. 11,12 Larson et al 12 reported on a black woman age 18 years who presented with macroscopic hematuria. Malignant cells that were identified in her urine and cervical smear specimens initially were interpreted as transitional cell carcinoma.…”

Section: Discussionmentioning

confidence: 99%

“…1 Several reports describe the histologic findings [1][2][3][4][5][6][7][8][9][10] for this unusual tumor, but case reports that focus on the cytologic features are rare. 11,12 We describe the cytologic findings in three cases of renal medullary carcinoma, all of which occurred in young black men with sickle cell trait and the clinical findings are summarized in Table 1.…”

mentioning

confidence: 99%

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Cytologic features of renal medullary carcinoma

Assad

Resetkova

Oliveira

et al. 2004

Cancer

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Cytologic features of renal medullary carcinoma

Assad

Resetkova

Oliveira

et al. 2004

Cancer

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“…Rare publications have described cytologic features of RMC. [3456789] Cytologically, the tumor cells have been described to be present in sheets, loosely cohesive clusters, or singly. They have high-grade nuclear features with hyperchromatic, enlarged, pleomorphic nuclei, and prominent nucleoli in most cases.…”

Section: Brief Discussion With Follow-upmentioning

confidence: 99%

Lung tumor in a young African American patient with sickle trait: Pieces of a puzzle

et al. 2018

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“…Klasik triad olan yan ağrısı, makroskopik hematüri ve palpabl abdominal kitle genellikle hastalığın ilerlemiş dönemlerinde görülmektedir (5,6,7,8). RHK olguların %20'sinde sistemik veya paraneoplastik sendromlara ait semptomlar izlenirken mikroskobik ve/veya makroskobik hematüri %60 olguda izlenmektedir (9,10). Paraneoplastik sendromlar, tümörden salgılanan maddelere bağlı gelişen veya vücudun tümöre yanıtı olarak ortaya çıkan endokrin veya endokrin olmayan semptomlar topluluğudur (11) (Tablo 1).…”

Section: Introductionunclassified

Renal Hücreli Kanserde Paraneoplastik Sendromlar

İzol¹,

Kaplan²

2014

uob

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Genitoüriner kanserler arasında renal hücreli karsinom, hastaların yaklaşık üçte birinde paraneoplastik sendroma ait semptom ve bulguların görülebilmesiyle kendini gösteren bir patolojidir. Renal hücreli karsinom ile ilgili paraneoplastik sendromlar konstitüsyonel semptomları (örneğin; ateş, kaşeksi ve kilo kaybı) ve bunun yanı sıra spesifik metabolik ve biyokimyasal anormallikleri (örneğin; hiperkalsemi, nonmetastatik hepatik disfonksiyon, amiloidoz vb.) içermektedir. Paraneoplastik sendrom varlığı ne metastatik hastalık işareti ne de kötü prognoz göstergesidir. Renal hücreli karsinom ile ilgili paraneoplastik sendromların patofizyolojisi ve biyolojisinin anlaşılmasıyla birlikte, konstitüsyonel semptomlar veya metabolik anormallikler primer veya tekrarlayan hastalığın ilk belirtisi olabilir. Bu hastalarda, paraneoplastik sendromların doğru tanısı ve yönetimi hastaların palyatif tedavisinde önemli olabilir. RHK ile ilgili kaşeksi, ateş, karaciğer fonksiyon bozukluğu, anemi ve amiloidoz gibi paraneoplastik belirtilerin patofizyolojisi henüz tam olarak aydınlatılamamıştır. Hiperkalsemi dışındaki paraneoplastik sendromlarda geleneksel medikal tedaviler nadiren faydalıdır. Erken tanı ve etkin tedavi bu hastaların yaşam kalitesini ve prognozunu değiştirebilir. Bu derlemede, renal hücreli karsinom ile ilgili birçok paraneoplastik sendromun ortaya çıkış mekanizmalarıyla birlikte, bunların klinik yansımalarını ve bu önemli bozukluklar için mevcut tedavi seçeneklerini tartışacağız. (Üroonkoloji Bülteni 2014;13:130-134) Anah tar Ke li me ler: Paraneoplastik sendrom, renal hücreli kanser, hiperkalsemi Renal cell carcinoma which is among genitourinary cancers is a pathology presenting with signs and symptoms of paraneoplastic syndrome in almost one third of the affected patients. The paraneoplastic syndromes associated with renal cell carcinoma include constitutional symptoms (ie, fever, cachexia, and weight loss), as well as specific metabolic and biochemical abnormalities (ie, hypercalcemia, nonmetastatic hepatic dysfunction, amyloidosis, etc). The presence of a paraneoplastic syndrome in a patient with renal cell carcinoma is neither a marker of metastatic disease nor necessarily indicative of a poor prognosis. The importance of understanding the pathophysiology and biology behind the many paraneoplastic syndromes associated with renal cell carcinoma lies in the fact that the presence of these protean symptoms may be the initial presentation of either primary or recurrent disease. In these patients, the accurate diagnosis and management of paraneoplastic syndromes may be important in palliative management. Pathophysiology of paraneoplastic symptoms of RCC such as cachexia, fever, hepatic dysfunction, anemia, and amyloidosis, remains incomplete. Except for hypercalcemia, conventional medical therapies are seldom helpful in the treatment of paraneoplastic symptoms. An early diagnosis and effective treatment might improve quality of life and alter prognosis of these patients. In this review, we will describe the proposed...

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Fine Needle Aspiration Cytology Diagnosis of Renal Medullary Carcinoma

Cited by 18 publications

References 6 publications

Cytologic features of renal medullary carcinoma

Cytologic features of renal medullary carcinoma

Lung tumor in a young African American patient with sickle trait: Pieces of a puzzle

Renal Hücreli Kanserde Paraneoplastik Sendromlar

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