Cytologic features of renal medullary carcinoma

Assad, Lina; Resetkova, Erika; Oliveira, Victor L.; Sun, Wei; Stewart, John; Katz, Ruth L.; Caraway, Nancy P.

doi:10.1002/cncr.20764

Cited by 32 publications

(25 citation statements)

References 22 publications

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“…[1][2][3][4][5][6][7]16,17 Prominent rhabdoid features have also been identified and are characteristic of epithelioid sarcoma and atypical/teratoid tumors of the central nervous system. The rare renal medullary carcinoma seems restricted to patients with sickle-cell disease or trait, [1][2][3][4][5][6][7] and despite varied histologic growth patterns also manifests variably prominent rhabdoid cytology. The possibility of a genetic connection between a rhabdoid cytologic phenotype and the aggressive biologic behavior of tumors, which exhibit this feature has not yet been elucidated.…”

Section: Discussionmentioning

confidence: 99%

“…This tumor predominantly arises in the renal medulla and may exhibit a variety of growth patterns including reticular, solid, tubular, trabecular, cribriform, sarcomatoid and micropapillary. [1][2][3][4][5][6][7] The tumor cells usually have large vesicular nuclei and prominent nucleoli with densely opaque eosinophilic cytoplasm. Eccentric nuclear displacement in some cases creates a rhabdoid appearance.…”

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confidence: 99%

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Renal medullary carcinoma: rhabdoid features and the absence of INI1 expression as markers of aggressive behavior

et al. 2008

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Renal medullary carcinoma is a rare, well-recognized highly aggressive tumor of varied histopathology, which occurs in young patients with sickle cell trait or disease. Rhabdoid elements, occasionally seen in high-grade renal tumors including renal medullary carcinoma, possibly represent a pathologic marker of aggressive behavior. INI1 (hSNF5/SMARCB1/BAF47) is a highly conserved factor in the ATP-dependent chromatinmodifying complex. Loss of this factor in mice results in aggressive rhabdoid tumors or lymphomas. In humans, the loss of INI1 expression has been reported in pediatric renal rhabdoid tumors, central nervous system atypical teratoid/rhabdoid tumors and epithelioid sarcomas, a possible primary soft tissue rhabdoid tumor. This study compares five renal medullary carcinomas with 10 high-grade renal cell carcinomas (five with rhabdoid features), two urothelial carcinomas and two pediatric renal rhabdoid tumors. All five renal medullary carcinomas, irrespective of histopathology, showed complete loss of INI1 expression similar to that seen in pediatric renal rhabdoid tumors. In contrast, all renal cell carcinomas or urothelial carcinomas, including those with histological rhabdoid features, expressed INI1. Clinically, all five of the patients with renal medullary carcinoma and the two patients with rhabdoid tumors presented with extra-renal metastases at the time of diagnosis. This study demonstrates that renal medullary carcinoma and renal rhabdoid tumor share a common molecular/genetic alteration, which is closely linked to their aggressive biological behavior. However, the absence of INI1 expression is not necessarily predictive of rhabdoid histopathology but remains associated with aggressive behavior in renal medullary carcinoma.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Renal medullary carcinoma: rhabdoid features and the absence of INI1 expression as markers of aggressive behavior

et al. 2008

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“…Rare publications have described cytologic features of RMC. [3456789] Cytologically, the tumor cells have been described to be present in sheets, loosely cohesive clusters, or singly. They have high-grade nuclear features with hyperchromatic, enlarged, pleomorphic nuclei, and prominent nucleoli in most cases.…”

Section: Brief Discussion With Follow-upmentioning

confidence: 99%

“…Inflammation, stromal fragments, and sickle red blood cells may be present in the background. [345678919] The tumor cells are positive for mucin, typically positive for CK7, and vimentin (focal) and are negative for HMWCK, with only a few cases reported as positive for ulex europaeus agglutinin 1 lectin (UEA-1).…”

Section: Brief Review Of the Topicmentioning

confidence: 99%

Lung tumor in a young African American patient with sickle trait: Pieces of a puzzle

et al. 2018

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“…Lesions are tan to gray, fi rm, and lobulated, with areas of necrosis and hemorrhage common ( Fig. 10.21 ) [ 101 ]. Tumors have an average diameter of 7.4 cm (range: 1.9-18 cm) and are not predominantly cystic.…”

Section: Renal Medullary Carcinomamentioning

confidence: 98%

Malignant Renal Tumors

Shehata

Naguib

Lin

et al. 2014

Pediatric Malignancies: Pathology and Imaging

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Renal tumors account for approximately 6-7 % of all pediatric cancers, with Wilms' tumor being the most common malignancy [ 1 , 2 ]. Current classifi cation and staging criteria for renal tumors, aided by advances in molecular and cytogenetic abnormalities, have allowed accurate diagnostic, staging, and therapeutic protocols [ 2 ], elucidated new categories of renal neoplasms, and created more inclusive classifi cation (Table 10.1 ) [ 2 , 3 ]. Overview of Imaging FeaturesThe imaging evaluation of a suspected pediatric renal mass should always begin with ultrasound. Sonography is readily available, can be performed without sedation and intravenous contrast, and does not expose the child to ionizing radiation. If a renal mass is identifi ed on ultrasound, further evaluation of the renal vessels and inferior vena cava (IVC) with both gray scale and color Doppler images are required to detect vascular extension, present in up to 10 % of cases [ 4 ]. Further evaluation with contrast enhanced computed tomography (CT) or magnetic resonance imaging (MRI) is also required for local staging of the mass prior to any intervention, as per the guidelines of the Children's Oncology Group (COG). Either modality can be used, depending on institutional availability and expertise [ 5 ].In keeping with the As Low As Reasonably Achievable (ALARA) principle regarding ionizing radiation exposure, pre-contrast and multiphase contrast enhanced CT images are not required for diagnosis or staging of pediatric renal tumors [ 6 ]. A single-phase study in the portal venous phase (approximately 50 s after contrast injection) suffi ciently stages a renal tumor and delineates relevant anatomy. Multiplanar CT reconstructions or multiplanar scanning with MRI can confi rm the renal origin of the mass and assess its relationship to vital structures such as the renal vessels. If a partial nephrectomy is being considered, multiphase images are helpful to determine the relationship of the mass to the renal vessels and collecting system. A CT of the chest is required in all malignant renal tumors to evaluate for potential lung metastasis. Wilm's Tumor Defi nitionWilms' tumor ( syn: nephroblastoma), a malignant neoplasm originating from nephrogenic blastemal cells, is the second most common malignant, solid extracranial tumor in children [ 1 , 7 , 8 ]. It is a traditional blastematous tumor, exhibiting various stages of embryonic development and multiple lines of differentiation. Clinical Features and EpidemiologyIn children ranging from 0 to 15 years of age, Wilms' tumor occurs in seven to ten cases per million annually (1 in 10,000 children) and accounts for approximately 95 % of renal tumors, and comprises 6-7 % of all pediatric tumors [ 7 , 9 , 10 ]. It is the fi fth most common pediatric tumor and the second most common intraabdominal tumor in children [ 11 ].

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Cytologic features of renal medullary carcinoma

Cited by 32 publications

References 22 publications

Renal medullary carcinoma: rhabdoid features and the absence of INI1 expression as markers of aggressive behavior

Renal medullary carcinoma: rhabdoid features and the absence of INI1 expression as markers of aggressive behavior

Lung tumor in a young African American patient with sickle trait: Pieces of a puzzle

Malignant Renal Tumors

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