Fine-needle aspiration cytologic features of pseudovascular adenoid squamous-cell carcinoma of the lung

Smith, Allan; Raab, Stephen S.; Landreneau, Rodney J.; Silverman, Jan F.

doi:10.1002/(sici)1097-0339(199910)21:4<265::aid-dc7>3.0.co;2-c

Cited by 17 publications

(20 citation statements)

References 34 publications

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“…In humans, PASCC has been reported in the lung, 13 breast, 1,2 female reproductive tract, 6 skin, 2,10 and oral cavity. 9,15 In contrast to the present case, the human reports of oral involvement do not mention tumor invasion into the underlying bone.…”

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confidence: 99%

“…5 The human entity is characterized by anastomosing cords of epithelioid cells, with multiple vascular clefts formed within the neoplastic nodules. 1,2,6,10,13,15 The vascular clefts are believed to be caused by acantholysis of the neoplastic cells that occurs at the center of the neoplastic cords, with subsequent infiltration of these clefts by erythrocytes. Decreased expression of intercellular adhesion molecules, such as E-cadherin and syndecan-1, results in decreased adhesion of epithelial cells, which eventually leads to acantholysis.…”

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confidence: 99%

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Pseudoangiomatous Squamous Cell Carcinoma in the Oral Cavity of a Dog

et al. 2010

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Abstract. An 8-year-old, spayed, female Labrador Retriever mixed-breed dog was presented to the Cornell University Hospital for Animals with an invasive oral mass involving the upper left fourth premolar and first molar teeth. Initial biopsy results suggested a poorly differentiated squamous cell carcinoma, whereas further histologic examination of the surgically removed mass revealed a hemangiosarcoma-like mass composed of numerous vascular clefts and variable numbers of keratinizing epithelial cells. Histologic and immunohistochemical characteristics were compatible with pseudoangiomatous squamous cell carcinoma, a wellrecognized human variant of acanthomatous squamous cell carcinoma. Because of histomorphologic similarities with canine gingival hemangiosarcoma, diagnosticians should be aware of the present tumor variant as a differential diagnosis for vascular-like growths in the oral cavity of dogs.

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confidence: 99%

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confidence: 99%

Pseudoangiomatous Squamous Cell Carcinoma in the Oral Cavity of a Dog

et al. 2010

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“…7,8 Life expectancy postdiagnosis ranged from 5 to 34 months in one publication 7 but, at ≤ 3 months, was considerably shorter in the two new cases reported here.…”

Section: Discussionmentioning

confidence: 64%

“…14,16,17,19,20 Since the first published case of pulmonary PSCC in 1992, 4 only five additional cases of PSCC of the lung have been reported. 5,7,8 In 2004, the World Health Organization classified these rare squamous cell carcinomas with an angiosarcomatoid character as pleomorphic carcinoma, defined as a type of sarcomatoid carcinoma. 28 Here, two additional cases of pulmonary PSCC are reported: clinical data for all eight published cases are summarized in Table 1 comprising seven males and one female, with ages ranging from 47 to 79 years (mean age 62 years).…”

Section: Discussionmentioning

confidence: 99%

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Pseudoangiosarcomatous Squamous Cell Carcinoma of the Lung

et al. 2011

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Pulmonary pseudoangiosarcomatous squamous cell carcinoma (PSCC) is a rare aggressive variant of squamous cell carcinoma. Histopathologically, PSCC is characterized by interanastomosing cords and channels, lined by atypical cells, with spaces containing erythrocytes or floating tumour cells. PSCC mimics angiosarcoma, so careful attention should be paid to immunohistochemical differences. Two PSCC cases are described here: in a 79-year-old male, bronchoscopy revealed mucosal swelling and hypertrophy and an adrenal mass was found 1 month later; in a 76-year-old male, computed tomography revealed rib destruction due to a non-calcified softtissue tumour and, although the tumour resembled an angiosarcoma, endothelial markers were negative and cytokeratin and p63 markers were positive. Immunohisto chemical analyses may be helpful in establishing an accurate diagnosis. PSCC had a progressive course in both patients, who died ≤ 3 months postdiagnosis.

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Cytologic findings of malignant vascular neoplasms: A study of twenty‐four cases

Minimo

Zakowski

Lin

2002

Diagnostic Cytopathology

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Cytologic characterization of malignant vascular neoplasms (MVN) is difficult due to the wide range of differential diagnoses and sampling errors. The objective of this study was to identify criteria helpful in the cytologic diagnosis of MVN. The clinical presentation and cytomorphologic features of 22 angiosarcomas and two hemangioendotheliomas were analyzed. The criteria evaluated included cellularity, cellular arrangement, cell shape and size, pleomorphism, cytoplasmic borders, nuclear shape and number, chromatin pattern, nucleoli, background, and presence of angioformative structures. A previous history of MVN was noted in 18 of 24 patients. Specimens with epithelioid morphology were more cellular and pleomorphic and contained multinucleated cells. Specimens with spindle morphology were usually less cellular and less pleomorphic. Angioformative structures were identified in 11 of 24 cases. Awareness of features suggestive of MVN is necessary to raise the possibility of vascular origin, which can be confirmed with appropriate immunocytochemical studies.

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Fine-needle aspiration cytologic features of pseudovascular adenoid squamous-cell carcinoma of the lung

Cited by 17 publications

References 34 publications

Pseudoangiomatous Squamous Cell Carcinoma in the Oral Cavity of a Dog

Pseudoangiomatous Squamous Cell Carcinoma in the Oral Cavity of a Dog

Pseudoangiosarcomatous Squamous Cell Carcinoma of the Lung

Cytologic findings of malignant vascular neoplasms: A study of twenty‐four cases

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