Fine Needle Aspiration Biopsy of the Salivary Glands

Cajulis, Ricardo S.; Gokaslan, Sefik T.; Yu, Gordon H.; Frias‐Hidvegi, Denise

doi:10.1159/000332852

Cited by 119 publications

(27 citation statements)

References 4 publications

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“…The adequacy of materials obtained by FNAC in the present study was as high as 100% which is quite comparable to the various studies performed in the past [7][8][9][10][11][12][13] smears showed moderate to hyper cellularity in 92 % cases except for four cases which were cystic lesions. 6,8 A repeat FNAC must be considered from these cystic lesions once adequately aspirated in the first instance provided sialolipohemangioma or any such vascular lesions has been excluded.…”

Section: Kakoty S Et Al Int Surg J 2017 Jul;4(7):2148-2152supporting

confidence: 89%

“…These findings were in coherence with various studies. 7,14 The simple nature of the procedure with high diagnostic yield with minor complications such as focal bleeding in few cases establishes its role in primary diagnosis of salivary gland lesions. The danger of neoplastic cells seedling by FNAC has been refuted by many studies with long follow up.…”

Section: Kakoty S Et Al Int Surg J 2017 Jul;4(7):2148-2152mentioning

confidence: 99%

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FNAC and histopathological correlation of salivary gland lesions: an observational study

Sawhney¹,

Baruah

Babu

2017

Int Surg J

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Background: Fine needle aspiration cytology (FNAC) is a sensitive and specific and yet an economically effective technique for diagnosis of salivary gland lesions. FNAC of salivary glands has achieved a pivotal role in the diagnosis and management of salivary gland lesions since its induction by Stewart et al in 1933. However, it has always been under scrutiny when compared to histopathology. Histopathology of salivary gland lesions is still the final method to establish diagnosis and predicting prognosis in these lesions.1Methods: A prospective observational study of 50 patients with salivary gland lesions was done at Gauhati Medical College and hospital from June 2011 to May 2012. 39 patients underwent histopathological confirmation. Cases with histopathological correlation were included in calculating diagnostic accuracy. The cytological findings were correlated with that of the histopathological diagnosis to obtain the accuracy of the cytological diagnosis. The parameters of diagnostic validity of the cytological technique in terms of sensitivity, specificity and predictive value were evaluated.Results: Study population included patients of age group ranging from 13-70 years with median age group being 31-40 years (30%). 54% of the affected patients were male with the parotid being the most commonly involved gland (62%). Neoplastic lesions constituted the major bulk of the lesions (39 cases, 78%) with benign tumours constituting 54%. The most commonly involved benign neoplastic lesion was pleomorphic adenoma (22cases, 44%). Among the non-neoplastic lesions (22%), the acute sialadenitis was frequently noted. Histopathological correlations were available in 39 cases with 11 cases being the malignant lesions. The acute sialadenitis lesions did not undergo histological examination. 28 cases of non-malignant lesions underwent the histological confirmation. In the present study, the specificity and the sensitivity were found to be 96.42% and 90.91% respectively. The predictive value of salivary gland cytology was 90.91% and diagnostic accuracy was 94.87%.Conclusions: Fine Needle Aspiration Cytology is thus a safe, reliable, quick, convenient and accurate method of diagnosis and should be considered as one of the first line of investigations in the evaluation of salivary gland lesions.

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Section: Kakoty S Et Al Int Surg J 2017 Jul;4(7):2148-2152supporting

confidence: 89%

Section: Kakoty S Et Al Int Surg J 2017 Jul;4(7):2148-2152mentioning

confidence: 99%

FNAC and histopathological correlation of salivary gland lesions: an observational study

Sawhney¹,

Baruah

Babu

2017

Int Surg J

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“…When the classic features of acinic cell carcinoma are present, its diagnosis may not be difficult. However, problems arise when overlapping features are present [7]. The nuclear features of normal (non-neoplastic) acinar cells are quite similar to those observed in acinic cell carcinoma, the only subtle differences is the smaller size of the non-neoplastic acinar cell nuclei as compared with neoplastic acinar one and the basally oriented nuclei in normal cells, whereas in acinic cell carcinoma they are often centrally located.…”

Section: Results and Observationsmentioning

confidence: 90%

“…Cytological detail should be carefully examined i.e. scanty cytoplasm, high nucleus to cytoplasm ratio, naked nuclei, nuclear moulding and nuclear hyperchromasia to avoid errors in the cytological diagnosis of adenoid cystic carcinoma [7].…”

Section: Results and Observationsmentioning

confidence: 99%

Fine Needle Aspiration Cytology of Salivary Gland Lesions and Its Diagnostic Pitfalls – A Tertiary Care Centre Experience From North East India

Roy¹,

Deka²,

Dutta³

2013

jemds

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-INTRODUCTION:Fine needle aspiration cytology (FNAC) of salivary gland lesions has become very popular as a pre-operative diagnostic tool. However, in some instances the final histology of these lesions differs from the FNAC result. OBJECTIVE: To determine the diagnostic accuracy of FNAC in salivary gland lesions and identify the salivary gland FNA cases having discordant histological diagnosis so that most common diagnostic pitfalls can be avoided. MATERIAL AND METHODS: Sixty four salivary gland FNAC cases from January 2009 to December 2010 were retrospectively reviewed to identify the cytological characteristics that may have contributed to this discrepancy. Only 44 cases could be correlated histopathologically. RESULTS: Of the 64 cases analysed cytologically, 4 smears turned out to be unsatisfactory for evaluation, hence only rest 60 smears were evaluated. Out of the 32 cases which were given as cytologically benign, 28 were confirmed as benign on histology, while 04 cases turned out as malignant on histology. Of the 12 cases which were cytologically malignant, 2 turned out to be benign on histology. Taking histology as the "gold standard", the following data were obtained: specificity 92.8%, sensitivity 69.8%, diagnostic accuracy 84.5%, positive predictive value 83% and negative predictive value 83%. CONCLUSION: Despite inadequate samples obtained in some cases, FNAC should be done in the preoperative diagnosis of salivary gland lesions as it offers high diagnostic accuracy and specificity and an acceptable sensitivity.

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“…Cellular aspirate cannot be used for grading, staging or immu nofluorescence and cannot assess the interaction with surrounding tissue. Reactive hyperplasia with atypia in lymph nodes adjacent to the salivary gland is often indistinguishable from lymphoma or squamous cell car cinoma metastases [11] . With Warthin's tumour, cytological misinterpretation may occur due to a lack of characteristic features and overabundance of squamous metaplasia/ atypia, mucoid/mucinous background, spindleshaped cells and cystic/inflammatory debris [16] .…”

Section: Fnacmentioning

confidence: 99%

Biopsy of parotid masses: Review of current techniques

Haldar¹,

Sinnott²,

Tekeli³

et al. 2016

WJR

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Definitive diagnosis of parotid gland masses is required optimal management planning and for prognosis. There is controversy over whether fine needle aspiration cytology (FNAC) or ultrasound guided core biopsy (USCB) should be the standard for obtaining a biopsy. The aim of this review is to assess the current evidence available to assess the benefits of each technique and also to assess the use of intra-operative frozen section (IOFS). Literature searches were performed using pubmed and google scholar. The literature has been reviewed and the evidence is presented. FNAC is an accepted and widely used technique. It has been shown to have variable diagnostic capabilities depending on centres and experience of staff. USCB has a highly consistent diagnostic accuracy and can help with tumour grading and staging. However, the technique is more invasive and there is a question regarding potential for seeding. Furthermore, USCB is less likely to be offered as part of a one-stop clinic. IOFS has no role as a first line diagnostic technique but may be reserved as an adjunct or for lesions not amenable to percutaneous biopsy. On balance, USCB seems to be the method of choice. The current evidence suggests it has superior diagnostic potential and is safe. With time, USCB is likely to supplant FNAC as the biopsy technique of choice, replicating that which has occurred already in other areas of medicine such a breast practice.

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Fine Needle Aspiration Biopsy of the Salivary Glands

Cited by 119 publications

References 4 publications

FNAC and histopathological correlation of salivary gland lesions: an observational study

FNAC and histopathological correlation of salivary gland lesions: an observational study

Fine Needle Aspiration Cytology of Salivary Gland Lesions and Its Diagnostic Pitfalls – A Tertiary Care Centre Experience From North East India

Biopsy of parotid masses: Review of current techniques

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