Background:Helicobacter pylori is one of the most important causes of the varied spectrum of gastroduodenal diseases. It is important to have a rapid diagnostic method to detect the organism so as to initiate the treatment early and check its progression to malignancy.Aims:To evaluate the diagnostic accuracy of rapid urease biopsy test in detecting H. pylori infection and implementation of “test and treat” policy.Materials and Methods:All patients of chronic dyspepsia not responding to conventional treatment were subjected to endoscopy, and mucosal biopsy samples were collected. A rapid urease test (RUT) and histopathology was performed on these samples and taking histopathology as gold standard for H. pylori demonstration, the diagnostic accuracy of RUT was evaluated.Results:The specificity, sensitivity, positive predictive value, negative predictive value, and diagnostic accuracy of RUT were 97.22%, 94.04%, 98.75%, 87.5%, and 95%, respectively.Conclusion:Use of a rapid diagnostic test viz., rapid urease biopsy test to confirm H. pylori infection is recommended for early diagnosis and treatment of H. pylori associated gastroduodenal diseases.
Leiomyosarcomas of vascular origin are rare. They originate from the smooth muscles of tunica media of major blood vessels. The majority of such tumours arising in the extremities affect the femoral vascular bundle. There is limited knowledge and experience of the clinical presentation, pathological reports and results of treatment of this type of tumour. A case of primary leiomyosarcoma of femoral vein is being reported from a subtropical region of India that developed over the right thigh of a 35-year-old male farmer and was clinically diagnosed as benign soft tissue tumour. The diagnosis was confirmed by histopathology and immunohistochemistry.
-INTRODUCTION:Fine needle aspiration cytology (FNAC) of salivary gland lesions has become very popular as a pre-operative diagnostic tool. However, in some instances the final histology of these lesions differs from the FNAC result. OBJECTIVE: To determine the diagnostic accuracy of FNAC in salivary gland lesions and identify the salivary gland FNA cases having discordant histological diagnosis so that most common diagnostic pitfalls can be avoided. MATERIAL AND METHODS: Sixty four salivary gland FNAC cases from January 2009 to December 2010 were retrospectively reviewed to identify the cytological characteristics that may have contributed to this discrepancy. Only 44 cases could be correlated histopathologically. RESULTS: Of the 64 cases analysed cytologically, 4 smears turned out to be unsatisfactory for evaluation, hence only rest 60 smears were evaluated. Out of the 32 cases which were given as cytologically benign, 28 were confirmed as benign on histology, while 04 cases turned out as malignant on histology. Of the 12 cases which were cytologically malignant, 2 turned out to be benign on histology. Taking histology as the "gold standard", the following data were obtained: specificity 92.8%, sensitivity 69.8%, diagnostic accuracy 84.5%, positive predictive value 83% and negative predictive value 83%. CONCLUSION: Despite inadequate samples obtained in some cases, FNAC should be done in the preoperative diagnosis of salivary gland lesions as it offers high diagnostic accuracy and specificity and an acceptable sensitivity.
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