Fine Needle Aspiration Biopsy for Improving the Diagnostic Accuracy of Cut Needle Biopsy of Focal Liver Lesions

França, Alex Vianey Callado; Valério, Helena Maria Giordano; Trevisan, Mirian; Escanhoela, C.A.F.; Sevá‐Pereira, Tiago; Zucoloto, Sérgio; Martinelli, Ana de Lôurdes Candolo; Soares, Elza Cotrim

doi:10.1159/000326529

Cited by 42 publications

(23 citation statements)

References 8 publications

(7 reference statements)

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“…[4][5][6][7][8][9][10][11] However, distinguishing HCC from metastatic carcinoma may pose a challenge, particularly if the tumor is poorly differentiated. Moreover, the treatment and prognosis of HCC and metastatic carcinoma are significantly different.…”

Section: Discussionmentioning

confidence: 99%

“…[5][6][7]10,11 Various ancillary methods such as immunocytochemistry have been used on FNAC to further improve the diagnostic accuracy. The specificity and positive predictive value of FNAC in the diagnosis of malignant liver lesions has been shown to be close to 100% in the majority of studies and the sensitivity of the FNAC procedure generally ranges from 67% to 100%, which is similar or better than that of core needle biopsy.…”

mentioning

confidence: 99%

“…[13][14][15][16] The main difficulties with cytologic diagnoses of coin lesions of the liver are distinguishing HCC from other carcinomas and identifying primary tumor sites from their liver metastases. 11,12 These problems may be overcome by the application of immunocytochemical panels that can be selected on the basis of the likelihood of suspected diagnoses, using a problemoriented approach. 12,17 Although the majority of investigations in the literature were performed on cell block material, immunocytochemistry can also be performed directly on smeared cells.…”

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confidence: 99%

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Immunocytochemical diagnosis of hepatocellular carcinoma and identification of carcinomas of unknown primary metastatic to the liver on fine-needle aspiration cytologies

Onofre

Pomjanski

Buckstegge

et al. 2007

Cancer

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We successfully synthesized an exfoliated styrene–butadiene–styrene triblock copolymer (SBS)/montmorillonite nanocomposite by anionic polymerization. Gel permeation chromatography showed that the introduction of organophilic montmorillonite (OMMT) resulted in a small high‐molecular‐weight fraction of SBS in the composites, leading to a slight increase in the weight‐average and number‐average molecular weights as well as the polydispersity index. The results from 1H‐NMR revealed that the introduction of OMMT almost did not affect the microstructure of the copolymer when the OMMT concentration was lower than 4 wt %. Transmission electron microscopy and X‐ray diffraction showed a completely exfoliated nanocomposite, in which both polystyrene and polybutadiene blocks entered the OMMT galleries, leading to the dispersion of OMMT layers on a nanoscale. The exfoliated nanocomposite exhibited higher thermal stability, glass‐transition temperature, elongation at break, and storage modulus than pure SBS. © 2005 Wiley Periodicals, Inc. J Appl Polym Sci, 2006

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Immunocytochemical diagnosis of hepatocellular carcinoma and identification of carcinomas of unknown primary metastatic to the liver on fine-needle aspiration cytologies

Onofre

Pomjanski

Buckstegge

et al. 2007

Cancer

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“…The frequency of metastatic liver lesions was higher than the frequencies reported by other studies. [3,21] Adenocarcinoma is the most common metastatic malignancy [3] and colonic adenocarcinoma is the commonest primary source for liver metastasis. [2] Pinto et al, [21] observed two cases of metastatic RCC.…”

Section: Observations and Results -mentioning

confidence: 99%

“…[3,21] Adenocarcinoma is the most common metastatic malignancy [3] and colonic adenocarcinoma is the commonest primary source for liver metastasis. [2] Pinto et al, [21] observed two cases of metastatic RCC. Cytological features of metastatic SCC were similar to those described by Kuo et al [1] The diagnostic accuracy of FNAC of liver in our study is on par with other series [Kuo et al, [1] (86.1%), Ramdas et al, [22] (87.5%), CochandPriollet et al, [23] (82.6%) and Franca et al, [24] (78%)].…”

Section: Observations and Results -mentioning

confidence: 99%

Ultra-Sound Guided Fine Needle Aspiration Cytology in Diagnosis of Space Occupying Lesions of Liver with Special Emphasis on Hepato-Cellular Carcinoma

Choudhary¹

2017

ijsrm

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BackgroundThe evaluation and management of various hepatic lesions is a common clinical problem and their appropriate clinical management depends on accurate diagnoses. Aims:To study the cytomorphological features of distinctive non-neoplastic and neoplastic lesions of the liver and to evaluate the sensitivity, specificity and diagnostic accuracy of ultrasonography (USG)-guided fine needle aspiration cytology (FNAC) in the diagnosis of liver diseases. Materials and Methods:The study was performed on patients who came with SOL in liver on ultrasonography, with normal range of prothrombin time index in SMS hospital, Jaipur. Procedure was performed on 172 patients from 2 January 2016 to 16 sepetember 2016. USG Guided FNAC performed after getting an informed consent & with the help of a radiologist. Relevant clinical and serological details were obtained from every patient . Results:The mean age at presentation 56.47 years (25-95 years), ratio was almost equal male to female , male patient were 91(52.9%) and female were 81(47.09%) out of 172. Adequate sample were 148(86.04) and inadequate sample were 24 out of 172 patients. The cytological diagnosis of non neoplastic lesion were total 10 in which granuloma 01(10%),liver abscess 4(40%),regenerating nodule 1(10%) , fatty liver 2(20%), cystic lesion 1(10%) and inflammatory lesions 1(10%). Neoplastic lesion were(135) more common than non neoplastic lesions . The majority of neoplastic lesion were metastatic tumor 104(77.03%), followed by primary HCC23 (17.3%), unclassified malignancies 4(2.96%), cholangiocarcinoma 4 (2.96%) out of total 135 cases. The overall diagnostic accuracy of FNAC was 97.82% with a sensitivity and specificity of 96.87 and 100% respectively. Conclusion -USG-guided FNAC of the liver is a safe, simple, cost-effective and accurate method for cytological diagnosis of hepatic diffuse, focal/nodular and cystic lesions with good sensitivity and specificity.

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Cytologic features and histologic correlations of microacinar and microtrabecular types of well-differentiated hepatocellular carcinoma in fine-needle aspiration biopsy

Yang

Tao

2003

Cancer

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Fine Needle Aspiration Biopsy for Improving the Diagnostic Accuracy of Cut Needle Biopsy of Focal Liver Lesions

Cited by 42 publications

References 8 publications

Immunocytochemical diagnosis of hepatocellular carcinoma and identification of carcinomas of unknown primary metastatic to the liver on fine-needle aspiration cytologies

Immunocytochemical diagnosis of hepatocellular carcinoma and identification of carcinomas of unknown primary metastatic to the liver on fine-needle aspiration cytologies

Ultra-Sound Guided Fine Needle Aspiration Cytology in Diagnosis of Space Occupying Lesions of Liver with Special Emphasis on Hepato-Cellular Carcinoma

Cytologic features and histologic correlations of microacinar and microtrabecular types of well-differentiated hepatocellular carcinoma in fine-needle aspiration biopsy

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