“…The panel of antibodies utilized to solve this differential diagnosis includes (tab. 2): cytokeratin 8-18 (Porcell , 2000)(Van Eyken P, 1988) Hep-Par1 (Leong AS , 1998) (Zimmerman , 2001) (Lugli A, 2004) (Minervini MI, 1997), glypican 3 (Yamauchi , 2005) (Zhu ZW et al 2001) (Capurro M et al 2003), cytokeratin 7 (Maeda , 1996) (Chu , 2000) (Durnez A et al 2006), cytokeratin 20 (Chu P, 2000) (Faa G , 1998), cytokeratin 19 (Maeda T, 1996) (Van Eyken P, 1988), CEA (Saad RS, 2004) (Goodman ZD, 2007) (Onofre AS , 2007) (Lau SK , 2002) and Alpha-fetoprotein (Onofre AS , 2007) (Lau SK , 2002) (Zhou L, 2006) (Wang L 2006). Among the numerous diagnostic immunohistochemical markers studied, alphafetoprotein (Wang L 2006), cytokeratin 7 (Durnez A et al 2006), cytokeratin 20 (Chu P et al 2000), cytokeratin 19 (Van Eyken P et al 1988), Hep-Par-1 (Zimmerman RL et al 2001) (Siddiqui MT et al 2002) and glypican 3 (Zhu ZW et al 2001) (Capurro M et al 2003) have been found to be the most valuable in the differential diagnosis between hepatocellular carcinoma and metastatic tumors.…”