Fine-needle aspiration biopsy as an auxiliary diagnostic tool on intraoral minor salivary gland adenoid cystic carcinoma

Netto, Juliana De Noronha Santos; Miranda, Águida Maria Menezes Aguiar; Silveira, Henrique Martins da; Santos, Teresa Cristina Ribeiro Bartholomeu dos; Pires, Fábio Ramôa

doi:10.1016/j.tripleo.2008.04.015

Cited by 13 publications

(9 citation statements)

References 16 publications

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“…Adenoid cystic carcinoma is considered to be the second most common malignant salivary tumor, presenting clinically as long-lasting swellings, which can be painful and ulcerated, involving more frequently intraoral minor salivary glands and the submandibular gland [13]. However, in both of our cases, the lesions presented as slow growing, painless masses with no surface changes or nerve involvement thus giving the impression of a benign pathology.…”

Section: Discussionmentioning

confidence: 65%

“…However, it is important to emphasize that although ACC has well defined cytologic diagnostic criteria, the literature reports FNAC false-negative results of up to 33 % and specificity of near 50 % for this tumor [13].…”

Section: Discussionmentioning

confidence: 98%

“…Owing to its homogeneous cellularity, about one-third of all ACC are cytologically interpreted as benign neoplasms, especially PA, and several authors have called attention to the importance of evaluating the stromal component of ACC, a hallmark of its cytologic differential diagnosis [13]. It is also necessary to include PA as cytologic differential diagnosis of ACC especially when there is hypercellularity, scanty matrix, when ductal lumen formation mimics cylinders or frank cylinderomatous foci are present.…”

Section: Discussionmentioning

confidence: 99%

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Salivary Gland Tumors: A Diagnostic Dilemma!

Peravali

Bhat

Upadya

et al. 2014

J. Maxillofac. Oral Surg.

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Salivary gland tumors generate considerable interest because of their heterogeneous and variable histology, grade of malignancy, and clinical behavior. Fine needle aspiration cytology (FNAC) is considered the first diagnostic modality for salivary neoplasms due to its ready availability and ease of performance. However it cannot always be relied upon in isolation, and should be used in conjunction with other investigations like incisional biopsy. We present two cases, which highlight the drawbacks of relying on FNAC alone, which resulted in misdiagnosis of adenoid cystic carcinoma as pleomorphic adenoma.

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Section: Discussionmentioning

confidence: 65%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

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Salivary Gland Tumors: A Diagnostic Dilemma!

Peravali

Bhat

Upadya

et al. 2014

J. Maxillofac. Oral Surg.

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“…Similar issues are found in interpreting FNA biopsies of these tumors. Although good results with FNAC have been reported, less information is to be obtained from individual cells, without the tissue architecture . Some tumors present at an advanced stage and the biopsy may be the only tissue sample obtained.…”

Section: Introductionmentioning

confidence: 99%

Recent trends in the management of minor salivary gland carcinoma

et al. 2013

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The current management of minor salivary gland cancer is reviewed. These malignancies often present as a submucosal swelling and have been reported at all anatomic subsites of the head and neck. Modern imaging is essential in evaluating the location and the anatomic extent of disease. An incisional or punch biopsy determines the histologic type and grade. Recent advances in molecular biology have yielded diagnostic and potential therapeutic targets that may change our treatment in the future. Complete resection is the treatment of choice. Unfortunately, given the proximity of essential structures, the need to balance functional and cosmetic with oncologic consequences can interfere with an adequate "clear margin." The neck should be treated when there is evidence of regional metastasis or when subclinical metastatic risk exceeds 15%. Surgery alone cures most low-stage, low-grade tumors, all other stages and grades require postoperative radiotherapy. Systemic treatment for locoregional and distant failure remains disappointing.

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“…Se a lâmina foi fixada com álcool etílico, a coloração mais utilizada é a de Papanicolaou e seguida pela de Hematoxilina-Eosina (HE). A coloração de Papanicolaou parece dar um contraste mais refinado na lâmina, alguns patologistas preferem a coloração de HE por sua familiarização (Kline, 1988;Amedee;Dhurandhar, 2001;Safneck et al, 2001;Netto et al, 2008).…”

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Análise comparativa da punção aspirativa por agulha fina (PAAF) em relação a biópsia em cavidade oral e região de cabeça e pescoço

Santos¹

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RESUMO O presente estudo teve como objetivos avaliar a sensibilidade, a especificidade e a acurácia da Punção Aspirativa por Agulha Fina (PAAF) em nódulos submucosos da cavidade bucal e da região de cabeça e pescoço como ferramenta auxiliar de diagnóstico. Foram selecionados 50 pacientes consecutivamente que procuraram a Clínica da Disciplina de Estomatologia Clínica da FOUSP, portadores de lesões em boca e em região de cabeça e pescoço. O material obtido pela PAAF foi enviado a um mesmo patologista apenas com o diagnóstico clínico e após a emissão do laudo da PAAF o laudo do anátomo patológico era emitido servindo como padrão ouro. Após os cálculos, o resultado da sensibilidade foi de 75%, a especificidade foi de 96%, a acurácia foi de 58,8%, o valor preditivo positivo foi de 86% e o valor preditivo negativo foi de 93%. A significância foi estabelecida para 5% e o teste usado foi o teste de Kappa com valor de P<0,001 e um teste qui-quadrado, com valor de P=0,788. Pela análise dos resultados a PAAF teve uma alta sensibilidade para identificar lesões malignas, uma alta especificidade para identificar lesões benignas e uma baixa acurácia para se obter um diagnóstico definitivo. Palavras Chave: PAAF. Diagnóstico citológico. Biópsia por agulha fina. Santos APC. Comparative analysis of Fine Needle Aspiration Biopsy (FNAB) versus biopsy in oral cavity and head and neck region [dissertation].

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Fine-needle aspiration biopsy as an auxiliary diagnostic tool on intraoral minor salivary gland adenoid cystic carcinoma

Cited by 13 publications

References 16 publications

Salivary Gland Tumors: A Diagnostic Dilemma!

Salivary Gland Tumors: A Diagnostic Dilemma!

Recent trends in the management of minor salivary gland carcinoma

Análise comparativa da punção aspirativa por agulha fina (PAAF) em relação a biópsia em cavidade oral e região de cabeça e pescoço

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