Fine needle aspiration biopsy: an investigative tool for iris metastasis

Abstract

Cook C, Koretz JF. Methods to obtain quantitative parametric descriptions of the optical surfaces of the human crystalline lens from Scheimpflug slit-lamp images. I. Image processing methods.

Don’t it make my blue eyes brown: heterochromia and other abnormalities of the iris

“…In these circumstances a fine-needle aspiration, or punch biopsy, may be of value. 265,[274][275][276][277] Melanocytic tumours of the iris stroma Naevi. Although iris naevi are undoubtedly common, precise estimates of their prevalence within the general population are lacking.…”

Intraocular Biopsy and ImmunoMolecular Pathology for “Unmasking” Intraocular Inflammatory Diseases

“…Iris and ciliary body biopsy may also be diagnostic in masquerade syndromes, when lymphoma, the most common malignant orbital tumor, or metastasis, “hidden” by a reactive inflammation, are suspected [55,56,57]. Iris and ciliary body can be infiltrated by metastatic adenocarcinoma (from the breast, lung, or gastro-intestinal tract), systemic lymphoma, or by PVRL, which is rarely found here as the first site of presentation [43,52,55,56,57].…”

“…Iris and ciliary body biopsy may also be diagnostic in masquerade syndromes, when lymphoma, the most common malignant orbital tumor, or metastasis, “hidden” by a reactive inflammation, are suspected [55,56,57]. Iris and ciliary body can be infiltrated by metastatic adenocarcinoma (from the breast, lung, or gastro-intestinal tract), systemic lymphoma, or by PVRL, which is rarely found here as the first site of presentation [43,52,55,56,57]. The involvement of the anterior segment manifests with abnormal iris vessels or nodules, hyphema, iridocyclitis, secondary glaucoma (including open angle, closed angle, or neovascular), or clinically visible iris/ciliary body lymphoid infiltration [56,58,59,60] and can precede detection of subretinal infiltrates [52,61].…”