Fine Morphology of the Tectorial Membrane: Its Relationship to the Organ of Corti

Lim, David J.

doi:10.1001/archotol.1972.00770090321001

Cited by 206 publications

(74 citation statements)

References 33 publications

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“…The TM is thought to be secreted during development by the cells of the GER and LER of Kölliker's organ (Lim, 1972(Lim, , 1977Lim and Anniko, 1985). It has been proposed that the TM is maintained in adults by the interdental cells (Iurato, 1962;Lim, 1969Lim, , 1970Prieto et al, 1990aPrieto et al, , 1991.…”

Section: Tmmentioning

confidence: 99%

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Distribution of glycoconjugates during cochlea development in mice: Light microscopic lectin study

Rueda¹,

Cantos²,

Lim³

2003

Anat. Rec.

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During development, different epithelial cells in the mouse cochlea express different cell surface glycoconjugates, which may reflect membrane specialization. Some of the lectins tested in this study (SBA, succ-WGA, and PSA) labeled the sensory cells of the cochlea around birth. Other lectins (WGA, Con A, RCA-II, and PHA-E) labeled surfaces of the sensory cells, particularly the stereocilia, from early stages of development (gestation day (GD) 16) through 21 days after birth. These may be adhesion molecules needed to attach the newly forming tectorial membrane (TM) to the stereocilia. Lectin staining of the developing TM revealed that the substructures of the TM are biochemically distinct. Lectin staining also showed the temporal sequence of the expression of cytoplasmic glycoconjugates of the cochlear epithelium during development. Biochemical changes during development are probably the result of different cells being involved in the production of glycoconjugates, and may have functional significance, specifically with regard to the expression of adhesion and/or signaling molecules. Anat Rec Part A 274A: 923-933, 2003.

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Section: Tmmentioning

confidence: 99%

“…It is well known that the TM develops in stages and is formed from two different parts: the major TM (MTM) and the minor TM (mTM) (Lim, 1972). During early stages of development, the MTM covers only the cells of the greater epithelial ridge (GER) and the IHCs, while the mTM covers the OHCs.…”

mentioning

confidence: 99%

Distribution of glycoconjugates during cochlea development in mice: Light microscopic lectin study

Rueda¹,

Cantos²,

Lim³

2003

Anat. Rec.

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“…IHC are the sensors of vibratory patterns established by complex interactions among the BM, TM, and organ of Corti. Because both morphological and physiological evidence indicates that the IHC stereocilia are not firmly connected to the TM (13,14), they are not participants in the cochlear amplification feedback loop but rather are its beneficiaries.…”

mentioning

confidence: 99%

“…The tips of the tallest rows of OHC stereocilia insert into shallow pits on the underside of the TM (14). The connection is stronger than a mere insertion because upon mechanical removal of the TM, stereocilia occasionally are avulsed and maintain their TM attachments (14).…”

mentioning

confidence: 99%

“…The connection is stronger than a mere insertion because upon mechanical removal of the TM, stereocilia occasionally are avulsed and maintain their TM attachments (14). Although the molecular basis of this attachment is obscure, it is pertinent that the bottom layer of the TM, which is in contact with OHC stereocilia, is different from its main collagenous body.…”

mentioning

confidence: 99%

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Carcinoembryonic antigen-related cell adhesion molecule 16 interacts with α-tectorin and is mutated in autosomal dominant hearing loss (DFNA4)

Zheng

Miller

Yang

et al. 2011

Proc. Natl. Acad. Sci. U.S.A.

100

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We report on a secreted protein found in mammalian cochlear outer hair cells (OHC) that is a member of the carcinoembryonic antigen-related cell adhesion molecule (CEACAM) family of adhesion proteins. Ceacam16 mRNA is expressed in OHC, and its protein product localizes to the tips of the tallest stereocilia and the tectorial membrane (TM). This specific localization suggests a role in maintaining the integrity of the TM as well as in the connection between the OHC stereocilia and TM, a linkage essential for mechanical amplification. In agreement with this role, CEACAM16 colocalizes and coimmunoprecipitates with the TM protein α-tectorin. In addition, we show that mutation of CEACAM16 leads to autosomal dominant nonsyndromic deafness (ADNSHL) at the autosomal dominant hearing loss (DFNA4) locus. In aggregate, these data identify CEACAM16 as an α-tectorin-interacting protein that concentrates at the point of attachment of the TM to the stereocilia and, when mutated, results in ADNSHL at the DFNA4 locus.cochlea | deafness genes

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Davis--1961 Revisited: Signal Transmission in the Cochlear Hair Cell-Nerve Junction

Tonndorf¹

1975

Archives of Otolaryngology - Head and Neck Surgery

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Fine Morphology of the Tectorial Membrane: Its Relationship to the Organ of Corti

Cited by 206 publications

References 33 publications

Distribution of glycoconjugates during cochlea development in mice: Light microscopic lectin study

Distribution of glycoconjugates during cochlea development in mice: Light microscopic lectin study

Carcinoembryonic antigen-related cell adhesion molecule 16 interacts with α-tectorin and is mutated in autosomal dominant hearing loss (DFNA4)

Davis--1961 Revisited: Signal Transmission in the Cochlear Hair Cell-Nerve Junction

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