Fine-mapping quantitative trait loci affecting murine external ear tissue regeneration in the LG/J by SM/J advanced intercross line

Cheverud, James M.; Lawson, Heather A.; Bouckaert, Kristine; Kossenkov, Andrew V.; Showe, Louise C.; Cort, Laura; Blankenhorn, Elizabeth P.; Bedelbaeva, Khamilia; Gourevitch, Dmitri; Zhang, Y.; Heber‐Katz, Ellen

doi:10.1038/hdy.2013.133

Cited by 28 publications

(41 citation statements)

References 78 publications

(88 reference statements)

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“…This is consistent with earlier studies establishing that enhanced ear wound closure in MRL/MpJ mice is a complex genetic trait involving the interaction of multiple genetic factors [55–58]. Recent fine-mapping studies on LG/J (the parental strain of MRL/MpJ) and SM/J intercross mice narrowed down the loci intervals for the ear wound closure and provided candidate genes for further analysis [29,30]. For heritability studies, the use of inbred strains is preferred because any phenotypic variation detected is due to different combinations of each parental genome without the confounding influence of different genetic backgrounds that outbred strains would have [59].…”

Section: Mapping the Articular Cartilage Healing Traitsupporting

confidence: 89%

“…Cheverud et al [30], using an advanced intercross (AI) line for healing, confirmed previously identified healing loci on chromosomes 9, 10, 11, 14 and 18 [29,81] and identified new loci on chromosomes 1, 7, 12 and 13 [30]. Overall, 19 intervals were associated with healing.…”

Section: Several Distinct Mechanisms Appear To Promote Articular Cmentioning

confidence: 59%

“…The MRL/MpJ strain was derived by selective breeding from the LG/J strain and the two strains share 75% of their genomes [28]. Notably, ear hole tissue regeneration has also been demonstrated in the parental LG/J strain [29,30]. …”

Section: Emerging Evidence For Mammalian Tissue Regenerationmentioning

confidence: 99%

“…Kif23 which encodes the kinesin-like protein KIF23, is a motor molecule involved in cytokinesis and developmental processes important for regeneration in amphibians and fish. It localizes to the midzone during cytokinesis and was present in the regeneration blastema and epidermis of healer mice, but was absent in non-healer SM/J tissues [30]. …”

Section: Several Distinct Mechanisms Appear To Promote Articular Cmentioning

confidence: 99%

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Enhanced cartilage repair in ‘healer’ mice—New leads in the search for better clinical options for cartilage repair

Fitzgerald

2017

Seminars in Cell & Developmental Biology

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Adult articular cartilage has a poor capacity to undergo intrinsic repair. Current strategies for the repair of large cartilage defects are generally unsatisfactory because the restored cartilage does not have the same resistance to biomechanical loading as authentic articular cartilage and degrades over time. Recently, an exciting new research direction, focused on intrinsic cartilage regeneration rather than fibrous repair by external means, has emerged. This review explores the new findings in this rapidly moving field as they relate to the clinical goal of restoration of structurally robust, stable and non-fibrous articular cartilage following injury.

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Section: Mapping the Articular Cartilage Healing Traitsupporting

confidence: 89%

Section: Several Distinct Mechanisms Appear To Promote Articular Cmentioning

confidence: 59%

Section: Emerging Evidence For Mammalian Tissue Regenerationmentioning

confidence: 99%

Section: Several Distinct Mechanisms Appear To Promote Articular Cmentioning

confidence: 99%

See 2 more Smart Citations

Enhanced cartilage repair in ‘healer’ mice—New leads in the search for better clinical options for cartilage repair

Fitzgerald

2017

Seminars in Cell & Developmental Biology

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“…(see Figure 2). Another piece of evidence came from genetic mapping studies of MRL/LG vs non-regenerating mice identifying the candidate gene Rnf7 (64), part of an E3-ligase complex, as necessary for HIF-1α degradation (65), and which exhibited very low expression levels in regenerating MRL murine tissue (64). …”

Section: Hif-1α In Regenerationmentioning

confidence: 99%

Oxygen, Metabolism, and Regeneration: Lessons from Mice

Heber‐Katz

2017

Trends in Molecular Medicine

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The discovery that the Murphy Roths Large (MRL) mouse strain is a fully competent, epimorphic tissue regenerator, proved that the machinery of regeneration was preserved through evolution from hydra, to salamanders, to mammals. Such concepts have allowed translation of the biology of amphibians -- and their ability to regenerate -- to a mammalian context. In particular, the ancient hypoxia inducible factor (HIF-1α) pathway, operating through prolyl hydroxylase domain proteins (PHDs), was identified as a central player in mouse regeneration. Thus, the possibility of targeting PHDs or other HIF-1α modifiers to effectively recreate the amphibian regenerative state has emerged. We posit that these regenerative pathways are critical in mammals. Moreover, the current approved use of PHD inhibitors in the clinic should allow fast-track translation from mouse studies to drug-based regenerative therapy in humans.

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Effects of High-Fat Diet and Body Mass on Bone Morphology and Mechanical Properties in 1100 Advanced Intercross Mice

Silva

Eekhoff

Patel

et al. 2019

Journal of Bone and Mineral Research

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Obesity is generally protective against osteoporosis and bone fracture. However, recent studies indicate that the influence of obesity on the skeleton is complex and can be detrimental. We evaluated the effects of a high‐fat, obesogenic diet on the femur and radius of 1100 mice (males and females) from the Large‐by‐Small advanced intercross line (F34 generation). At age 5 months, bone morphology was assessed by microCT and mechanical properties by three‐point bending. Mice raised on a high‐fat diet had modestly greater cortical area, bending stiffness, and strength. Size‐independent material properties were unaffected by a high‐fat diet, indicating that diet influenced bone quantity but not quality. Bone size and mechanical properties were strongly correlated with body mass. However, the increases in many bone traits per unit increase in body mass were less in high‐fat diet mice than low‐fat diet mice. Thus, although mice raised on a high‐fat diet have, on average, bigger and stronger bones than low‐fat‐fed mice, a high‐fat diet diminished the positive relationship between body mass and bone size and whole‐bone strength. The findings support the concept that there are diminishing benefits to skeletal health with increasing obesity. © 2019 American Society for Bone and Mineral Research.

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Fine-mapping quantitative trait loci affecting murine external ear tissue regeneration in the LG/J by SM/J advanced intercross line

Cited by 28 publications

References 78 publications

Enhanced cartilage repair in ‘healer’ mice—New leads in the search for better clinical options for cartilage repair

Enhanced cartilage repair in ‘healer’ mice—New leads in the search for better clinical options for cartilage repair

Oxygen, Metabolism, and Regeneration: Lessons from Mice

Effects of High-Fat Diet and Body Mass on Bone Morphology and Mechanical Properties in 1100 Advanced Intercross Mice

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