Fine mapping of the polled locus to a 1-Mb region on bovine Chromosome 1q12

Drögemüller, Cord; Wöhlke, Anne; Mömke, S.; Distl, O.

doi:10.1007/s00335-005-0016-0

Cited by 46 publications

(41 citation statements)

References 12 publications

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“…The gene responsible for horns has not yet been characterized, but the causative mutation has been localized to a region of $1 Mbp on the proximal end of BTA1 (Brenneman et al 1996;Drögemüller et al 2005). The most recent data indicate that the polled gene lies between bp 600,000 and 1,600,000 (Drö gemü ller et al 2005). CLL 1j were therefore calculated for a subset of the four breeds with significant numbers of polled animals (i.e., Angus, Red Angus, Hereford, and Limousin).…”

Section: Permutation Testmentioning

confidence: 99%

Identification of Selection Signatures in Cattle Breeds Selected for Dairy Production

et al. 2010

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The genomics revolution has spurred the undertaking of HapMap studies of numerous species, allowing for population genomics to increase the understanding of how selection has created genetic differences between subspecies populations. The objectives of this study were to (1) develop an approach to detect signatures of selection in subsets of phenotypically similar breeds of livestock by comparing single nucleotide polymorphism (SNP) diversity between the subset and a larger population, (2) verify this method in breeds selected for simply inherited traits, and (3) apply this method to the dairy breeds in the International Bovine HapMap (IBHM) study. The data consisted of genotypes for 32,689 SNPs of 497 animals from 19 breeds. For a given subset of breeds, the test statistic was the parametric composite log likelihood (CLL) of the differences in allelic frequencies between the subset and the IBHM for a sliding window of SNPs. The null distribution was obtained by calculating CLL for 50,000 random subsets (per chromosome) of individuals. The validity of this approach was confirmed by obtaining extremely large CLLs at the sites of causative variation for polled (BTA1) and black-coat-color (BTA18) phenotypes. Across the 30 bovine chromosomes, 699 putative selection signatures were detected. The largest CLL was on BTA6 and corresponded to KIT, which is responsible for the piebald phenotype present in four of the five dairy breeds. Potassium channel-related genes were at the site of the largest CLL on three chromosomes (BTA14, -16, and -25) whereas integrins (BTA18 and -19) and serine/arginine rich splicing factors (BTA20 and -23) each had the largest CLL on two chromosomes. On the basis of the results of this study, the application of population genomics to farm animals seems quite promising. Comparisons between breed groups have the potential to identify genomic regions influencing complex traits with no need for complex equipment and the collection of extensive phenotypic records and can contribute to the identification of candidate genes and to the understanding of the biological mechanisms controlling complex traits.

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Section: Permutation Testmentioning

confidence: 99%

Identification of Selection Signatures in Cattle Breeds Selected for Dairy Production

et al. 2010

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“…Polledness (P) is dominant over horned (p). The gene is located at the proximal end of Bovine chromosome 1 (Brenneman et al, 1996, Drogemuller et al, 2005, Georges et al, 1993, Harlizius et al, 1997, Schmutz et al, 1995. The exact molecular nature of the polled allele remained unknown for a long time, but was recently identified as two alleles: a 202 bp insertion-deletion in most breeds, and a 260 bp haplotype in Holstein cattle.…”

Section: Introductionmentioning

confidence: 99%

Breeding for polledness in Holstein cattle

2015

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“…In the past years, the position of the POLLED locus on BTA1 was refined [11,12] and candidate causal mutations were identified [2,4,5]. Recently, Medugorac et al [4] demonstrated the existence of at least two different alleles at the POLLED locus in cattle.…”

Section: Introductionmentioning

confidence: 99%

The 80-kb DNA duplication on BTA1 is the only remaining candidate mutation for the polled phenotype of Friesian origin

et al. 2014

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BackgroundThe absence of horns, called polled phenotype, is the favored trait in modern cattle husbandry. To date, polled cattle are obtained primarily by dehorning calves. Dehorning is a practice that raises animal welfare issues, which can be addressed by selecting for genetically hornless cattle. In the past 20 years, there have been many studies worldwide to identify unique genetic markers in complete association with the polled trait in cattle and recently, two different alleles at the POLLED locus, both resulting in the absence of horns, were reported: (1) the Celtic allele, which is responsible for the polled phenotype in most breeds and for which a single candidate mutation was detected and (2) the Friesian allele, which is responsible for the polled phenotype predominantly in the Holstein-Friesian breed and in a few other breeds, but for which five candidate mutations were identified in a 260-kb haplotype. Further studies based on genome-wide sequencing and high-density SNP (single nucleotide polymorphism) genotyping confirmed the existence of the Celtic and Friesian variants and narrowed down the causal Friesian haplotype to an interval of 145 kb.ResultsAlmost 6000 animals were genetically tested for the polled trait and we detected a recombinant animal which enabled us to reduce the Friesian POLLED haplotype to a single causal mutation, namely a 80-kb duplication. Moreover, our results clearly disagree with the recently reported perfect co-segregation of the POLLED mutation and a SNP at position 1 390 292 bp on bovine chromosome 1 in the Holstein-Friesian population.ConclusionWe conclude that the 80-kb duplication, as the only remaining variant within the shortened Friesian haplotype, represents the most likely causal mutation for the polled phenotype of Friesian origin.

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Fine mapping of the polled locus to a 1-Mb region on bovine Chromosome 1q12

Cited by 46 publications

References 12 publications

Identification of Selection Signatures in Cattle Breeds Selected for Dairy Production

Identification of Selection Signatures in Cattle Breeds Selected for Dairy Production

Breeding for polledness in Holstein cattle

The 80-kb DNA duplication on BTA1 is the only remaining candidate mutation for the polled phenotype of Friesian origin

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