Fine-mapping of HLA associations with chronic lymphocytic leukemia in US populations

Gragert, Loren; Fingerson, Stephanie; Albrecht, Mark; Maiers, Martin; Kalaycio, Matt; Hill, Brian T.

doi:10.1182/blood-2014-02-558767

Cited by 38 publications

(56 citation statements)

References 55 publications

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“…El haplotipo DRB4* muestra varios alelos predisponentes en esta población tales como los alelos observados en familias DRB1*04, DRB1*07 y DRB1*09. 20 Solamente el DRB1*13 coincide como protector asociado negativamente a la LMC en pacientes venezolanos concordando con lo observado en pacientes LLC de Estados Unidos. 20 Una fuerte asociación HLA-DQB1*0201, -DQB1*0302, -DQB1*0303 y -DRB1*1302 fue reportada en 824 casos de pacientes LLA-BCP confrontados con 4.737 controles en la población del Reino Unido.…”

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“…20 Solamente el DRB1*13 coincide como protector asociado negativamente a la LMC en pacientes venezolanos concordando con lo observado en pacientes LLC de Estados Unidos. 20 Una fuerte asociación HLA-DQB1*0201, -DQB1*0302, -DQB1*0303 y -DRB1*1302 fue reportada en 824 casos de pacientes LLA-BCP confrontados con 4.737 controles en la población del Reino Unido. 21,22 En pacientes mexicanos los alelos HLA DRB1*01:02, DQB1*02:01/02 y DPB1*04:01 resultaron protectores para la LLA, el alelo DQB1*02 resultó protector también para las LMC en venezolanos.…”

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“…23 En pacientes caucásicos de Estados Unidos con leucemia linfoide crónica (LLC) se describen los alelos HLA-DQB1*05:04 asociados positivamente mientras que el alelo DRB1*04:03 se encuentra asociado negativamente y actúa como protector en las LLC en dicha población; el alelo DRB1*09:01 se encuentra también asociado a las LLC en pacientes afroamericanos. 20 En correspondencia con lo anterior, el haplotipo DRB1*04/DPA1*02:01 se asoció negativamente a las LLA en venezolanos.…”

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“…20 Los pacientes LLC judíos ashkenazi, muestran asociación positiva con los alelos DRB4*01:01, DRB1*04:02 y DQB1*03:02. 20 Por el contrario, el alelo DQB1*04 resultó asociado positivamente con la LLA y el DQB1*05 negativamente en pacientes LLA venezolanos, mientras que el DQB1*02 aparece asociado negativamente a la LMC.…”

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HLA DRB1, DQB1, DPA1, and DPB1 and their association with the pathogenesis of leukemia in the population of Venezuela

Rivera

Echeverría

Salcedo

et al. 2016

RAM

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HLA DRB1, DQB1, DPA1, and DPB1 and their association with the pathogenesis of leukemia in the population of Venezuela

Rivera

Echeverría

Salcedo

et al. 2016

RAM

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“…Matching organ donors with recipients on polymorphisms in HLA genes has had great clinical impact in kidney and bone marrow transplantation (34), and HLA polymorphisms have also been linked to numerous autoimmune diseases, demonstrating some of the strongest genetic factors for those diseases (35). HLA polymorphisms have been linked to risk of cancer, but more work is needed to better explore those associations using fine mapping (36).…”

Section: Genomic/gwas Measures Of Immune Responsementioning

confidence: 99%

Understanding the Role of the Immune System in the Development of Cancer: New Opportunities for Population-Based Research

Michaud

Houseman

Marsit

et al. 2015

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Understanding the precise role of the immune system in cancer has been hindered by the complexity of the immune response and challenges in measuring immune cell types in health and disease in the context of large epidemiologic studies. In this review, we present the rationale to study immunity in cancer and highlight newly available tools to further elucidate the epidemiologic factors driving individual variation in the immune response in cancer. Here, we summarize key studies that have evaluated the role of immunologic status on risk of cancer, discuss tools that have been used in epidemiologic studies to measure immune status, as well as new evolving methodologies where application to epidemiology is becoming more feasible. We also encourage further development of novel emerging technologies that will continue to enable prospective assessment of the dynamic and complex role played by the immune system in cancer susceptibility. Finally, we summarize characteristics and environmental factors that affect the immune response, as these will need to be considered in epidemiologic settings. Overall, we consider the application of a systems biologic approach and highlight new opportunities to understand the immune response in cancer risk.

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Single haplotype admixture models using large scale HLA genotype frequencies to reproduce human admixture

et al. 2019

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The Human Leukocyte Antigen (HLA) is the most polymorphic region in humans. Anthropologists use HLA to trace populations' migration and evolution. However, recent admixture between populations masks the ancestral haplotype frequency distribution.We present an HLA-based method based on high-resolution HLA haplotype frequencies to resolve population admixture using a non-negative matrix factorization formalism and validated using haplotype frequencies from 56 populations. The result is a minimal set of original populations decoding roughly 90% of the total variance in the studied admixtures. These original populations agree with the geographical distribution, phylogenies and recent admixture events of the studied groups.With the growing population of multi-ethnic individuals, the matching process for stem-cell and solid organ transplants is becoming more challenging. The presented algorithm provides a framework that facilitates the breakdown of highly admixed populations into original groups, which can be used to better match the rapidly growing population of multi-ethnic individuals worldwide.

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Fine-mapping of HLA associations with chronic lymphocytic leukemia in US populations

Abstract: Key Points Polymorphisms in HLA genes may impact the ability of the immune system to detect malignant cells and direct T cells to eliminate them. Several HLA alleles and haplotypes are associated with development of chronic lymphocytic leukemia across different US populations.

Cited by 38 publications

References 55 publications

HLA DRB1, DQB1, DPA1, and DPB1 and their association with the pathogenesis of leukemia in the population of Venezuela

HLA DRB1, DQB1, DPA1, and DPB1 and their association with the pathogenesis of leukemia in the population of Venezuela

Understanding the Role of the Immune System in the Development of Cancer: New Opportunities for Population-Based Research

Single haplotype admixture models using large scale HLA genotype frequencies to reproduce human admixture

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Fine-mapping of HLA associations with chronic lymphocytic leukemia in US populations

Abstract: Key Points Polymorphisms in HLA genes may impact the ability of the immune system to detect malignant cells and direct T cells to eliminate them. Several HLA alleles and haplotypes are associated with development of chronic lymphocytic leukemia across different US populations.

Cited by 38 publications

References 55 publications

HLA DRB1*, DQB1*, DPA1*, and DPB1* and their association with the pathogenesis of leukemia in the population of Venezuela

HLA DRB1*, DQB1*, DPA1*, and DPB1* and their association with the pathogenesis of leukemia in the population of Venezuela

Understanding the Role of the Immune System in the Development of Cancer: New Opportunities for Population-Based Research

Single haplotype admixture models using large scale HLA genotype frequencies to reproduce human admixture

Contact Info

Product

Resources

About

HLA DRB1, DQB1, DPA1, and DPB1 and their association with the pathogenesis of leukemia in the population of Venezuela

HLA DRB1, DQB1, DPA1, and DPB1 and their association with the pathogenesis of leukemia in the population of Venezuela