The Human Leukocyte Antigen (HLA) is the most polymorphic region in humans. Anthropologists use HLA to trace populations' migration and evolution. However, recent admixture between populations masks the ancestral haplotype frequency distribution.We present an HLA-based method based on high-resolution HLA haplotype frequencies to resolve population admixture using a non-negative matrix factorization formalism and validated using haplotype frequencies from 56 populations. The result is a minimal set of original populations decoding roughly 90% of the total variance in the studied admixtures. These original populations agree with the geographical distribution, phylogenies and recent admixture events of the studied groups.With the growing population of multi-ethnic individuals, the matching process for stem-cell and solid organ transplants is becoming more challenging. The presented algorithm provides a framework that facilitates the breakdown of highly admixed populations into original groups, which can be used to better match the rapidly growing population of multi-ethnic individuals worldwide.
14The Human Leukocyte Antigen (HLA) is the most polymorphic region in humans. Anthropologists 15 use HLA to trace populations' migration and evolution. However, recent admixture between populations 16 masks the ancestral haplotype frequency distribution. 17We present an HLA-based method based on high-resolution HLA haplotype frequencies to 18 resolve population admixture using a non-negative matrix factorization formalism and validated using 19 haplotype frequencies from 56 populations. The result is a minimal set of original populations decoding 20 roughly 90% of the total variance in the studied admixtures. These original populations agree with the 21 geographical distribution, phylogenies and recent admixture events of the studied groups. 22With the growing population of multi-ethnic individuals, the matching process for stem-cell and 23 solid organ transplants is becoming more challenging. The presented algorithm provides a framework 24 that facilitates the breakdown of highly admixed populations into original groups, which can be used to 25 better match the rapidly growing population of multi-ethnic individuals worldwide. 26
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