Fine mapping a quantitative trait locus affecting ovulation rate in swine on chromosome 81

Campbell, Emily M.; Nonneman, Dan; Rohrer, Gary A.

doi:10.2527/2003.8171706x

Cited by 47 publications

(39 citation statements)

References 34 publications

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“…Braunschweig et al (2001) refined the genetic map by the use of 29 markers and confirmed the QTL at the centromere region of SSC8. Campbell et al (2003) narrowed the region at the telomeric end of the short arm on SSC8 using gene and microsatellite markers within the first 27 cM and confirmed and narrowed the QTL found by Rohrer et al (1999). Additional significant QTL for ovulation rate were found on SSC9 (Cassady et al, 2001), SSC13 and SSC15 (Rathje et al, 1997).…”

Section: Ovulation Ratesupporting

confidence: 53%

QTL and candidate genes for fecundity in sows

Buske

Sternstein

Brockmann

2006

Animal Reproduction Science

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Fecundity in pigs is a trait of major economic interest but low heritability. For the improvement of fecundity, genetic markers for selection are desirable and therefore, several searches for genetic variation influencing fecundity have been performed. The aim of this review is to compare and to evaluate all published QTL analyses and candidate gene approaches concerning reproductive traits in sows. For this purpose, we present a comprehensive cytogenetic map comprising 54 QTL and 11 candidate genes with influence on reproductive traits. The evaluation and comparison of the results showed similarities, but also marked differences among studies. Reasons for different results are multicausal and are due to differences between resource populations, number of evaluated animals, mating systems, measured phenotypical traits and environmental influences. We could show that chromosome 8 and to a lower extend chromosome 7 are the most important chromosomes with regard to reproductive traits in pigs. For further research, fine mapping of the identified QTL regions is necessary in order to confirm and to narrow the most likely chromosomal intervals. Although difficult to perform, an advance would be a standardization of the experimental setup in particular, in respect to the collection of phenotypic data. Furthermore, we suggest to publish the information on further identified QTL and candidate genes as comprehensive and accurate as possible in order to allow a more transparent comparison and collation of the results.

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Section: Ovulation Ratesupporting

confidence: 53%

QTL and candidate genes for fecundity in sows

Buske

Sternstein

Brockmann

2006

Animal Reproduction Science

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“…Five QTL affecting age at puberty have been reported in only two studies (Rohrer et al, 1999;Cassady et al, 2001). Results for ovulation rate are slightly more numerous, as 14 chromosomal regions associated with variations in OR are reported in PiqQTLdb (Rohrer et al, 1999;Wilkie et al, 1999;Cassady et al, 2001;Campbell et al, 2003). Regarding litter size, 12 QTL located on 10 different chromosomes have been reported (Rathje et al, 1997;Cassady et al, 2001;de Koning et al, 2001;Noguera et al, 2006;Tribout et al, 2008), of which only those reported by Noguera et al (2006) reached a genome-wide significance level (P , 0.05).…”

Section: Discussionmentioning

confidence: 98%

Detection of quantitative trait loci for teat number and female reproductive traits in Meishan × Large White F2 pigs

Bidanel

Rosendo

Iannuccelli

et al. 2008

Animal

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A quantitative trait locus (QTL) analysis of female reproductive data from a three-generation experimental cross between Meishan (MS) and Large White (LW) pig breeds is presented. Six F1 boars and 23 F1 sows, progeny of six LW boars and six MS sows, produced 573 F2 females and 530 F2 males. Six traits, i.e. teat number (TN), age at puberty (AP), ovulation rate (OR), weight at mating (WTM), number of viable embryos (NVE) and embryo survival (ES) at 30 days of gestation were analysed. Animals were genotyped for a total of 137 markers covering the entire porcine genome. Analyses were carried out based on interval mapping methods, using a line-cross (LC) regression and a half-full sib (HFS) maximum likelihood test. Genome-wide (GW) highly significant (P , 0.001) QTL were detected for WTM on SSC 7 and for AP on SSC 13. They explained, respectively, 14.5% and 8.9% of the trait phenotypic variance. Other GW significant (P , 0.05) QTL were detected for TN on SSC 3, 7, 8, 16 and 17, for OR on SSC 4 and 5, and for ES on SSC 9. Two additional chromosome-wide significant (P , 0.05) QTL were detected for TN, three for WTM, four for AP, three for OR, three for NVE and two for ES. With the exception of the two above-mentioned loci, the QTL explained from 1.2% to 4.6% of trait phenotypic variance. QTL alleles were in most cases not fixed in the grand-parental populations and Meishan alleles were not systematically associated with higher reproductive performance.

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“…Interestingly, murine chromosome 5 was shown to be homologous to bovine chromosomes 4, 6, 17, a n d 2 5 , p a r ti c u l a r l y t o c h r o m o s o m e 6 ( h t t p :/ / bos.cvm.tamu.edu). On the other hand, in pigs, QTL studies for reproduction traits including ovulation rate, litter size, and prenatal survival have also been carried out extensively, and many QTLs were identified on swine chromosome 8 [1,3,10,26]. Also, swine chromosome 8 was shown to be homologous to portions of murine chromosome 5 (http:// iowa.thearkdb.org), as well as murine chromosomes 3 and 8.…”

Section: Discussionmentioning

confidence: 99%

Further Mapping and Characterization of Naq1, a Quantitative Trait Locus Responsible for Maternal Inferior Nurturing Ability in RR Mice

Suto

Sekikawa

2004

The Journal of Veterinary Medical Science

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ABSTRACT. Females of the inbred mouse RR strain have a limited ability to nurture their offspring, and frequently the young die during rearing. We previously identified a significant quantitative trait locus (QTL) responsible for the inferior nurturing ability on chromosome 5 (Naq1), on the basis of litter weight of six pups at days 7, 12, and 21 after parturition. Here, we carried out further mapping of Naq1 to define the confidence interval precisely. At the same time, we analyzed new quantitative trait variables, litter weight gain between days 7 and 12 (WG1), and that between days 12 and 21 (WG2), to characterize further the physiology of inferior nurturing ability . Consequently, a peak LOD score for the Naq1 was identified on D5Mit218 (72 cM), which was located approximately 2 cM distal to our previous expectation, as a significant QTL for WG1 (LOD 5.5), but not for WG2 (LOD 0.9). Because the growth of pups depends purely on milk obtained from the dam up to day 12 after birth, it seems possible to assume that the inferior nurturing ability in RR mice is related to defects in maternal nutritional support (that is, lactation) rather than to defects in pup growth. Naq1 is a novel QTL as far as the QTL results of relevant female reproductive traits in cattle and pigs are concerned. KEY WORDS: inferior nurturing ability, quantitative trait locus (QTL), RR mouse.

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Fine mapping a quantitative trait locus affecting ovulation rate in swine on chromosome 81

Cited by 47 publications

References 34 publications

QTL and candidate genes for fecundity in sows

QTL and candidate genes for fecundity in sows

Detection of quantitative trait loci for teat number and female reproductive traits in Meishan × Large White F2 pigs

Further Mapping and Characterization of Naq1, a Quantitative Trait Locus Responsible for Maternal Inferior Nurturing Ability in RR Mice

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