Financial Burden of Recurrent Urinary Tract Infections in Women: A Time-driven Activity-based Cost Analysis

Gaitonde, Shivani; Malik, Rena D.

doi:10.1016/j.urology.2019.01.031

Cited by 45 publications

(51 citation statements)

References 16 publications

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“…These results were consistent with previous published studies, which have found there was approximately 30-44% of females would have a recurrent UTIs within six months of an initial infection (12,13). Obviously, recurrent UTIs incur a huge economic burden each year due to prevention and treatment (14). The high incidence and recurrence rate of females may relate to many factors, such as physiological structure of the female urinary tract, changes in the acidic environment of the vagina caused by age-related decline in estrogen levels, genetic factors and pregnancy status (15).…”

Section: Dalys Of Urinary Tract Infectionssupporting

confidence: 93%

Epidemiological Trends of Urinary Tract Infections at the Global, Regional, and National Levels from 1990-2017: A Population-Based Study

Zhu

Huang

Luo

et al. 2021

Preprint

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BackgroundUrinary tract infections (UTIs) are some of the most common infections worldwide and consume a lot of medical resources every year. However, there were a lack of available data on its incidence and disease burden. We armed to investigate incidence, mortality, and disability adjusted life-years (DALYs) of urinary tract infections (UTIs) from 1990 to 2017.MethodsWe extracted data from the Global Burden of Disease Study 2017, then calculated estimated annual percentage changes (EAPC) of age-standardized incidence rate (ASIR), age-standardized death rate (ASDR), and age-standardized DALYs rate at global, national, regional, and socio-demographic index (SDI) level.ResultsFrom 1990 to 2017, the globally incident cases (+52.09%), death cases (+140.10%), and DALYs (+69.65%) of UTIs all increased. The ASIR, ASDR, and age-standardized DALYs rate showed upward trends with the EAPC of +0.10 (95%CI: 0.07 to 0.12), +0.72 (95%CI: 0.65-0.78), and +0.06 (95%CI: -0.05 to 0.16), respectively. The ASIR decreased only in the high-middle SDI quantile (-0.26, 95%CI: -0.3 to -0.23). United Arab Emirates had the largest increase of DALYs (+835.04%), but Bulgaria had the largest decrease (-80.74%). EAPC for incidence and mortality were below 0 mainly in Europe and East Asia. In 2017, the incident cases (+3.44 times), the deaths (+1.31 times), and DALYs (+1.21 times) were all higher in females than males. The incident cases were mainly concentrated in 15-49 years old; DALYs and mortality were higher in over 80 age groups.ConclusionsGlobally, the burden of UTIs increased from 1990 to 2017, especially in females; however, distinct varies were observed in different regions and countries. The infants and elders are easier to die when they suffer from UTIs.

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Section: Dalys Of Urinary Tract Infectionssupporting

confidence: 93%

Epidemiological Trends of Urinary Tract Infections at the Global, Regional, and National Levels from 1990-2017: A Population-Based Study

Zhu

Huang

Luo

et al. 2021

Preprint

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“…Oligosaccharides are only one class of numerous cranberry constituents that may affect both host systems and the human microbiome, resulting in diverse and compounded effects on overall health. Product cost must also be considered as a significant factor for products that are to be regularly consumed by patients over long term administration periods [324]. Materials such as WBP, CHEP, CJS, CJS-derived juices, and other conventional food products ( Figure 5), with reduced refinement costs, may therefore be the most appropriate administration forms until more is understood about the various mechanisms by which different cranberry components work together to influence overall health.…”

Section: A New Paradigm For Uti Prevention With Cranberry Materialsmentioning

confidence: 99%

Oligosaccharides and Complex Carbohydrates: A New Paradigm for Cranberry Bioactivity

Coleman

Ferreira

2020

Molecules

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Cranberry is a well-known functional food, but the compounds directly responsible for many of its reported health benefits remain unidentified. Complex carbohydrates, specifically xyloglucan and pectic oligosaccharides, are the newest recognized class of biologically active compounds identified in cranberry materials. Cranberry oligosaccharides have shown similar biological properties as other dietary oligosaccharides, including effects on bacterial adhesion, biofilm formation, and microbial growth. Immunomodulatory and anti-inflammatory activity has also been observed. Oligosaccharides may therefore be significant contributors to many of the health benefits associated with cranberry products. Soluble oligosaccharides are present at relatively high concentrations (~20% w/w or greater) in many cranberry materials, and yet their possible contributions to biological activity have remained unrecognized. This is partly due to the inherent difficulty of detecting these compounds without intentionally seeking them. Inconsistencies in product descriptions and terminology have led to additional confusion regarding cranberry product composition and the possible presence of oligosaccharides. This review will present our current understanding of cranberry oligosaccharides and will discuss their occurrence, structures, ADME, biological properties, and possible prebiotic effects for both gut and urinary tract microbiota. Our hope is that future investigators will consider these compounds as possible significant contributors to the observed biological effects of cranberry.

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“…Although the estimated mortality rate is generally low but it may rise 25%-30% if complicated with bacteremia or septic shock [2,[31][32][33][34]. Gaitonde et.al, 2019 estimated that cost of acute RUTI workup ranged from $390 to $730 [35]. Urinary tract infections are a common reason for healthcare visits.…”

Section: Mini Reviewmentioning

confidence: 99%

Alternative Management of Uncomplicated UTIs in Women

Mohiuddin

2019

JGWH

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UTIs typically cause women to have a severe urge to urinate, and to do so frequently. It's also often very painful when they do, and many experiences a burning sensation in their bladder or urethra. Two common factors emerged in urine that had a better ability to resist bacterial growth: it had a high pH-one that's more alkaline, in other words-and higher levels of certain metabolites formed by gut microbes. Physicians already know how to raise urinary pH with things like calcium supplements, and alkalizing agents are already used in the U.K. as over-the-counter UTI treatments. However, early on in an infection, cells produce a protein called siderocalin that blocks bacterial growth, including the growth of E. coli. Uncomplicated UTIs usually go away with drugs within two to three weeks, but in some cases, women may take antibiotics for 6 months or longer if their UTIs keep coming back. Most UTIs are caused by the bacteria Escherichia coli (E. coli), and recent surveillance data shows a significant rise in cases of UTIs caused by E. coli that are resistant to the antibiotics most commonly used to that treat them. Doctors say "It's uncomfortable but not life-threatening, so women don't go in" [1].

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Financial Burden of Recurrent Urinary Tract Infections in Women: A Time-driven Activity-based Cost Analysis

Cited by 45 publications

References 16 publications

Epidemiological Trends of Urinary Tract Infections at the Global, Regional, and National Levels from 1990-2017: A Population-Based Study

Epidemiological Trends of Urinary Tract Infections at the Global, Regional, and National Levels from 1990-2017: A Population-Based Study

Oligosaccharides and Complex Carbohydrates: A New Paradigm for Cranberry Bioactivity

Alternative Management of Uncomplicated UTIs in Women

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