Final Report of the Cosmetic Ingredient Review Expert Panel Safety Assessment of Polymethyl Methacrylate (PMMA), Methyl Methacrylate Crosspolymer, and Methyl Methacrylate/Glycol Dimethacrylate Crosspolymer

Abstract

Polymethyl methacrylate (PMMA) and related cosmetic ingredients methyl methacrylate crosspolymer and methyl methacrylate/glycol dimethacrylate crosspolymer are polymers that function as film formers and viscosity-increasing agents in cosmetics. The Food and Drug Administration (FDA) determination of safety of PMMA use in several medical devices, which included human and animal safety data, was used as the basis of safety of PMMA and related polymers in cosmetics by the Cosmetic Ingredient Review (CIR) Expert Panel. The PMMA used in cosmetics is substantially the same as in medical devices. The Panel concluded that these ingredients are safe as cosmetic ingredients in the practices of use and concentrations as described in this safety assessment.

Biodegradable and Petroleum-Based Microplastics Do Not Differ in Their Ingestion and Excretion but in Their Biological Effects in a Freshwater Invertebrate Gammarus fossarum

“…At least 75 different genera of microorganisms are able to produce PHB, and more than 100 different monomer units have been identified so far [ 17 ]. Polymethylmethacrylate is the polymer of methyl methacrylate (MMA); it is widely used and also known as acrylic glass [ 18 ]. Recent reviews have highlighted the contribution of personal care products to microplastic pollution in the environment [ 19 ].…”

Method Validation for Progesterone Determination in Poly(methyl methacrylate) Nanoparticles Synthesized via Miniemulsion Polymerization

“…PMMA is considered safe for applications in various biomedical products as intraocular lenses, bone cement, and dental material, and it is registered in several cosmetic products [27]. Toxicological studies with the use of PMMA nanoparticles with satisfactory results were obtained by Lekshmi et al [28] when evaluating in vivo toxicity in albino rats.…”

Use of Polymethyl Methacrylate-Based Cement for Cosmetic Correction of Donor-Site Defect following Transposition of Temporalis Myofascial Flap and Evaluation of Results after Adjuvant Radiotherapy

“…The short-and long-term results of the use of these implants are highly satisfactory, and their use is also approved by the Cosmetic Ingredient Review Expert Panel. [11][12][13][14] Some authors have advocated for the use of a buccal fat flap, bony graft, or other autologous material for deformity correction. The issue with these materials is that they tend to become reabsorbed in the long-term or after radiation, resulting in poor cosmetic results at long-term follow-up.…”