Final design of the C-SPECT-I lab-prototype

Chang, Wei; Rozler, Michael; Poopalasingam, Sankar; Stentz, D.; Strologas, J.; Arseneau, Roger; Metzler, S.

doi:10.1109/nssmic.2015.7582131

Cited by 5 publications

(3 citation statements)

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“…An initial laboratory prototype consisting of three modules has been constructed [6]. The prototype was mounted on a preliminary gantry and conveyer; the slit interchange system as well as the slat collapsing hydraulics were tested successfully.…”

Section: First Laboratory Prototype Resultsmentioning

confidence: 99%

“…After the successful construction of the initial laboratory prototype, we are in the process of assembling the full 14-module pre-clinical system [6]. This next stage will allow us to study the full functionality and performance of the designed system in SPECT and CT modes, including its DAQ behavior and fast real-time reconstruction capabilities.…”

Section: Current Status and Conclusionmentioning

confidence: 99%

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C-SPECT, a novel cardiac single-photon emission computed tomography system

Strologas¹,

Rozler²,

Metzler³

et al. 2017

Proceedings of 38th International Conference on High Energy Physics — PoS(ICHEP2016)

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Single-photon emission computed tomography (SPECT) is the leading medical-imaging method for the study myocardial perfusion, which is important for the diagnosis and treatment of coronary-artery disease, the number-one killer in the western world. C-SPECT is a proposed dedicated cardiac SPECT system designed to achieve at least double the geometric efficiency compared to general-purpose dual-head gamma cameras, for the same resolution. This improvement can be used to reduce patient radiation dose, achieve fast or dynamic imaging, and enhance the quality of images. The system consists of stationary detector modules of pixelated NaI(Tl), a slit-slat collimator with interchangeable slits and collapsible slats, and an integrated CT for attenuation correction. The collimator slits provide pinhole collimation in the transverse plane, whereas the slats offer parallel-beam collimation in the axial direction. The adaptive power of the collimator allows us to adjust, in situ, the sensitivity and resolution depending on the imaging task. This way, superior reconstructed-image resolution could be achieved if the system operates with the usual geometric efficiency of the industry's benchmark. The system gantry wraps around patients' left-front thorax and provides a transverse projection minification of ∼ 50%, for a maximal number of minimally-overlapping projections, given the limitations from the spatial resolution of the pixelated detector. We present the design principles and preliminary imaging performance using three-dimensional iterative reconstruction with resolution recovery and data from the newly-built laboratory prototype as well as Monte-Carlo (MC) simulations of the full system.

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Section: First Laboratory Prototype Resultsmentioning

confidence: 99%

Section: Current Status and Conclusionmentioning

confidence: 99%

C-SPECT, a novel cardiac single-photon emission computed tomography system

Strologas¹,

Rozler²,

Metzler³

et al. 2017

Proceedings of 38th International Conference on High Energy Physics — PoS(ICHEP2016)

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show abstract

“…The major concept of this platform was to design a C-shaped stationary detector gantry wrapping around the heart with the ability of performing both high-quality emission and transmission scans, as shown in figure 6(f). Based on this platform, a lab-prototype system was developed using slit-slat collimators, achieving a 2.5 times higher sensitivity and comparable resolution as a conventional dual-head SPECT system with parallel-hole collimator (Chang et al 2015).…”

Section: Emerging Cardiac Spect Collimators and Systems Under Researc...mentioning

confidence: 99%

Recent advances in cardiac SPECT instrumentation and imaging methods

Liu

2019

Phys. Med. Biol.

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Cardiac SPECT continues to play a critical role in detecting and managing cardiovascular disease, in particularly coronary artery disease (CAD) (Jaarsma et al 2012 J. Am. Coll. Cardiol. 59 1719–28), (Agostini et al 2016 Eur. J. Nucl. Med. Mol. Imaging 43 2423–32). While conventional dual-head SPECT scanners using parallel-hole collimators and scintillation crystals with photomultiplier tubes are still the workhorse of cardiac SPECT, they have the limitations of low photon sensitivity (~130 count s−1 MBq−1), poor image resolution (~15 mm) (Imbert et al 2012 J. Nucl. Med. 53 1897–903), relatively long acquisition time, inefficient use of the detector, high radiation dose, etc. Recently our field observed an exciting growth of new developments of dedicated cardiac scanners and collimators, as well as novel imaging algorithms for quantitative cardiac SPECT. These developments have opened doors to new applications with potential clinical impact, including ultra-low-dose imaging, absolute quantification of myocardial blood flow (MBF) and coronary flow reserve (CFR), multi-radionuclide imaging, and improved image quality as a result of attenuation, scatter, motion, and partial volume corrections (PVCs). In this article, we review the recent advances in cardiac SPECT instrumentation and imaging methods. This review mainly focuses on the most recent developments published since 2012 and points to the future of cardiac SPECT from an imaging physics perspective.

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