There are 148,311 people with Diabetes Mellitus in South Sulawesi, and 34,564 (23.30%) of them are patients who receive standard services, domiciled in Makassar City. This study aims to determine the social determinants of urban public health with the incidence of diabetes mellitus.The research method is qualitative, the type of research is a case study of five families in Makassar City. The results of the study indicate that aspects of knowledge, social environment, and institutions are the determinants of DM cases in urban communities. This aspect is determined by unhealthy social behavior based on genetic factors, age, and lifestyle. The better the knowledge, environment, and institutions that are owned, will form healthy social behavior in dealing with DM sufferers