Film coatings for oral colon delivery

“Colon Targeted Delivery System (Codestm): Propitious Approach in Targeting Colon”

“…The system comprises of a polysaccharide in the tablet core acting as a triggering agent for site specific release of drug in the colon. The system is first coated with acid soluble polymer [11] , followed with or without a barrier layer [12] and final coating of enteric polymer which releases the drug at targeted site i.e. colon.…”

Development of Eudragit® S100 based pH-responsive microspheres of zaleplon by spray-drying: Tailoring the drug release properties

“…E NE30D is insoluble polymer with low permeability which is often used in development of different formulation with time-controlled, pHindependent drug release [25][26][27][28]. It poses excellent film forming properties and it can be used for the preparation of different matrix-type drug delivery systems [29]. During the preparation of the spray-drying feed, E NE30D was added into the alkaline E S100 , prior the addition of the ethanolic solution of ZAL.…”

Introduction

“…Polysaccharidegel-based colon cancer therapy was studied recently using 5-fluorouracil in CHT micro- [107] and nanospheres [102] or paclitaxel in chitin nanoparticles [132]. Protein delivery from polysaccharide gels was also studied: BSA, used as a model, was investigated by Zeng et al [162], Cwp84-loaded pectin beads were tested for oral vaccination against Clostridium difficile [118], while a review reporting some examples of the use of polysaccharide gels for insulin oral admistration was recently published by Maroni et al [82]. Numerous studies on delivery of probiotic bacteria by means of their entrapment in polysaccharide gels were also carried out [20].…”