“Colon Targeted Delivery System (Codestm): Propitious Approach in Targeting Colon”

Trivedi, Hemangi Deepak

doi:10.20959/wjpps20174-8951

Cited by 6 publications

(2 citation statements)

References 22 publications

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“…Different strategies like pro-drug, enteric coating and pH/time-dependent modified release, microfloraactivated system, pressure controlled drug delivery system (PCDCS), osmotic controlled drug delivery to colon (OROS-CT), and pulsatile drug delivery have gained attention. 7 Based upon these strategies, the different products of 5-aminosalicylic acid (5-ASA) available are Pentasa ® MR coated timed release microgranules, Asacol ® and Aspiro ® CR double layered enteric coated tablets, Lialda ® XL Multimatrix SR hydrophilic/lipophilic matrix core tablets, Octasa ® MR pH sensitive coated tablets and Salofalk ® gastric-resistant granules coated by pHindependent polymer. [8][9][10][11][12][13] But their polymer-dependent behavior and predicted drug release in the colon remained debatable.…”

Section: Introductionmentioning

confidence: 99%

<p>Artificial Neural Network (ANN) Approach to Predict an Optimized pH-Dependent Mesalamine Matrix Tablet</p>

Khan

Hanif

Bukhari

et al. 2020

DDDT

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Point your SmartPhone at the code above. If you have a QR code reader the video abstract will appear. Or use: https://youtu.be/AP32Kh16ZpUBackground: Severe bleeding and perforation of the colon and rectum are complications of ulcerative colitis which can be treated by a targeted drug delivery system.Purpose: Development of colon-targeted delivery usually involves a complex formulation process and coating steps of pH-sensitive methacrylic acid based Eudragit ® . The current work was purposefully designed to develop dicalcium phosphate (DCP) facilitated with Eudragit-S100-based pH-dependent, uncoated mesalamine matrix tablets. Materials and Methods: Mesalamine formulations were compressed using wet granulation technique with varying compositions of dicalcium phosphate (DCP) and Eudragit-S100. The developed formulations were characterized for physicochemical and drug release profiles.Infrared studies were carried out to ensure that there was no interaction between active ingredients and excipients. Artificial neural network (ANN) was used for the optimization of final DCP-Eudragit-S100 complex and the experimental data were employed to train a multilayer perception (MLP) using quick propagation (QP) training algorithm until a satisfactory root mean square error (RMSE) was reached. The ANN-aided optimized formulation was compared with commercially available Masacol ® .Results: Compressed tablets met the desirability criteria in terms of thickness, hardness, weight variation, friability, and content uniformity, ie, 5.34 mm, 7.7 kg/cm 2, 585±5 mg (%), 0.44%, and 103%, respectively. In-vitro dissolution study of commercially available mesalamine and optimized formulation was carried out and the former showed 100% release at 6 h while the latter released only 12.09% after 2 h and 72.96% after 12 h which was fitted to Weibull release model with b value of 1.3, indicating a complex release mechanism. Conclusion: DCP-Eudragit-S100 blend was found explicative for mesalamine release without coating in gastric and colonic regions. This combination may provide a better control of ulcerative colitis.

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Section: Introductionmentioning

confidence: 99%

<p>Artificial Neural Network (ANN) Approach to Predict an Optimized pH-Dependent Mesalamine Matrix Tablet</p>

Khan

Hanif

Bukhari

et al. 2020

DDDT

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“…the stomach and small intestine. This means that the colon specific formulation should resist the gastric and intestinal pH and dissolve at pH 7 in the colon 8 . Colonic microflora is another factor that affects colon targeted drug delivery.…”

Section: Issn 2321-547xmentioning

confidence: 99%

Preparation and In vitro Evaluation of Enteric Coated Oral Vancomycin Hydrochloride Sustained Release Formulation with Mucoadhesive Properties

Alsharkas¹,

Kumar²,

Yeong³

2018

Am J Drug Deliv

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Clostridium difficile is a species of gram-positive bacteria thought to infect patients with weakened immune response resulting in colitis. Oral vancomycin hydrochloride is given four times a day to treat Clostridium difficile colitis and is commercially available in the form of capsule and solution. Patient's compliance is the main issue in this treatment due to the multiple dosing frequencies. Accordingly, replacement of such dose regimen with a once daily dosage will enhance patient compliance. In this study, mucoadhesive vancomycin hydrochloride tablets were prepared with the use of chitosan to exert a local effect in the colon. Sustained release property was also imparted by chitosan. Enteric coating with Eudragit ® S 100 was applied to prevent the sticking of chitosan tablets in the stomach and small intestine and deliver the tablets intact to the colon. The prepared tablets were evaluated for In vitro drug release for 24 hours and compared with the marketed formulation. The formulation was found to release in a sustained manner in pH 7.4 buffer allowing the colon delivered oral vancomycin hydrochloride to be a promising formulation in the development of a once daily treatment for Clostridium difficile colitis.

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Applications of Polymers in Colon Drug Delivery

Bardoliwala

Baradia

Amrutiya

et al. 2021

Applications of Polymers in Drug Delivery

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“Colon Targeted Delivery System (Codestm): Propitious Approach in Targeting Colon”

Abstract: Over the last few decades, colon targeted systems have gained interest to overcome the problems of specific delivery of the active

Cited by 6 publications

References 22 publications

<p>Artificial Neural Network (ANN) Approach to Predict an Optimized pH-Dependent Mesalamine Matrix Tablet</p>

<p>Artificial Neural Network (ANN) Approach to Predict an Optimized pH-Dependent Mesalamine Matrix Tablet</p>

Preparation and In vitro Evaluation of Enteric Coated Oral Vancomycin Hydrochloride Sustained Release Formulation with Mucoadhesive Properties

Applications of Polymers in Colon Drug Delivery

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