Filament-anchored hydrogel layer on polypropylene hernia mesh with robust anti-inflammatory effects

Qiao, Yansha; Zhang, Qian; Wang, Qian; Li, Yan

doi:10.1016/j.actbio.2021.04.013

Cited by 18 publications

(9 citation statements)

References 62 publications

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“…However, the mechanical characteristics of hydrogels were substantially influenced by the concentration of TA cross-linker and the treatment period (dipping time). 103 By utilizing TA as the non-covalent cross-linker, the resulting PEG–lysozyme (LZM)–TA hydrogel presented super toughness and high elasticity compared to the pristine PEG–LZM hydrogel (Fig. 6c).…”

Section: Ta-tethered Functional Materialsmentioning

confidence: 99%

Recent progress in tannic acid-driven antibacterial/antifouling surface coating strategies

et al. 2022

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Section: Ta-tethered Functional Materialsmentioning

confidence: 99%

Recent progress in tannic acid-driven antibacterial/antifouling surface coating strategies

et al. 2022

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“…In and in vivo experiment, the FBGC amount on the hydrogel-coated mesh was reduced by 95% in comparison to the original mesh at week 2, the effect lasted for 12 weeks, and the fibrous capsule was also noticeably reduced. Qiao et al 105 constructed a filament-anchored hydrogel layer (FAHL) on PP mesh (FAHL-P) without affecting the function of the PP mesh. The raw materials for the FAHL are chondroitin sulfate and gelatin (CG) extracted from natural ECM.…”

Section: Strategies For Reducing Postoperative Complicationsmentioning

confidence: 99%

Latest Trends on the Attenuation of Systemic Foreign Body Response and Infectious Complications of Synthetic Hernia Meshes

Fang

Wang

et al. 2021

ACS Appl. Bio Mater.

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Throughout the past few years, hernia incidence has remained at a high level worldwide, with more than 20 million people requiring hernia surgery each year. Synthetic hernia meshes play an important role, providing a microenvironment that attracts and harbors host cells and acting as a permanent roadmap for intact abdominal wall reconstruction. Nevertheless, it is still inevitable to cause not-so-trivial complications, especially chronic pain and adhesion. In long-term studies, it was found that the complications are mainly caused by excessive fibrosis from the foreign body reaction (FBR) and infection resulting from bacterial colonization. For a thorough understanding of their complex mechanism and providing a richer background for mesh development, herein, we discuss different clinical mesh products and explore the interactions between their structure and complications. We further explored progress in reducing mesh complications to provide varied strategies that are informative and instructive for mesh modification in different research directions. We hope that this work will spur hernia mesh designers to step up their efforts to develop more practical and accessible meshes by improving the physical structure and chemical properties of meshes to combat the increasing risk of adhesions, infections, and inflammatory reactions. We conclude that further work is needed to solve this pressing problem, especially in the analysis and functionalization of mesh materials, provided of course that the initial performance of the mesh is guaranteed.

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“…Pectin/polyacrylamide hydrogels successfully deliver budesonide to the colon (99). Tannic acid acts as a cross linker and additionally enhances the antiinflammatory properties of hydrogels (100). Topical hydrogels containing Achyrocline satureioides oily extract can reduce inflammation (101).…”

Section: Improvement In Radiotherapy A) Shieldingmentioning

confidence: 99%

Radiotherapy-Induced Digestive Injury: Diagnosis, Treatment and Mechanisms

et al. 2021

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Radiotherapy is one of the main therapeutic methods for treating cancer. The digestive system consists of the gastrointestinal tract and the accessory organs of digestion (the tongue, salivary glands, pancreas, liver and gallbladder). The digestive system is easily impaired during radiotherapy, especially in thoracic and abdominal radiotherapy. In this review, we introduce the physical classification, basic pathogenesis, clinical characteristics, predictive/diagnostic factors, and possible treatment targets of radiotherapy-induced digestive injury. Radiotherapy-induced digestive injury complies with the dose-volume effect and has a radiation-based organ correlation. Computed tomography (CT), MRI (magnetic resonance imaging), ultrasound (US) and endoscopy can help diagnose and evaluate the radiation-induced lesion level. The latest treatment approaches include improvement in radiotherapy (such as shielding, hydrogel spacers and dose distribution), stem cell transplantation and drug administration. Gut microbiota modulation may become a novel approach to relieving radiogenic gastrointestinal syndrome. Finally, we summarized the possible mechanisms involved in treatment, but they remain varied. Radionuclide-labeled targeting molecules (RLTMs) are promising for more precise radiotherapy. These advances contribute to our understanding of the assessment and treatment of radiation-induced digestive injury.

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Filament-anchored hydrogel layer on polypropylene hernia mesh with robust anti-inflammatory effects

Cited by 18 publications

References 62 publications

Recent progress in tannic acid-driven antibacterial/antifouling surface coating strategies

Recent progress in tannic acid-driven antibacterial/antifouling surface coating strategies

Latest Trends on the Attenuation of Systemic Foreign Body Response and Infectious Complications of Synthetic Hernia Meshes

Radiotherapy-Induced Digestive Injury: Diagnosis, Treatment and Mechanisms

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