Fighting S. aureus catheter-related infections with sophorolipids: Electing an antiadhesive strategy or a release one?

Recent nanotechnology-based strategies for interfering with the life cycle of bacterial biofilms

“…Rita M. Mendes et al compared the antimicrobial activity of sophorolipid-releasing surfaces with the contact-killing strategy using sophorolipid-tethered surfaces. 83 The results turned out that the releasing strategy achieved a better inhibitory effect on biofilm formation, which might be attributed to the bactericidal effect in a wider range of microenvironments by releasing antimicrobials rather than the local bactericidal effect that only kills the adhered cells on the surfaces.…”

“…Rita M. Mendes et al compared the antimicrobial activity of sophorolipid-releasing surfaces with the contact-killing strategy using sophorolipid-tethered surfaces. 83 The results turned out that the releasing strategy achieved a better inhibitory effect on biofilm formation, which might be attributed to the bactericidal effect in a wider range of microenvironments by releasing antimicrobials rather than the local bactericidal effect that only kills the adhered cells on the surfaces. Some antimicrobial metal ions (e.g., Cu 2+ 84 and Ag + 85 ) and ion-leaching metal nanoparticles (e.g., silver nanoparticles (AgNPs), 86 metal-organic framework (MOF) nanoparticles 87 ) are easily decorated on biomaterial surfaces and thus usually utilized to fabricate antimicrobial agent releasing surfaces.…”

Bonding antimicrobial rhamnolipids onto medical grade PDMS: A strategy to overcome multispecies vascular catheter-related infections

“…Chemical etching aimed a long-lasting modification starting with the oxidation of the surface using "piranha solution" pointed as a compatible, low-cost and robust procedure [23]. The oxidation of the surface enables the process of silanization, that is the covering of the surface with an organofunctional alkoxysilane molecule (3-aminopropyltriethoxysilane, APTES) [24,25], owning active functional groups to the PDMS surface such as amine. The amine anchoring groups promoted the binding of rhamnolipids (RLs), natural glycolipid biosurfactant compounds with antibacterial and antifungal properties [25][26][27][28].…”

Drug Delivery from PCL/Chitosan Multilayer Coatings for Metallic Implants

“… 7 New approaches have been sought after, in the form of antimicrobial surfaces, that can be divided into structured surfaces, permanent antimicrobial surfaces, and elution systems. 8 , 9 Structures such as nanoparticle- and nanotube-modified surfaces, 10 , 11 and engineered metal topographies such as alterations in charge, hydrophobicity, roughness, and porosity 9 , 12 , 13 have been studied. Permanent antimicrobial surfaces, that contain permanently bonded agents that generate antimicrobial surfaces and prevent long-term bacterial adhesion 14 , 15 have also been created.…”

“…Furthermore, antibiotic therapy is long-lasting, and to achieve effective therapeutic drug concentration at the site of infection, a high parenteral dose of antibiotic is needed, which can lead to systemic toxicity . New approaches have been sought after, in the form of antimicrobial surfaces, that can be divided into structured surfaces, permanent antimicrobial surfaces, and elution systems. , Structures such as nanoparticle- and nanotube-modified surfaces, , and engineered metal topographies such as alterations in charge, hydrophobicity, roughness, and porosity ,, have been studied. Permanent antimicrobial surfaces, that contain permanently bonded agents that generate antimicrobial surfaces and prevent long-term bacterial adhesion , have also been created. − To further improve the antimicrobial effect of implants, studies veered into the usage of drugs in their composition, via the creation of elution systems, that actively release antimicrobials to inhibit bacterial adhesion and/or promote bacterial cell death in both the implant and adjacent tissues .…”