Fifty Years of Nucleic Acid Electrochemistry

Paleček, Emil

doi:10.1002/elan.200804416

Cited by 90 publications

(54 citation statements)

References 154 publications

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“…The ability of DNA and RNA to undergo reduction and oxidation processes at mercury electrodes was discovered more than 50 years ago [1,2]. Soon it was found that the electrochemical signals are strongly influenced by the DNA structure [1,3,4].…”

Section: Introductionmentioning

confidence: 99%

Square Wave Stripping Voltammetry of Unlabeled Single‐ and Double‐Stranded DNAs

Bartošík

Paleček

2011

Electroanalysis

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We show that, in difference to previously applied electrochemical methods working with stationary electrodes, square wave voltammetry produces well-developed peaks II SW (specific for dsDNA) and III SW yielded by ssDNA at hanging mercury drop electrode (HMDE) and solid amalgam electrodes (SAEs). Using these peaks various kinds of DNA structural transitions can be studied, including unwinding of dsDNA at negatively charged electrode surfaces. The sensitivity of the DNA analysis is much better than that obtained with guanine oxidation signals at carbon electrodes. Both carbon electrodes and SAEs appear attractive as transducers in label-free RNA and DNA sensors.

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Section: Introductionmentioning

confidence: 99%

Square Wave Stripping Voltammetry of Unlabeled Single‐ and Double‐Stranded DNAs

Bartošík

Paleček

2011

Electroanalysis

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“…Electrochemical nucleic acid biosensors have received considerable attention for the detection of biological agents due to their ability to obtain sequence-specific information in a rapid, sensitive, low cost, reproducible and portable manner [7][8][9]. Electrochemical hybridization biosensors are also characterized by their minimal power requirements and independent of sample turbidity.…”

Section: Electrochemical Nucleic Acid Biosensors Formentioning

confidence: 99%

Ternary Monolayer Interfaces for Ultrasensitive and Direct Bioelectronic Detection of Nucleic Acids in Complex Matrices

2011

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Electrochemical nucleic acid biosensors have received considerable attention for the detection of biological agents. Control of the surface chemistry and coverage of the electrode transducer are essential for enhancing the performance of electrochemical DNA biosensors, and particularly for maximizing the hybridization efficiency and minimizing of nonspecific adsorption events. This review highlights recent advances and progress in the development of new surface chemistry approaches based on novel ternary DNA self-assembled monolayer (SAM)-interfaces using dithiols as new co-adsorbents/backfillers. The design and characterization of these powerful ternary SAM interfaces on different gold transducers are described, along with their implications to electrochemical biosensing of bioagents.

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“…42,99 In this case, a signal change could be detected directly without necessity of electroactive labels. In the text, we describe only pioneering, interesting, or outstanding articles.…”

Section: Nucleic Acid Electrochemical Biosensorsmentioning

confidence: 99%

Nanoscale virus biosensors: state of the art

Krejčová¹,

Michálek²,

Rodrigo³

et al. 2015

NDD

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Abstract:Since the beginning of the new millennium, viruses have shown huge epidemiological and pandemic potential: severe acute respiratory syndrome (SARS) in 2002, pandemic swine flu in 2009, and last but not least the West African Ebola outbreak in 2014. The occurrence and spread of the new virus in pandemic dimension poses a threat to the health and lives of 7 billion people worldwide. There is a growing urgency for highly sensitive and selective detection techniques, usable for a wide number of applications, including disease diagnosis, pharmaceutical research, agriculture, as well as preventive measures. Nanobiosensors represent a new promising tool for virus detection. This review gives a brief survey of the issue of viral detection, comprising diagnostics of target structure of viruses such as nucleic acids or proteins. This review covers different detection principles, methods of fabrication, and applications of virus biosensors.

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Fifty Years of Nucleic Acid Electrochemistry

Cited by 90 publications

References 154 publications

Square Wave Stripping Voltammetry of Unlabeled Single‐ and Double‐Stranded DNAs

Square Wave Stripping Voltammetry of Unlabeled Single‐ and Double‐Stranded DNAs

Ternary Monolayer Interfaces for Ultrasensitive and Direct Bioelectronic Detection of Nucleic Acids in Complex Matrices

Nanoscale virus biosensors: state of the art

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