Fifty‐one full‐length major histocompatibility complex class II alleles in the olive baboon (<i>Papio anubis</i>)

Otting, Nel; Wiel, Marit K. H. van der; Doxiadis, Gaby G. M.; Bontrop, Ronald E.

doi:10.1111/tan.12906

Cited by 3 publications

(5 citation statements)

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“…The alleles of the DQA1*01 lineage combine exclusively with DQB1*06 alleles, a combination that is also observed in humans, macaques, and olive baboons (Fig. 4) (Otting et al 2016(Otting et al , 2017. The DQA1*01/DQB1*06 pairing predates the separation of hominoids and Old World monkeys and confirms the trans-species model of evolution (Doxiadis et al 2001;Klein 1987).…”

Section: The Patr-dq and -Dp Tandemssupporting

confidence: 73%

“…2). Members of the DQA1*01 and *05 lineages are also present in the olive baboon (Papio anubis) that lives in equatorial Africa, and in various macaque species that have their habitat all over Asia (Otting et al 2016(Otting et al , 2017. As a representative sample for the macaque species, the data of the longtailed macaque (Macaca fascicularis) is included in Fig.…”

Section: Patr-dqa and -Dqb Allelesmentioning

confidence: 99%

“…The rapid evolution has hampered the division of HLA-DPB alleles into distinct lineages, and as a consequence, each allele has received its own lineage number, up to 702 at the moment. This is in contrast to the situation in Old World monkeys, in which the DPB alleles show a clear division into lineages (Otting et al 2016(Otting et al , 2017. Thus far, for the Patr-DPB exon 2 alleles that were archived in the databases, the same nomenclature rule was used as for HLA-DPB alleles, and each allele received its own lineage number.…”

Section: Patr-dpa and -Dpb Allelesmentioning

confidence: 99%

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Limited MHC class II gene polymorphism in the West African chimpanzee is distributed maximally by haplotype diversity

2018

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Chimpanzees have been used for some time as an animal model in research on immune-related diseases in humans. The major histocompatibility complex (MHC) region of the chimpanzee has also been the subject of studies in which the attention was mainly on the class I genes. Although full-length sequence information is available on the DRB region genes, such detailed information is lacking for the other class II genes and, if present, is based mainly on exon 2 sequences. In the present study, full-length sequencing was performed on DQ, DP, and DRA genes in a cohort of 67 pedigreed animals, thereby allowing a thorough analysis of the MHC class II repertoire. The results demonstrate that the number of MHC class II lineages and alleles is relatively low, whereas haplotype diversity (combination of genes/alleles on a chromosome) seems to have been maximised by crossing-over processes.

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Section: The Patr-dq and -Dp Tandemssupporting

confidence: 73%

Section: Patr-dqa and -Dqb Allelesmentioning

confidence: 99%

Section: Patr-dpa and -Dpb Allelesmentioning

confidence: 99%

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Limited MHC class II gene polymorphism in the West African chimpanzee is distributed maximally by haplotype diversity

2018

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“…As found in macaques, the DRB region ( Paan-DRB ) in the olive baboon shows a high level of region configuration polymorphism, whereas allelic variation appears to be absent (de Groot et al 2017a ). Furthermore, the Paan - DQ , Paan - DP , and Paan - DRA genes have been analysed by full-length cDNA sequencing, demonstrating substantial levels of allelic heterogeneity (Otting et al 2016 ).…”

Section: Introductionmentioning

confidence: 99%

MHC class I diversity of olive baboons (Papio anubis) unravelled by next-generation sequencing

et al. 2018

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The olive baboon represents an important model system to study various aspects of human biology and health, including the origin and diversity of the major histocompatibility complex. After screening of a group of related animals for polymorphisms associated with a well-defined microsatellite marker, subsequent MHC class I typing of a selected population of 24 animals was performed on two distinct next-generation sequencing (NGS) platforms. A substantial number of 21 A and 80 B transcripts were discovered, about half of which had not been previously reported. Per animal, from one to four highly transcribed A alleles (majors) were observed, in addition to ones characterised by low transcripion levels (minors), such as members of the A*14 lineage. Furthermore, in one animal, up to 13 B alleles with differential transcription level profiles may be present. Based on segregation profiles, 16 Paan-AB haplotypes were defined. A haplotype encodes in general one or two major A and three to seven B transcripts, respectively. A further peculiarity is the presence of at least one copy of a B*02 lineage on nearly every haplotype, which indicates that B*02 represents a separate locus with probably a specialistic function. Haplotypes appear to be generated by recombination-like events, and the breakpoints map not only between the A and B regions but also within the B region itself. Therefore, the genetic makeup of the olive baboon MHC class I region appears to have been subject to a similar or even more complex expansion process than the one documented for macaque species.Electronic supplementary materialThe online version of this article (10.1007/s00251-018-1053-7) contains supplementary material, which is available to authorized users.

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“…The Dudley et al 2014;van der Wiel et al 2015;Otting et al 2017), Macaca nemestrina (Karl et al 2014;van der Wiel et al 2015;Otting et al 2017;Semler et al 2018), Macaca thibetana (Yan et al 2013;Min et al 2019), Papio anubis (Otting et al 2016;Morgan et al 2018;van der Wiel et al 2018), Papio hamadryas (Morgan et al 2018, Aotus nancymaae and Aotus vociferans (Lopez et al 2014), Ateles fusciceps (Cao et al 2015), and Callithrix jacchus (van der Wiel et al 2013), and Otting et al and Mueller et al, unpublished) (Table 1, blue numbers in column 2019).…”

Section: Spmentioning

confidence: 99%

Nomenclature report 2019: major histocompatibility complex genes and alleles of Great and Small Ape and Old and New World monkey species

et al. 2019

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The major histocompatibility complex (MHC) is central to the innate and adaptive immune responses of jawed vertebrates. Characteristic of the MHC are high gene density, gene copy number variation, and allelic polymorphism. Because apes and monkeys are the closest living relatives of humans, the MHCs of these non-human primates (NHP) are studied in depth in the context of evolution, biomedicine, and conservation biology. The Immuno Polymorphism Database (IPD)-MHC NHP Database (IPD-MHC NHP), which curates MHC data of great and small apes, as well as Old and New World monkeys, has been upgraded. The curators of the database are responsible for providing official designations for newly discovered alleles. This nomenclature report updates the 2012 report, and summarizes important nomenclature issues and relevant novel features of the IPD-MHC NHP Database. Keywords MHC . NHP . Database . Nomenclature . IPD Natasja G. de Groot and Nel Otting contributed equally to this work. This article is part of the Topical Collection on "Nomenclature, databases and bioinformatics in Immunogenetics" Natasja G. de Groot, Nel Otting, and Ronald E. Bontrop are curators of the IPD-MHC NHP database.

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Fifty‐one full‐length major histocompatibility complex class II alleles in the olive baboon (Papio anubis)

Abstract: Here we report 51 novel major histocompatibility complex (MHC) class II alleles in a group of related olive baboons.

Cited by 3 publications

References 6 publications

Limited MHC class II gene polymorphism in the West African chimpanzee is distributed maximally by haplotype diversity

Limited MHC class II gene polymorphism in the West African chimpanzee is distributed maximally by haplotype diversity

MHC class I diversity of olive baboons (Papio anubis) unravelled by next-generation sequencing

Nomenclature report 2019: major histocompatibility complex genes and alleles of Great and Small Ape and Old and New World monkey species

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