Field vaccinated chickens with low antibody titres show equally insufficient protection against matching and non-matching genotypes of virulent Newcastle disease virus

Dortmans, J. C. F. M.; Venema-Kemper, S.; Peeters, Ben; Koch, G.

doi:10.1016/j.vetmic.2014.05.004

Cited by 19 publications

(7 citation statements)

References 21 publications

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“…Van Boven et al [12] showed that vaccination using two live attenuated vaccines (Ulster, or LaSota) in a prime-boost regime sufficiently reduced transmission (R < 1) when a HI titer higher than 3 log 2 was reached in at least 85% of the vaccinated population. However, this level of protection is hardly ever achieved in broiler chickens under field conditions, possibly due to poor vaccination practices, inadequate vaccination schedules, or maternal antibodies interference, among others [26,27]. Consequently, there is a need for vaccines that could both effectively reduce transmission when applied in chickens with MDA and be easily and consistently mass-administered under field conditions.…”

Section: Discussionmentioning

confidence: 99%

A Herpesvirus of Turkey-Based Vector Vaccine Reduces Transmission of Newcastle Disease Virus in Commercial Broiler Chickens with Maternally Derived Antibodies

Tatár-Kis¹,

Fischer

Cazaban

et al. 2020

Vaccines

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Newcastle Disease is one of the most important infectious poultry diseases worldwide and is associated with high morbidity, mortality, and economic loss. In several countries, vaccination is applied to prevent and control outbreaks; however, information on the ability of vaccines to reduce transmission of ND virus (NDV) is sparse. Here we quantified the transmission of velogenic NDV among 42-day-old broilers. Chickens were either vaccinated with a single dose of a vector vaccine expressing the F protein (rHVT-ND) at day-old in the presence of maternally derived antibodies or kept unvaccinated. Seeders were challenged 8 h before the co-mingling with the corresponding contacts from the same group. Infection was monitored by daily testing of cloacal and oro-nasal swabs with reverse transcription- real-time PCR and by serology. Vaccinated birds were completely protected against clinical disease and virus excretion was significantly reduced compared to the unvaccinated controls that all died during the experiment. The reproduction ratio, which is the average number of secondary infections caused by an infectious bird, was significantly lower in the vaccinated group (0.82 (95%CI 0.38–1.75)) than in the unvaccinated group (3.2 (95% CI 2.06–4.96)). Results of this study demonstrate the potential of rHVT-ND vaccine in prevention and control of ND outbreaks.

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Section: Discussionmentioning

confidence: 99%

A Herpesvirus of Turkey-Based Vector Vaccine Reduces Transmission of Newcastle Disease Virus in Commercial Broiler Chickens with Maternally Derived Antibodies

Tatár-Kis¹,

Fischer

Cazaban

et al. 2020

Vaccines

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“…Sub-genotype VIId viruses have been recovered from poultry in China (1998-2013) (Yu et al, 2001;Wan et al, 2002;Liu et al, 2003;Zhang et al, 2010;Wu et al, 2011;Zhang et al, 2014), South Korea (2000Korea ( -2005 (Cho et al, 2008), and Colombia (2006 (Hines et al, 2012;Benson et al, 2015). Additionally, sporadic reports of sub-genotype VIId viruses originate from samples collected from poultry in Israel, South Africa, Ukraine, and Venezuela during 2004-2009(Perozo et al, 2012Dortmans et al, 2014;Benson et al, 2015). Sub-genotype VIId viruses have also been recovered from wild bird with signs of clinical disease, including the endangered crested ibis (Nipponia nippon), in China and various other taxa in Serbia during 2006-2007, suggesting a capacity for large mobility widespread circulation for this group of viruses and potential for spillover of viruses from poultry into wild birds (Vidanovic et al, 2011;Chen et al, 2013;Benson et al, 2015).…”

Section: Class II Genotype Viimentioning

confidence: 99%

Temporal, geographic, and host distribution of avian paramyxovirus 1 (Newcastle disease virus)

Dimitrov

Ramey

Qiu

et al. 2016

Infection, Genetics and Evolution

235

227

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Newcastle disease is caused by virulent forms of avian paramyxovirus of serotype 1 (APMV-1) and has global economic importance. The disease reached panzootic proportions within two decades after first being identified in 1926 in the United Kingdom and Indonesia and still remains endemic in many countries across the world. Here we review information on the host, temporal, and geographic distribution of APMV-1 genetic diversity based on the evolutionary systematics of the complete coding region of the fusion gene. Strains of APMV-1 are phylogenetically separated into two classes (class I and class II) and further classified into genotypes based on genetic differences. Class I viruses are genetically less diverse, generally present in wild waterfowl, and are of low virulence. Class II viruses are genetically and phenotypically more diverse, frequently isolated from poultry with occasional spillovers into wild birds, and exhibit a wider range of virulence. Waterfowl, cormorants, and pigeons are natural reservoirs of all APMV-1 pathotypes, except viscerotropic velogenic viruses for which natural reservoirs have not been identified. Genotypes I and II within class II include isolates of high and low virulence, the latter often being used as vaccines. Viruses of genotypes III and IX that emerged decades ago are now isolated rarely, but may be found in domestic and wild birds in China. Containing only virulent viruses and responsible for the majority of recent outbreaks in poultry and wild birds, viruses from genotypes V, VI, and VII, are highly mobile and have been isolated on different continents. Conversely, virulent viruses of genotypes XI (Madagascar), XIII (mainly Southwest Asia), XVI (North America) and XIV, XVII and XVIII (Africa) appear to have a more limited geographic distribution and have been isolated predominantly from poultry.

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“…It is widely recognized that the ND vaccines which are phylogenetically closer to circulating field viruses appear to be more efficient in ND prevention in terms of reducing the virulent virus load and shedding [ 7 , 9 , 10 ]. Moreover, researchers have recently found that when the level of humoral antibody titers increased in vaccinated birds, the number of infected birds and the amount of virulent NDV shed would be decreased [ 11 , 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of the HN Antigenic Difference between the Vaccine Strain and the Challenge Strain of Newcastle Disease Virus on Virus Shedding and Transmission

Liu

Jun

et al. 2017

Viruses

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Newcastle disease (ND) leading to heavy economic losses to the poultry industry worldwide is caused by Newcastle disease virus (NDV). Even though intensive vaccination programs have been implemented in many countries, virulent NDV can still be frequently isolated in well-vaccinated flocks. We compared the protection efficiency of LaSota and two sub-genotype VIId vaccines, NDV/AI4 and NDV O/AI4, in which NDV O/AI4 was constructed by replacing the hemagglutinin–neuraminidase (HN) gene of the vaccine strain NDV/AI4 with that from the variant NDV strain JS-14-12-Ch by the cross hemagglutination inhibition test and immune protection test. The number of birds shedding the virus and the titer of the shedding virus from the challenged birds were tested to evaluate the protection efficiency in the immune protection test. The cross hemagglutination inhibition and neutralization tests between JS-14-12-Ch and the three vaccines displayed a significant antigenic difference between JS-14-12-Ch and LaSota or NDV/AI4, but not between JS-14-12-Ch and NDV O/AI4. The results of the immune protection test showed that NDV O/AI4 could provide improved protection as determined by a significant decrease in both the number of birds shedding the virus and the titer of the shedding virus from the challenged birds. The results in this study indicated that the antigenic similarity between the vaccine strain and the challenge strain is important in reducing the shedding of virulent virus in which the congruence of the NDV HN protein may play a critical role.

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Field vaccinated chickens with low antibody titres show equally insufficient protection against matching and non-matching genotypes of virulent Newcastle disease virus

Cited by 19 publications

References 21 publications

A Herpesvirus of Turkey-Based Vector Vaccine Reduces Transmission of Newcastle Disease Virus in Commercial Broiler Chickens with Maternally Derived Antibodies

A Herpesvirus of Turkey-Based Vector Vaccine Reduces Transmission of Newcastle Disease Virus in Commercial Broiler Chickens with Maternally Derived Antibodies

Temporal, geographic, and host distribution of avian paramyxovirus 1 (Newcastle disease virus)

Effects of the HN Antigenic Difference between the Vaccine Strain and the Challenge Strain of Newcastle Disease Virus on Virus Shedding and Transmission

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