Field Study of the Prophylactic Value of Pertussis Vaccine

Perkins, James E.; Stebbins, Ernest L.; Silverman, Hilda Freeman; Lembcke, Paul A.; Blum, Bernard M.

doi:10.2105/ajph.32.1.63

Cited by 10 publications

(1 citation statement)

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“…The value of the vaccine was resolved in large part by a study devised by Hilda Freeman Silverman in conjunction with Perkins and others. 45 Epidemiology has also been useful in giving indirect information as to the value of immunization. A statistical compilation and analysis of a number of milk-borne outbreaks investigated by the author and others 46 offered evidence that the immunity to streptococcal infections was of a complex nature and that immunity to exotoxin conferred little protection against bacterial invasion.…”

mentioning

confidence: 99%

Statistics and Medical Knowledge

Ingraham¹

1958

Am J Public Health Nations Health

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mentioning

confidence: 99%

Statistics and Medical Knowledge

Ingraham¹

1958

Am J Public Health Nations Health

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Current Status of Prophylaxis by Hemophilus Pertussis Vaccine

Felton¹,

Willard²

1944

JAMA

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The influence of virulence on the immunising potency for mice of hæmo‐philus pertussis, phase I

Gray

1947

J. Pathol.

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THE increasing confidence in pertussis immunisation, based on many favourable reports on its field application, was disturbed by the failure of the recent trials in Oxford to demonstrate any protection in children following the use of a phase I vaccine (McFarlan, Topley and Fisher, 1945). It is understood (McFarlan, 1946, personal communication) that it was not the intention of these workers to discredit pertussis vaccination as a practice, but merely to show that a vaccine produced by a reputable institution from phase I organisms was not ips0 facto an effective prophylactic agent. Moreover, McFarlan and his colleagues in their paper suggested the possibility that the vaccine may have been a t fault and that, although it was possible to criticise points in the planning or statistical analysis of some of the successful American trials, it was difficult to avoid the conclusion that vaccination conferred some protection.Previous experiments (Gray, 1946) showed that significant variations may occur in the mouse virulence of a single strain of H . pertussis, determined by the intranasal route, within the present concept of phase I. Enhancement in virulence is influenced by decreasing physiological age of the cultures and is most evident after 24 hours' incubation. Furthermore, growth in the developing egg produces organisms which are more virulent than those of equivalent age on Bordet-Gengou medium.The experiments here recorded represent an attempt to provide evidence that not all phase I vaccines possess equal immunising potency and that vaccines made from highly virulent young cultures are more suitable for vaccine production than the older cultures hitherto employed in animal and human vaccination. Immunising potency is a purely relative character, dependent upon the animal species and the experimental conditions, and it is therefore unwise to attempt to relate directly the results of experiments in mice to the response in children. But I feel that my results offer some indication of the possible reason for the failure of the Oxford trials. J. PATH. BACT.-VOL.LIX 235

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Field Study of the Prophylactic Value of Pertussis Vaccine

Cited by 10 publications

References 0 publications

Statistics and Medical Knowledge

Statistics and Medical Knowledge

Current Status of Prophylaxis by Hemophilus Pertussis Vaccine

The influence of virulence on the immunising potency for mice of hæmo‐philus pertussis, phase I

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