Field detection of resistance to isometamidium chloride and diminazene aceturate in Trypanosoma vivax from the region of the Boucle du Mouhoun in Burkina Faso

Sow, Adama; Sidibé, Issa; Bengaly, Zakaria; Marcotty, Tanguy; Séré, Modou; Diallo, A.; Vitouley, H.; Ouédraogo, M.; Akoda, Gilbert Komlan; Bossche, Peter Van Den; Abbeele, Jan Van Den; Deken, R. De; Delespaux, V.

doi:10.1016/j.vetpar.2011.12.019

Cited by 32 publications

(25 citation statements)

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“…Animal trypanosomiasis is the most prevalent cattle disease in Africa and South America. It causes annual livestock production losses of several billions for the African continent and strongly hinders agricultural and economical development of emerging countries (Oliveira et al, 2009;Batista et al, 2012;Pimentel Dde et al, 2012;Sow et al, 2012). Trypanosoma vivax and T. congolense are the most prominent parasites involved in this disease that also affects sheep and goats.…”

Section: Introductionmentioning

confidence: 99%

Erythrophagocytosis of desialylated red blood cells is responsible for anaemia duringTrypanosoma vivaxinfection

et al. 2013

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SummaryTrypanosomal infection-induced anaemia is a devastating scourge for cattle in widespread regions. Although Trypanosoma vivax is considered as one of the most important parasites regarding economic impact in Africa and South America, very few in-depth studies have been conducted due to the difficulty of manipulating this parasite. Several hypotheses were proposed to explain trypanosome induced-anaemia but mechanisms have not yet been elucidated. Here, we characterized a multigenic family of trans-sialidases in T. vivax, some of which are released into the host serum during infection. These enzymes are able to trigger erythrophagocytosis by desialylating the major surface erythrocytes sialoglycoproteins, the glycophorins. Using an ex vivo assay to quantify erythrophagocytosis throughout infection, we showed that erythrocyte desialylation alone results in significant levels of anaemia during the acute phase of the disease. Characterization of virulence factors such as the trans-sialidases is vital to develop a control strategy against the disease or parasite.

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Section: Introductionmentioning

confidence: 99%

Erythrophagocytosis of desialylated red blood cells is responsible for anaemia duringTrypanosoma vivaxinfection

et al. 2013

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“…Control of animal trypanosomosis is one of the key components to improve the productive opportunities of rural communities in tsetse-infested areas. This has been addressed using trypanocidal drugs which are limited in number and have been under extensive use for over 40 years with little or no regular monitoring (Stein et al, 2011;Chitanga et al, 2011;Mungube et al, 2012;Sow et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

“…For instance trypanocidal drug resistance was observed for isometamidium chloride and diminazene aceturate against Trypanosoma congolense, Trypanosoma vivax and Trypanosoma evansi (Mungube et al, 2012;Sow et al, 2012;Kumar et al, 2012). The high infestation of lowlying areas by tsetse flies as well as T. congolense, T. vivax and T. bruceiwas also reported more than a decade back in Southern parts of Ethiopia (Abebe, 2005;Miruk et *Corresponding author.…”

Section: Introductionmentioning

confidence: 99%

Sensitivity of Trypanosoma congolense field isolates in experimentally infected calves in Konso district, Southern Ethiopia to isomethamidium and diminazene

Ashenafi¹,

Gewado²,

Hailu³

2014

J. Vet. Med. Anim. Health

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Study on sensitivity to diminazene aceturate 3.5 mg/kg and isometamidium chloride 0.5 mg/kg in tenzebu calves experimentally infected with two field isolates of Trypanosoma congolense (ET/07/Konso 59 and ET/07/Konso 114) was undertaken in Konso district, Southern Ethiopia. Calves were monitored for clinical and parasitological parameters during three months. At day 15 postinfection, corresponding to peak parasitaemia, they were treated with Diminasan ® 3.5 mg/kg body weight via deep intramuscular route. Out of ten calves, only two remained parasitologically negative for 12 and 15 days after treatment with Diminasan ® . Once relapse/breakthrough infection was detected in two calves, parasitemia persisted until they get second treatment with Veridium ® 0.5 mg/kg body weight. However, linear regression analysis of the effects of persistent trypanosomal infections on mean packed cell volume (PCV) and loss of body condition in relation to the initial recordings in the relapsed calves was not statistically significant. Results of the trypanocidal drug sensitivity study revealed the presence of T. congolense populations exhibiting resistance to diminazene aceturate. It is strongly recommended that legislations be devised and implemented to ensure that only quality and effective trypanocidal drugs should get access to the market.

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“…Treatments with trypanocidal drugs constitute the most frequently used method for controlling trypanosomosis and maintaining susceptible breeds in tsetse infested areas. However, extended use of these drugs led to the development of chemoresistance in all trypanosomosis enzootic areas of Burkina Faso (Clausen et al, 1992;McDermott et al, 2003;Talaki et al, 2007;Sow et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Baseline survey of animal trypanosomosis in the region of the Boucle du Mouhoun, Burkina Faso

Sow

Ganaba

Percoma

et al. 2013

Research in Veterinary Science

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In view of gathering baseline information about the prevalence of animal trypanosomosis, the Pan African Tsetse and Trypanosomiasis Eradication Campaign (PATTEC) funded a cross sectional survey in the Region of the Boucle du Mouhoun which constitutes the Northern limit of the tsetse distribution in Burkina. This cross sectional study was carried out in 53 villages located in the 6 provinces of the region. A total of 2002 cattle, 1466 small ruminants and 481 donkeys were sampled. This survey showed that about 25% of the cattle had been treated with trypanocidal drugs within 3 months before the survey compared to 3% and 0.42% for the small ruminants and donkeys respectively. Parasitological prevalence in cattle was low: 0.77% (95% C.I. 0.30-1.95%). No goats and three donkeys were found infected with trypanosomes. Infections were mainly due to Trypanosoma vivax (75.0%) with cases of T. congolense (25.0%). In cattle, the serological prevalence of trypanosomosis, for the entire Region of the Boucle du Mouhoun, was 34.2% (95%C.I. 26.1-43.4%). For sheep, goats and donkeys, the prevalence were of 20.9% (95%C.I. 12.2-33.5%), 8.5% (95%C.I. 5.7-12.5%) and 5.8% (95%C.I. 3.9-8.6%) respectively.The age and distance to the river were the two main risk factors associated with seropositivity.

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Field detection of resistance to isometamidium chloride and diminazene aceturate in Trypanosoma vivax from the region of the Boucle du Mouhoun in Burkina Faso

Cited by 32 publications

References 19 publications

Erythrophagocytosis of desialylated red blood cells is responsible for anaemia duringTrypanosoma vivaxinfection

Erythrophagocytosis of desialylated red blood cells is responsible for anaemia duringTrypanosoma vivaxinfection

Sensitivity of Trypanosoma congolense field isolates in experimentally infected calves in Konso district, Southern Ethiopia to isomethamidium and diminazene

Baseline survey of animal trypanosomosis in the region of the Boucle du Mouhoun, Burkina Faso

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