Field desorption mass spectrometry of sodium and potassium salts

Games, David E.; Games, Marguerite P. L.; Jackson, Anthony H.; Olaveson, A.K.; Rossiter, M.; Winterburn, P. J.

doi:10.1016/s0040-4039(01)92260-9

Cited by 27 publications

(6 citation statements)

References 11 publications

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“…After suitable derivatization, gas chromatography mass spectrometry (GC/MS) has been used to identify and quantify the parent steroid.lV2 Alternatively, in some instances the sulphate group may be displaced in a suitable derivatization r e a~t i o n .~-~ The polarity and involatility of steroid sulphates have generally precluded direct mass spectrometric analyses though field desorption mass spectrometric studies of a single steroid sulphate have been reported. 6 The introduction of fast atom bombardment (FAB) mass s ectrometry with suitable sample handling techniques has provided a means for the direct analysis of polar, involatile compounds. The applicability of the new technique to the analysis of steroid sulphates has, therefore, been evaluated, with particular reference to the achievement of sensitivity and selectivity, and to the potential for quantitative analyses.…”

Section: Introductionmentioning

confidence: 99%

Fast atom bombardment mass spectrometry of steriod sulphates: Qualitative and quantitative analyses

Gaskell

Brownsey

Brooks

et al. 1983

Biol. Mass Spectrom.

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Negative ion mass spectra obtained by fast atom bombardment of glycerol solutions of steroid sulphates include the steroid sulphate anion as the single prominent feature. High sensitivity is achieved, with full spectra obtained for samples of less than 15 ng. Differentiation of the isomeric steroids, dehydroepiandrosterone sulphate and testosterone sulphate, is made by comparison of the products of fragmentation of metastable ions. Analyses of biological extracts suffer from poorly-understood matrix effects which may cause partial or complete suppression of the signal attributable to steroid sulphates. Use of an immunoadsorption extraction technique, however, has permitted the detection and approximate quantification (using a (2H2) analogue as internal standard) of dehydroepiandrosterone sulphate in blood plasma. Interference from glycerol background is avoided by preparation of the pentafluorobenzyloxime derivatives.

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Section: Introductionmentioning

confidence: 99%

Fast atom bombardment mass spectrometry of steriod sulphates: Qualitative and quantitative analyses

Gaskell

Brownsey

Brooks

et al. 1983

Biol. Mass Spectrom.

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“…As might be expected from the previous investigation on the formation of ions in FDMS of salts no molecular ion is detected. Similarly as in the studies of quaternary ammonium salts (Brent et al, 1973), alkali salts of bile acids (Games et al, 1974), and other onium substances (Sammons et al, 1975; Rollgen and Schulten, 1975; Wood et al, 1975;Schulten and Rollgen, 1975b) the cation appears with high relative abundances. The jV-dodecylguanidinium ion at m/e…”

Section: Methodsmentioning

confidence: 57%

Field desorption mass spectrometry of commercial pesticides and mixtures of pesticides

Schulten¹

1976

J. Agric. Food Chem.

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“…Amino acid analyses were performed on a Glenco MM-70 amino acid analyzer using a single column methodology with the Pico Buffer (R) System supplied by Pierce Chemical Company, Rockford, 111.34 Accumulation of Arogenate. Cultures of a multiply blocked aromatic auxotroph of N. crassa (75001 /5212/C-167) were maintained at room temperature by conidial transfer on the solidified media of Westergaard and Mitchell15 containing 250 mg per L each of Lphenylalanine, L-tyrosine, and L-tryptophan (25 mL per 250-mL Erlenmeyer flask). The accumulation medium for arogenate15 contained 1 % (w/v) sucrose, 25 mg per L each of L-tyrosine and L-tryptophan as well as 5 mg per L of L-phenylalanine.…”

Section: Methodsmentioning

confidence: 99%

Structure of arogenate (pretyrosine), an amino acid intermediate of aromatic biosynthesis

Zamir¹,

Jensen²,

Arison³

et al. 1980

J. Am. Chem. Soc.

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19) Epstein, L. M.; Straub, D. K.; Maricondi, C. Inorg. Chem. 1967, 6, 1720-1724. (20) Brunori, M.; Giacometti, G. M.; Antonini, E.; Wyman, J. 1231.(26) The optical spectra show that although K2 is small but finite, for purposes of the analysis of kinetic data we may i nore the binding of the second base. The linear dependence of k w on [CO? and its simultaneous independence of [Im-] show that loss of base and subsequent CO binding contribute minimally compared with direct CO addition to the five-coordinate species.Abstract: L-(8S)-Arogenate (previously named pretyrosine), a newly recognized precursor of L-phenylalanine and L-tyrosine biosynthesis, is widely distributed in nature. Proof of structure for arogenate, 0-( I-carboxy-4-hydroxy-2,5-cyclohexadien-lyl)alanine, was established through the application of spectroscopic techniques (ultraviolet, 'H NMR, I3C NMR, and mass spectrometry) following the application of an improved procedure for isolation of L-arogenate from the culture supernatant of a mutant strain of Neurospora crassa. The ( S ) configuration of the chiral amino acid carbon at C-8 of L-arogenate was established by circular dichroism.

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Field desorption mass spectrometry of sodium and potassium salts

Cited by 27 publications

References 11 publications

Fast atom bombardment mass spectrometry of steriod sulphates: Qualitative and quantitative analyses

Fast atom bombardment mass spectrometry of steriod sulphates: Qualitative and quantitative analyses

Field desorption mass spectrometry of commercial pesticides and mixtures of pesticides

Structure of arogenate (pretyrosine), an amino acid intermediate of aromatic biosynthesis

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