Field-based performance of three pre-market rapid hepatitis C virus antibody assays in STAHR (Study to Assess Hepatitis C Risk) among young adults who inject drugs in San Diego, CA

Jewett, Amy; Smith, Bryce D.; Garfein, Richard S.; Cuevas-Mota, Jazmine; Teshale, Eyasu H.; Weinbaum, Cindy M.

doi:10.1016/j.jcv.2012.04.003

Cited by 37 publications

(36 citation statements)

References 21 publications

(32 reference statements)

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“…The Chembio assay was evaluated in three studies using serum [22], fingerstick blood [17,23] and oral fluid [17,23] from PWID (n=2,357). The MedMira assay was evaluated in three studies using serum [22] and fingerstick blood [23] from PWID (n=1,940).…”

Section: Rapid Assaysmentioning

confidence: 99%

“…The MedMira assay was evaluated in three studies using serum [22] and fingerstick blood [23] from PWID (n=1,940). The OraSure assay was evaluated in five studies, using serum [20][21][22], fingerstick blood [20,21,23] and oral fluid [19][20][21]23] from PWID, [17,19,22,23] low-risk individuals [21], and those with signs or symptoms of hepatitis C infection [20] (n=5,058).…”

Section: Rapid Assaysmentioning

confidence: 99%

“…Negativity is defined by either nonreactivity or negativity by RIBA. Three of the studies also included comparison to algorithms specific to the respective manufacturer's inserts [17,22,23]. Additionally, one of the sites in the field study [23] did not utilize the CDC algorithm and therefore the reported results were based upon comparison with the conventional EIA only.…”

Section: Reference Assaysmentioning

confidence: 99%

“…Additionally, many PWID who are tested for HCV using conventional assays do not return to receive their results. Point-of-care, rapid HCV testing enables the delivery of results at the time of testing [17]. PWID who receive rapid HIV tests have been shown to be more likely to be informed of their results than those tested with conventional assays, who must return at a later date [18].…”

Section: Introductionmentioning

confidence: 99%

“…Here, we summarize the outcomes of six studies [17,[19][20][21][22][23] conducted in the US that examined the performance characteristics of rapid anti-HCV tests and propose a research agenda to support their adoption in the field.…”

Section: Introductionmentioning

confidence: 99%

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Rapid diagnostic HCV antibody assays

Smith

Jewett²,

Drobeniuc³

et al. 2012

Antivir Ther

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Approximately 4.1 million Americans have been infected with HCV and 45-85% of chronically infected persons are unaware of their status. Rapid anti-HCV assays can assist and expedite the identification of those unaware of their infection. Performance characteristics of pre-market rapid anti-HCV assays (Chembio, MedMira and OraSure) have been evaluated. Their sensitivity (78.9-99.3%) and specificity (80-100%) varied. Future investigations could include evaluation of rapid anti-HCV tests in persons who are coinfected with HCV and HIV, and development of rapid HCVantigen tests and nucleic acid tests.

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Section: Rapid Assaysmentioning

confidence: 99%

Section: Rapid Assaysmentioning

confidence: 99%

Section: Reference Assaysmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Rapid diagnostic HCV antibody assays

Smith

Jewett²,

Drobeniuc³

et al. 2012

Antivir Ther

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Impact of rapid point-of-care screening tests for the identification of chronic hepatitis C infection

Liapakis

Lim

2013

Hepatology

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Background: 170 million persons worldwide are infected with hepatitis C, many of whom are undiagnosed. Although rapid diagnostic tests (RDTs) and point-of-care tests (POCTs) provide a time-and cost-saving alternative to conventional laboratory tests, their global uptake partly depends on their performance. [CI, 92.2% to 99.6%]). Limitation:-Lack of data prevented sensitivity analyses of specific tests. Conclusion: Data suggest that POCTs of blood (serum, plasma, or whole blood) have the highest accuracy, followed by RDTs of serum or plasma and POCTs of oral fluids. Given their accuracy, convenience, and quick turnaround time, RDTs and POCTs may be useful in expanding first-line screening for hepatitis C. Primary Funding Source: Canadian Institutes of Health Research.

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High prevalence of binge drinking among people living with HIV in four African countries

et al. 2018

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IntroductionExcessive alcohol consumption leads to unfavourable outcomes in people living with HIV (PLHIV), including reduced adherence to antiretroviral therapy (ART) and engagement into care. However, there is limited information on alcohol consumption patterns among PLHIV in sub‐Saharan Africa.MethodsUsing a cross‐sectional approach, the Alcohol Use Disorders Identification Test (AUDIT‐C) was administered to PLHIV attending HIV clinics in Côte d'Ivoire, Togo, Senegal and Zambia (2013 to 2015). Hazardous drinking was defined as an AUDIT‐C score ≥4 for men or ≥3 for women, and binge drinking as ≥6 drinks at least once per month. The prevalence of binge drinking was compared to estimates from the general population using data from the World Health Organization. Factors associated with binge drinking among persons declaring any alcohol use in the past year were assessed using a logistic regression model to estimate odds ratio (OR) and their corresponding 95% confidence intervals (CI).ResultsAmong 1824 PLHIV (median age 39 years, 62.8% female), the prevalence of hazardous alcohol use ranged from 0.9% in Senegal to 38.4% in Zambia. The prevalence of binge drinking ranged from 14.3% among drinkers in Senegal to 81.8% in Zambia, with higher estimates among PLHIV than in the general population. Male sex (OR 2.4, 95% CI 1.6 to 3.7), tobacco use (OR 1.7, 95% CI 1.0 to 2.9) and living in Zambia were associated with binge drinking.ConclusionsAlcohol consumption patterns varied widely across settings and binge drinking was more frequent in HIV‐positive individuals compared to the general population. Interventions to reduce excessive alcohol use are urgently needed to optimize adherence in the era of universal ART.

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Field-based performance of three pre-market rapid hepatitis C virus antibody assays in STAHR (Study to Assess Hepatitis C Risk) among young adults who inject drugs in San Diego, CA

Cited by 37 publications

References 21 publications

Rapid diagnostic HCV antibody assays

Rapid diagnostic HCV antibody assays

Impact of rapid point-of-care screening tests for the identification of chronic hepatitis C infection

High prevalence of binge drinking among people living with HIV in four African countries

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