Ficus deltoidea ameliorates biochemical, hormonal, and histomorphometric changes in letrozole-induced polycystic ovarian syndrome rats

Haslan, Muhammad Aliff; Samsulrizal, Nurdiana; Zin, Noor Syaffinaz Noor Mohamad; Shirazi, Farshad H.; Goh, Yong Meng

doi:10.21203/rs.3.rs-395007/v1

Cited by 3 publications

(2 citation statements)

References 38 publications

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“…The present results show elevation in plasma MDA level that is accompanied with reduced glutathione (GSH) level in PCOS group compared with control. This observation is consistent with a recent study in PCOS patients that found elevated circulating MDA (Uçkan et al 2022) and in experimental animals (Haslan et al 2021). Usually, PCOS present with higher levels of blood lipids (Klimczak et al, 2015).…”

Section: Discussionsupporting

confidence: 93%

Acetate meliorates depressive-like behaviour in a rat model of PCOS through suppression of HDAC2 expression and DNA methylation

Wolugbom

Areloegbe

Olaniyi

2022

Preprint

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ObjectivePolycystic Ovarian Syndrome (PCOS) is the most common endocrine disorder among women of reproductive age. PCOS has been demonstrated to induce depressive-like behaviour. Epigenetic alterations such as histone deacetylation (HDAC) and DNA methylation have been suggested in major depression. However, their effects with respect to neuroinflammation are not clear. This study therefore investigated the pathogenic role of epigenetic modification in PCOS-associated depression and the therapeutic potential of HDACi, acetate.MethodsAdult female Wistar rats (120-150 g) were allotted into groups (n = 6/group) namely: control (vehicle; p.o.), acetate-treated (200 mg/kg), letrozole (LET)-treated (1 mg/kg) and LET+Acetate-treated. Letrozole was administered for 21 days to induce PCOS.ResultsTreatment with letrozole caused hyperandrogenism, hyperinsulinemia and disrupted ovarian morphology with evidence of degenerated follicles. In addition, these animals showed depressive-like behaviours and increased expression of HDAC2 and DNA methyltransferase in PFC and hippocampal tissues. Biochemical analyses showed elevated NF-kB and acetylcholine (ACH) levels in PFC and hippocampus as well as plasma lipid peroxidation and impaired antioxidant system in LET-treated animals. Histological analysis of PFC and hippocampus showed neurodegeneration in LET-treated animals compared with control. However, these alterations were attenuated when treated with acetate.ConclusionThe study demonstrates that PCOS-associated depression is characterised by neuroinflammation and elevated ACH levels, and this is associated with increased expression of HDAC2 and DNA hypermethylation in PFC and hippocampus. Besides, the study suggests that acetate ameliorates PCOS-associated depression through the suppression of prefrontal and hippocampal DNA methyltransferase and prefrontal but not hippocampal HDAC2 expression.

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Section: Discussionsupporting

confidence: 93%

Acetate meliorates depressive-like behaviour in a rat model of PCOS through suppression of HDAC2 expression and DNA methylation

Wolugbom

Areloegbe

Olaniyi

2022

Preprint

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“…In this study, ovarian SOD, CAT, and total peroxidase concentrations were much lower in PCOS rats, whereas ovarian MDA was significantly greater in PCOS rats, which was consistent with earlier research on PCOS patients [ 86 , 87 ]. In this paradigm, oxidative stress was verified in PCOS rats.…”

Section: Discussionsupporting

confidence: 93%

Therapeutic effects of aqueous extract of bioactive active component of Ageratum conyzoides on the ovarian-uterine and hypophysis-gonadal axis in rat with polycystic ovary syndrome: Histomorphometric evaluation and biochemical assessment

et al. 2022

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Crude extract of Ficus deltoidea Jack (FD) as a natural biological therapy

Abdulrahman

2023

Exploration of Targeted Anti-Tumor Therapy

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Aim: This study shows how important it is to coordinate research on Ficus deltoidea Jack (FD) so that results from different sources can be compared directly and a scientific conclusion can be made. Methods: The author looked for research papers on Ficus (F.) deltoidea on Google Scholar, Science Direct, Google.com, Wiley, PubMed, Hindawi, Springer, and other related databases. This analysis excludes data that cannot be trusted, thesis papers, and review articles about F. deltoidea. Results: In traditional medicine, the plant’s leaves and syconia are used to cure a wide variety of ailments, including itchiness, diarrhoea, cancer, sexual dysfunction, age-related issues, malaria, cancer, anxiety, pain, constipation, fever, diabetes, tooth pain, and tooth decay. In vitro and in vivo studies showed the effectiveness of the leaves against cancer cell lines. Conclusions: Based on the existing research on the health benefits of FD, it is critical to focus on its more active constituents and their identification, determination, further development, and, most importantly, standardization of the leaves for the management and treatment of cancer and its related cases. More research is needed before it can be considered a promising herbal source of novel medication candidates for treating various disorders.

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Ficus deltoidea ameliorates biochemical, hormonal, and histomorphometric changes in letrozole-induced polycystic ovarian syndrome rats

Cited by 3 publications

References 38 publications

Acetate meliorates depressive-like behaviour in a rat model of PCOS through suppression of HDAC2 expression and DNA methylation

Acetate meliorates depressive-like behaviour in a rat model of PCOS through suppression of HDAC2 expression and DNA methylation

Therapeutic effects of aqueous extract of bioactive active component of Ageratum conyzoides on the ovarian-uterine and hypophysis-gonadal axis in rat with polycystic ovary syndrome: Histomorphometric evaluation and biochemical assessment

Crude extract of Ficus deltoidea Jack (FD) as a natural biological therapy

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