Ficus cordata Thunb (Moraceae) is a Potential Source of Some Hepatoprotective and Antioxidant Compounds

Donfack, Hubert J.; Kengap, Rodrigue T.; Ngameni, Barthelemy; Chuisseu, Pascal Dieudonne Djamen; Tchana, A.; Buonocore, Daniela; Ngadjui, Bonaventure T.; Moundipa, Paul Fewou; Marzatico, Fulvio

doi:10.5567/pharmacologia.2011.137.145

Cited by 10 publications

(5 citation statements)

References 17 publications

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“…Among the plants used in the treatment of diseases related to the liver, the most promising are Ficus cordata and Irvingia gabonensis , from which compounds with hepatoprotective properties have been isolated [86,97]. Among the isolated compounds, 3-friedelanone (53) might be useful for the prevention of toxin-induced and free radical-mediated liver diseases [86].…”

Section: Resultsmentioning

confidence: 99%

Cameroonian medicinal plants: a bioactivity versus ethnobotanical survey and chemotaxonomic classification

Ntie‐Kang

Lifongo

Mbaze

et al. 2013

BMC Complement Altern Med

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BackgroundIn Cameroon herbs are traditionally used to meet health care needs and plans are on the way to integrate traditional medicine in the health care system, even though the plans have not been put into action yet. The country however has a rich biodiversity, with ~8,620 plant species, some of which are commonly used in the treatment of several microbial infections and a range of diseases (malaria, trypanosomiasis, leishmaniasis, diabetes and tuberculosis).MethodsOur survey consisted in collecting published data from the literature sources, mainly from PhD theses in Cameroonian university libraries and also using the author queries in major natural product and medicinal chemistry journals. The collected data includes plant sources, uses of plant material in traditional medicine, plant families, region of collection of plant material, isolated metabolites and type (e.g. flavonoid, terpenoid, etc.), measured biological activities of isolated compounds, and any comments on significance of isolated metabolites on the chemotaxonomic classification of the plant species. This data was compiled on a excel sheet and analysed.ResultsIn this study, a literature survey led to the collection of data on 2,700 secondary metabolites, which have been previously isolated or derived from Cameroonian medicinal plants. This represents distinct phytochemicals derived from 312 plant species belonging to 67 plant families. The plant species are investigated in terms of chemical composition with respect to the various plant families. A correlation between the known biological activities of isolated compounds and the ethnobotanical uses of the plants is also attempted. Insight into future direction for natural product search within the Cameroonian forest and Savanna is provided.ConclusionsIt can be verified that a phytochemical search of active secondary metabolites, which is inspired by knowledge from the ethnobotanical uses of medicinal plants could be very vital in a drug discovery program from plant-derived bioactive compounds.

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Section: Resultsmentioning

confidence: 99%

Cameroonian medicinal plants: a bioactivity versus ethnobotanical survey and chemotaxonomic classification

Ntie‐Kang

Lifongo

Mbaze

et al. 2013

BMC Complement Altern Med

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“…Tocopherol stabilizes ALT and argininosuccinic acid lyase levels as well as reduced histopathological signs of portal inflammation, fatty changes and necrosis in experimental rabbits [59]. Hepatoprotective and antioxidant activity of stigmasterol was shown by Donfack and his group [60] on CCL 4 treated animals. Sitosterol demonstrated antihepatotoxic activities by normalization of serum transaminases and hepatic antioxidant enzymes in hepato-compromised animals [61].…”

Section: Discussionmentioning

confidence: 96%

Assessment of hepatoprotective potential of N. indicum leaf on haloalkane xenobiotic induced hepatic injury in Swiss albino mice

Dey

Dutta

Sarkar

et al. 2015

Chemico-Biological Interactions

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“…showed that the stem bark of this plant is used by some western Cameroonian traditional healers for the treatment of jaundice; who can be a symptom of several related liver diseases (Donfack, 2011).…”

Section: Additional Ethnopharmacological Investigationsmentioning

confidence: 99%

Genetic Characterization and in vitro propagation of three medicinal plants collected from high altitude sites

2015

Int. J. Biosci.

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Characterization is the first step in the conservation and utilization of indigenous genetic resources. A protocol for micro propagation of three important high altitude medicinal plant species (Ficus cordata ssp. salicifolia (vahl) C.C. Berg, Ficus palmata Forsk and Pulicaria vulgaris Gaertner) was established using nodal segments harboring axillary buds as explants. RAPD-PCR technique was used to characterize the three studied medicinal plants. In vitro stages of shoot initiation and shoot multiplication were studied by culturing the explants on Murashige and Skoog medium (MS). MS medium was supplemented with different concentrations and combinations of benzyl aminopurine, kinetin, αnaphthalene acetic acid and 2-isopentyladenine. For Ficus cordata ssp. salicifolia (vahl) C.C. Berg, the highest percentage of shoot initiation (86.6%) and the maximum average number of multiplied shoots (3.25) were observed on MS medium containing 0.5 mg/ l BAP + 1 mg / l 2iP.For Ficus palmata Forsk, the highest percentage of shoot initiation (92%) was observed on MS medium supplemented with 2.5 mg/ l BAP + 1.0 mg/ l Kn, whereas maximum average number of multiplied shoots (3.25) was produced on MS medium with 2.0 mg/ l BAP. For Pulicaria vulgaris Gaertner, the highest percentage of shoot initiation (93.3) was achieved on MS medium containing 0.1 mg/ l Kn + 3.0 mg / l 2iP with an average of (3.75) shoots / explants. Fourteen RAPD primers have successful PCR amplification and produced informative and distinct electrophoretic banding pattern. Different DNA fragments were produced and utilized for characterizing the studied plants. RAPD markers are yield different information and detect differences along the entire genome. Different studies are needed to collect, characterize and propagate other important medicinal plants from Taif high altitude regions.

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Ficus cordata Thunb (Moraceae) is a Potential Source of Some Hepatoprotective and Antioxidant Compounds

Cited by 10 publications

References 17 publications

Cameroonian medicinal plants: a bioactivity versus ethnobotanical survey and chemotaxonomic classification

Cameroonian medicinal plants: a bioactivity versus ethnobotanical survey and chemotaxonomic classification

Assessment of hepatoprotective potential of N. indicum leaf on haloalkane xenobiotic induced hepatic injury in Swiss albino mice

Genetic Characterization and in vitro propagation of three medicinal plants collected from high altitude sites

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