Ficus carica aqueous extract alleviates delayed gastric emptying and recovers ulcerative colitis-enhanced acute functional gastrointestinal disorders in rats

Rtibi, Kaïs; Grami, Dhekra; Wannes, Dalanda; Selmi, Slimen; Amri, Mohamed; Sebaï, Hichem; Marzouki, Lamjed

doi:10.1016/j.jep.2018.06.001

Cited by 33 publications

(17 citation statements)

References 49 publications

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“…Interestingly, we observed significant variations in serum TChol and LDL, which were consistent with the findings of Rtibi et al. ( 50 ) and Zheng et al. ( 51 ).…”

Section: Discussionsupporting

confidence: 93%

“…Our results also showed severe intestinal histological damage and disruption of the structural integrity of TJ in the DSS group, which further indicated that DSS successfully induced colitis. Interestingly, we observed significant variations in serum TChol and LDL, which were consistent with the findings of Rtibi et al (50) and Zheng et al (51). In addition, the TJ structural damage could be one of the reasons of elevated serum lipid levels.…”

Section: Discussionsupporting

confidence: 92%

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Multi-Omics Analysis of the Gut-Liver Axis Reveals the Mechanism of Liver Injury in Colitis Mice

et al. 2022

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Liver injury is a common complication of inflammatory bowel disease (IBD). However, the mechanisms of liver injury development are not clear in IBD patients. Gut microbiota is thought to be engaged in IBD pathogenesis. Here, by an integrated analysis of host transcriptome and colonic microbiome, we have attempted to reveal the mechanism of liver injury in colitis mice. In this study, dextran sulfate sodium (DSS) -induced mice colitis model was constructed. Liver transcriptome showed significant up- and down-regulation of pathways linked to immune response and lipid metabolism, respectively. Whilst the colon transcriptome exhibited dramatic alterations in immune response and pathways associated with cell growth and death. The microbiota of DSS-treated mice underwent strong transitions. Correlation analyses identified genes associated with liver and colon injury, whose expression was associated with the abundance of liver and gut health-related bacteria. Collectively, the results indicate that the liver injury in colitis mice may be related to the intestinal dysbiosis and host-microbiota interactions. These findings may provide new insights for identifying potential targets for the treatment of IBD and its induced liver injury.

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“…Interestingly, we observed significant variations in serum TChol and LDL, which were consistent with the findings of Rtibi et al. ( 50 ) and Zheng et al. ( 51 ).…”

Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 92%

Multi-Omics Analysis of the Gut-Liver Axis Reveals the Mechanism of Liver Injury in Colitis Mice

et al. 2022

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“…A recent study clearly exhibited the participation of oxidative stress/inammation in gastrointestinal problems such as ulcers and constipation. 50 This contribution was checked by the augmentation of intracellular ROS production, which induces damage to lipids, proteins and DNA and inammatory indicators. Iron catalyzes hydroxyl radical-mediated oxidative injury through its implication in the Fenton pathway, which leads to the reduction of this element in oxidative stress condition.…”

Section: Tv-ae Consumption Relieves and Ameliorates Oxidative And Antmentioning

confidence: 99%

The potential of Thymus vulgaris aqueous extract to protect against delayed gastric emptying and colonic constipation in rats

et al. 2019

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“…Studies have shown that chlorogenic acid has antioxidation, anti-inflammatory, and antibacterial effects, is free radical scavenging, and improves immune regulation [10–14]. Chlorogenic acid was shown to have a certain therapeutic effect on ulcerative colitis, inhibiting intestinal inflammation, weight loss, diarrhea, and colon shortening, and improving the immune regulation of intestinal microbes [15, 16]. However, the mechanism of chlorogenic acid has not been fully explored.…”

Section: Introductionmentioning

confidence: 99%

Chlorogenic Acid Attenuates Dextran Sodium Sulfate-Induced Ulcerative Colitis in Mice through MAPK/ERK/JNK Pathway

Gao

Wang

et al. 2019

BioMed Research International

148

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Objective. Observe the protective effect of chlorogenic acid on dextran sulfate-induced ulcerative colitis in mice and explore the regulation of MAPK/ERK/JNK signaling pathway. Methods. Seventy C57BL/6 mice (half males and half females) were randomly divided into 7 groups, 10 in each group: control group (CON group), UC model group (UC group), and sulfasalazine-positive control group (SASP group), chlorogenic acid low dose group (CGA-L group), chlorogenic acid medium dose group (CGA-M group), chlorogenic acid high dose group (CGA-H group), and ERK inhibitor + chlorogenic acid group (E+CGA group). The effects of chlorogenic acid on UC were evaluated by colon mucosa damage index (CMDI), HE staining, immunohistochemistry, ELISA, and Western blot. The relationship between chlorogenic acid and MAPK/ERK/JNK signaling pathway was explored by adding ERK inhibitor. Results. The UC models were established successfully by drinking DSS water. Chlorogenic acid reduces DSS-induced colonic mucosal damage, inhibits DSS-induced inflammation, oxidative stress, and apoptosis in colon, and reduces ERK1/2, p -ERK, p38, p-p38, JNK, and p-JNK protein expression. ERK inhibitor U0126 reversed the protective effect of chlorogenic acid on colon tissue. Conclusion. Chlorogenic acid can alleviate DSS-induced ulcerative colitis in mice, which can significantly reduce tissue inflammation and apoptosis, and its mechanism is related to the MAPK/ERK/JNK signaling pathway.

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Ficus carica aqueous extract alleviates delayed gastric emptying and recovers ulcerative colitis-enhanced acute functional gastrointestinal disorders in rats

Cited by 33 publications

References 49 publications

Multi-Omics Analysis of the Gut-Liver Axis Reveals the Mechanism of Liver Injury in Colitis Mice

Multi-Omics Analysis of the Gut-Liver Axis Reveals the Mechanism of Liver Injury in Colitis Mice

The potential of Thymus vulgaris aqueous extract to protect against delayed gastric emptying and colonic constipation in rats

Chlorogenic Acid Attenuates Dextran Sodium Sulfate-Induced Ulcerative Colitis in Mice through MAPK/ERK/JNK Pathway

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