Ficus capensis Thumb. (Moraceae): Review of Its Ethnomedicinal Uses, Pharmacological Activities and Phytochemical Constituents

Esievo, Kevwe Benefit; Anthony, Samuel Onuche; Fatokun, Omolola Temitope; Kunle, Olobayo O.

doi:10.9734/acri/2018/39495

Cited by 8 publications

(2 citation statements)

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“…Its leaves and roots are used to cure leukoderma, leprosy, wounds, oedema, respiratory problems, diarrhoea, sexually transmitted illnesses, tuberculosis, anaemia, epilepsy, rickets, dysentery, male infertility, and gonorrhoea in Sudan and Nigeria [ 6 ]. According to ethnobotanical research, F. sur is also used to cure swellings [ 7 ]. It has long been used in South Africa and other nations to treat renal disorders and as a natural diuretic product [ 8 , 9 ].…”

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confidence: 99%

Phytochemical Insights into Ficus sur Extracts and Their Biological Activity

et al. 2022

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This study focused on the biological evaluation and chemical characterisation of Ficus sur Forssk. (F. sur) (Family: Moraceae). The methanolic and aqueous extracts’ phytochemical profile, antioxidant, and enzyme inhibitory properties were investigated. The aqueous stem bark extract yielded the highest phenolic content (115.51 ± 1.60 mg gallic acid equivalent/g extract), while the methanolic leaves extract possessed the highest flavonoid content (27.47 ± 0.28 mg Rutin equivalent/g extract). In total, 118 compounds were identified in the tested extracts. The methanolic stem bark extract exhibited the most potent radical scavenging potential against 2,2-diphenyl-1 picrylhydrazyl and 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (475.79 ± 6.83 and 804.31 ± 4.52 mg Trolox equivalent/g extract, respectively) and the highest reducing Cu2+ capacity (937.86 ± 14.44 mg Trolox equivalent/g extract). The methanolic stem bark extract substantially depressed tyrosinase (69.84 ± 0.35 mg kojic acid equivalent/g extract), α-amylase (0.77 ± 0.01 mmol acarbose equivalent/g extract), acetylcholinesterase and butyrylcholinesterase (2.91 ± 0.07 and 6.56 ± 0.34 mg galantamine equivalent/g extract, respectively) enzymes. F. sur extracts were tested for anticancer properties and antiviral activity towards human herpes virus type 1 (HHV-1). Stem bark infusion and methanolic extract showed antineoplastic activity against cervical adenocarcinoma and colon cancer cell lines, whereas leaf methanolic extract exerted moderate antiviral activity towards HHV-1. This investigation yielded important scientific data on F. sur which might be used to generate innovative phytopharmaceuticals.

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Section: Introductionmentioning

confidence: 99%

Phytochemical Insights into Ficus sur Extracts and Their Biological Activity

et al. 2022

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“…In Sudan and Nigeria, its leaves and roots are used for treatment of leukoderma, leprosy, wounds, edema, respiratory disorders, diarrhea, sexually transmitted diseases, tuberculosis, anemia, epilepsy, rickets, dysentery, male infertility and gonorrhea. 9,10 Ethnobotanical studies also showed F. sur is used to treat swellings and edema, 11 In South Africa and other countries it is traditionally used in kidney problems and as adiuretic. 5,12 In Ethiopia, the pounded fresh leaves of F. sur, mixed with water are given orally as a traditional medication for urine retention thereby to alleviate the problem via increasing urine output.…”

Section: Introductionmentioning

confidence: 99%

<p>Evaluation of the Diuretic Activity of the Aqueous and 80% Methanol Extracts of <em>Ficus sur</em> Forssk (Moraceae) Leaves in Saline-loaded Rats</p>

Ayele¹,

Makonnen²,

Ayele³

et al. 2020

JEP

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Background Although investigations on different pharmacological activities of the experimental plant, Ficus sur have been conducted, its folklore use for diuresis has not yet been validated. The current study, therefore, focused on the diuretic activity of aqueous and 80% methanol extracts of F. sur Forssk. leaves in rats. Methods Rats were randomly assigned into eight groups each consisting of six rats. Test groups received either 100 mg/kg, 200 mg/kg, or 400 mg/kg of aqueous or 80% methanol leaves extract. The negative control group and positive control were treated with 2 mL/100 g of distilled water and furosemide (10 mg/kg), respectively. Thereafter urine volume was recorded every hour until the end of the fifth hour, and cumulative urine volume of each rat was measured. Then, diuretic activity, diuretic index, saliuretic index, natriuretic index and carbonic anhydrase inhibition index in each group were calculated, and results were compared among the groups. Results The middle (200 mg/kg) and the highest (400 mg/kg) doses of both extracts significantly increased diuresis at the fifth hour ( p <0.001) compared to the negative control, although the diuretic activity was less than that of the positive control. Regarding electrolyte excretion, all dose levels of both extracts showed significant natriuresis ( p <0.001) and chloriuresis ( p <0.01) compared to the negative control. Aqueous extract displayed more significant diuretic effect than 80% methanol extract. The aqueous and 80% methanol extracts produced alkaline urine. Conclusion The crude leaves extracts of F. sur increased urinary excretion and concentration of urinary electrolytes in a dose-dependent manner. These findings are in agreement with the traditional claim for use of F. sur as diuretic agent.

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