Fibrous wound dressings encapsulating essential oils as natural antimicrobial agents

Liakos, Ioannis; Rizzello, Loris; Hajiali, Hadi; Brunetti, Virgilio; Carzino, Riccardo; Pompa, Pier Paolo; Athanassiou, Athanassia; Mele, Elisa

doi:10.1039/c4tb01974a

Cited by 151 publications

(93 citation statements)

References 33 publications

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“…Although, silver (Ag) nanoparticles have been blended into electrospun zein fibers to achieve antibacterial properties, [ 25 ] it is believed that use of natural medicinal extracts such as essential oils can further boost pharmaceutical applications and in vivo patient care due to their low toxicity and broad spectrum antimicrobial activities. [ 26–32 ]…”

Section: Introductionmentioning

confidence: 99%

In Situ Electrospinning Wound Healing Films Composed of Zein and Clove Essential Oil

Qin

Mou

Dong

et al. 2020

Macro Materials & Eng

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Electrospun fibrous membranes have the potential to be effective wound dressings for promoting wound healing. However, the fabrication and application of the common electrospun fibrous wound dressings are usually complicated and separated. Here, electrospun zein/clove essential oil (CEO) fibrous membranes are fabricated and applied as a potential wound dressing through in situ electrospinning process by a portable electrospinning device. The in situ electrospinning process can directly electrospin zein/CEO membranes onto a wound site to cover the wound well and improve the convenience and comfort in use. The as‐spun zein/CEO membranes show a porous structure and exhibit higher gas permeability at 168.2 ± 43.3 mm s−1, with superhydrophilicity to absorb the wound exudate and good biocompatibility as well as antibacterial effects to protect from infection. Moreover, the mice wound model study suggests that in situ electrospun zein/CEO promotes the wound healing process.

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Section: Introductionmentioning

confidence: 99%

In Situ Electrospinning Wound Healing Films Composed of Zein and Clove Essential Oil

Qin

Mou

Dong

et al. 2020

Macro Materials & Eng

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“…In addition, it can be used in me-dicine for controlled release of active components due to its biocompatibility [3]. A number of reports have been published on utilization of CA fibers with antimicrobial substances for application as wound dressings [4,5] as well as on CA films prepared by the solvent casting method intended to be used for food packaging [1,6,7] with or without addition of antimicrobial substances. Antimicrobial active packaging can reduce the rate of microbial growth, increase the lag phase and/or inactivate microorganisms present in the target food or on the package itself [6].…”

Section: Introductionmentioning

confidence: 99%

Impregnation of cellulose acetate films with carvacrol using supercritical carbon ioxide

Adamovic¹,

Milovanović²,

Marković³

et al. 2018

Tehnika

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“…The cell viability was evaluated by well‐known MTT assay method by utilizing the L929 mouse fibroblast cell. As the fibroblasts are foremost in the rejuvenation of impaired tissues and assists wound healing, the mouse fibroblast cells were preferred for analysis. The cell viability expressed by O‐Cmc, O‐Cmc/ZnO and O‐Cmc/ZnO/Ln NCs in terms of percentage was shown in Figure .A.…”

Section: Resultsmentioning

confidence: 99%

Preparation and In Vitro Biological Evaluation of Lawsone Loaded O‐Carboxymethyl Chitosan/Zinc Oxide Nanocomposite for Wound‐Healing Application

Sakthiguru

Sithique

2020

ChemistrySelect

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A biopolymer based nanocomposite with O‐Carboxymethyl chitosan (O‐Cmc), nano zinc oxide (ZnO) and Lawsone (Ln) with proving advantages in antibacterial wound healing application was prepared. The physiochemical characteristics of the nanocomposite (NCs) was analysed by Fourier Transmission Infrared spectroscopy (FT‐IR), X‐Ray Diffractometer (XRD), Scanning electron Microscopy (SEM), Transmission electron microscope (TEM) and Thermogravimetric analysis (TGA). The biological properties such as anti‐inflammatory, anti‐oxidant activities were investigated in vitro. The nanocomposite also possesses efficient drug encapsulation and releasing profile with greater stability in phosphate buffer saline (PBS) and Dulbecco's minimal essential medium (DMEM). The results of the antibacterial studies show its enhanced bactericidal nature. The results obtained from MTT assay, Ethidium bromide stained fluorescence image and in vitro wound scratch assay show greater cell viability with the closure of scratch wound obviously proves it′s prominent biocompatible, wound closure nature. These biological properties show that the prepared nanocomposite has a greater potential to act as an excellent biomaterial in the field of wound care applications.

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Fibrous wound dressings encapsulating essential oils as natural antimicrobial agents

Abstract: Essential oils with high antibiotic activity were incorporated into cellulose acetate natural polymer. By using the electrospinning technique, nanofibrous matrices were prepared to be used as effective antimicrobial wound dressings.

Cited by 151 publications

References 33 publications

In Situ Electrospinning Wound Healing Films Composed of Zein and Clove Essential Oil

In Situ Electrospinning Wound Healing Films Composed of Zein and Clove Essential Oil

Impregnation of cellulose acetate films with carvacrol using supercritical carbon ioxide

Preparation and In Vitro Biological Evaluation of Lawsone Loaded O‐Carboxymethyl Chitosan/Zinc Oxide Nanocomposite for Wound‐Healing Application

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