Fibrous tissue armoring increases the mechanical strength of an impacted bone graft

Tägil, Magnus; Aspenberg, Per

doi:10.1080/000164701753606743

Cited by 46 publications

(22 citation statements)

References 20 publications

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“…From human cadaver studies, we know that allografted implants can be anchored in an inert composite of graft chips and fibrous tissue (Linder 2000). Some experiments have suggested that such a composite of fibrous tissue and allograft may be a mechanism that is sufficient for anchorage of an implant (Tägil and Aspenberg 2001). Our results indicate that bone ingrowth further strengthens the β-TCP granules by forming a bridge between the existing bone and the graft material, as well as between the graft granules.…”

Section: Discussionsupporting

confidence: 60%

Ceramic bone graft substitute with equine bone protein extract is comparable to allograft in terms of implant fixation: A study in dogs

et al. 2008

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Background and purpose We studied whether osseointegration and fixation of plasma-sprayed titanium implants grafted with β-TCP granules (Ossaplast) can be improved by adding an osteogenic signal (Colloss E). The results were compared to implants grafted with fresh frozen morselized allograft with and without the Colloss E device.Methods 4 porous-coated Ti implants were placed in the proximal humeri in each of 10 dogs. All implants were surrounded by a 2.5-mm defect, which was grafted with: (A) β-TCP, (B) β-TCP + 20 mg Colloss E, (C) allograft, or (D) allograft + 20 mg Colloss E. The observation time was 4 weeks.Results Mechanical testing showed that the β-TCP group with Colloss E was twice as well fixed as the control group grafted with β-TCP granules alone, and comparable to both allograft groups. We found that every control implant in the β-TCP grafted group was covered by a dense fibrous membrane. No fibrous tissue was seen in the β-TCP group augmented with Colloss. These implants were well osseointegrated, with new bone covering 10-25% of the implant surface. Both treated groups had increased graft resorption compared to their respective control groups. Colloss E had no effect on new bone formation or fibrous tissue reduction around the allografted implants.Interpretation The Colloss E device improved early osseointegration of implants grafted with β-TCP granules and increased their mechanical implant fixation to the level of allografted implants. The experiment

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Section: Discussionsupporting

confidence: 60%

Ceramic bone graft substitute with equine bone protein extract is comparable to allograft in terms of implant fixation: A study in dogs

et al. 2008

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“…Other experimental studies have shown that impaction inhibits the growth of new bone into the allograft (Tägil and Aspenberg 1998). Although one would presume that new bone growth into the graft material is better than fibrous tissue, it has also been suggested that infiltration of fibrous tissue increases the mechanical strength of impacted allograft pending remodeling (Tägil and Aspenberg 2001). The osteoinductive properties of demineralized bone matrix were described by Urist in the 1960s (Urist 2002).…”

Section: Discussionmentioning

confidence: 98%

The bovine bone protein lyophilisate Colloss improves fixation of allografted implants—an experimental study in dogs

et al. 2006

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Background Impacted morselized bone allograft is a well-established way of giving joint arthroplasties additional support in situations where there is insufficient bone stock. For long-term survival of the implant, early implant fixation is important. We hypothesized that Colloss, a bone protein lyophilisate, might improve early implant fixation of allografted implants.Method We inserted 4 porous-coated Ti implants in the distal femurs of 16 dogs. All implants were surrounded by a 2.5-mm gap, which was impacted with morselized allograft with or without Colloss. In each dog, the implants were treated with no Collos or low-, middle-or high-dose (0, 10, 20 and 40 mg) Colloss per cm 3 allograft. The observation time was 4 weeks.Results Mechanical implant fixation was improved for all 3 groups with Colloss-treated implants (p < 0.05). The best anchorage was seen in the middle-dose group, where fixation was improved by 100%. We saw a dramatic reduction in fibrous tissue on the surface of the Colloss-treated implants (p < 0.001). The Colloss groups showed increased ongrowth of new bone (p < 0.01) and accelerated gap remodeling (p < 0.05).Interpretation Colloss can improve early osseointegration and fixation of allografted implants.

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“…Ingrown fibrous tissue usually supports the graft fragments and forms a mechanically stable composite which, after a brief initial period of remodeling, remains inert (Linder 2000). This fibrous tissue cover con- tributes to the mechanical properties of the graft (Tägil and Aspenberg 2001). Bisphosphonates adsorb to bone and inactivate osteoclasts when the bone is resorbed (Russell and Rogers 1999).…”

Section: Discussionmentioning

confidence: 99%

A combination of bisphosphonate and BMP additives in impacted bone allografts

Jeppsson

Åstrand

Tägil

et al. 2003

Acta Orthopaedica Scandinavica

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Fibrous tissue armoring increases the mechanical strength of an impacted bone graft

Cited by 46 publications

References 20 publications

Ceramic bone graft substitute with equine bone protein extract is comparable to allograft in terms of implant fixation: A study in dogs

Ceramic bone graft substitute with equine bone protein extract is comparable to allograft in terms of implant fixation: A study in dogs

The bovine bone protein lyophilisate Colloss improves fixation of allografted implants—an experimental study in dogs

A combination of bisphosphonate and BMP additives in impacted bone allografts

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