Fibrous Nanozyme Dressings with Catalase-Like Activity for H<sub>2</sub>O<sub>2</sub> Reduction To Promote Wound Healing

Hu, Minghan; Korschelt, Karsten; Daniel, Phillip; Landfester, Katharina; Tremel, Wolfgang; Bannwarth, Markus B.

doi:10.1021/acsami.7b12212

Cited by 119 publications

(88 citation statements)

References 45 publications

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“…Various nanozyme based applications have been extensively explored, including in vitro and in vivo biosensors, and antibacterial and disease therapies, such as cancer theranostics, bone marrow therapy, and wound healing . In addition, environmental protection is also an important area.…”

Section: Applications Of Nanozymesmentioning

confidence: 99%

Recent Advances in Nanozyme Research

2018

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inflammatory response to combat infections and can also react with many important biomolecules including proteins, lipids, and nucleic acid polymers (RNA and DNA). [7] Low dosage of ROS plays important roles in signal transduction, cell proliferation/migration/differentiation, and body defense against pathogen invasion. However, abnormally elevated ROS level can destroy redox homeostasis and cause oxidative stress and serious damage of structure and function of macromolecules in the cell. Research during the last decade has shown that oxidative stress could lead to diseases such as chronic inflammation and eventually diabetes, cancer, as well as cardiovascular, neurological, and pulmonary diseases. [8] Enzyme systems (e.g., superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase) are responsible for protecting cells from the detrimental effects of ROS by modulating the intracellular ROS level.Nanozyme can also modulate the ROS level in cells (Figure 2). [9] The ROS scavenging abilities of nanozymes largely originate from the SOD mimicking activities, which convert superoxide into H 2 O 2 and subsequently to O 2 and H 2 O, and thus reduce the intracellular ROS level and enhance cell viability. The generation of ROS originates from their peroxidases (POD) activities, which convert H 2 O 2 to OH· radicals, and oxidase activities, which convert O 2 to H 2 O 2 . Outside the cell, ROS can react with biologically active molecules (such as glucose, dopamine, glutathione, and adenosine triphosphate), organic compound (such as phenol and dyes), and pollutants from aqueous solutions. Thus the nanozymes could play important roles in in vitro test and environmental protection. [10] Earlier reports on nanozymes mainly focused on the aspect of experimental study and rarely focused on the theoretical work and mechanism clarification. In this progress report, we first introduce various nanozymes and highlight recent experimental development of new nanozymes that have been investigated to mimic various enzymes. Then we review their applications in various fields including biosensing, bioimaging, therapeutics, and environmental protection. At last, we summarize the catalytic mechanisms and address the challenges of experimental and computational research in this field. The Structure of NanozymesIssues of material design for high catalytical activity, selectivity, and durability are recently accentuated. Among them As a new generation of artificial enzymes, nanozymes have the advantages of high catalytic activity, good stability, low cost, and other unique properties of nanomaterials. Due to their wide range of potential applications, they have become an emerging field bridging nanotechnology and biology, attracting researchers in various fields to design and synthesize highly catalytically active nanozymes. However, the thorough understanding of experimental phenomena and the mechanisms beneath practical applications of nanozymes limits their rapid development. Herein, the progress of experimental and computational...

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Section: Applications Of Nanozymesmentioning

confidence: 99%

Recent Advances in Nanozyme Research

2018

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“…Hu and co-workers used IO-NPs in wound dressings made of poly(vinyl alcohol) (PVA) membranes fabricated via electrospinning [173]. A polymeric PVA mesh was chosen as the scaffold due to the high surface-to-volume ratio and porosity, which allow for high water absorption and strong oxygen permeation [176].…”

Section: Wound Healingmentioning

confidence: 99%

Cerium- and Iron-Oxide-Based Nanozymes in Tissue Engineering and Regenerative Medicine

Jansman

Hosta‐Rigau

2019

Catalysts

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Nanoparticulate materials displaying enzyme-like properties, so-called nanozymes, are explored as substitutes for natural enzymes in several industrial, energy-related, and biomedical applications. Outstanding high stability, enhanced catalytic activities, low cost, and availability at industrial scale are some of the fascinating features of nanozymes. Furthermore, nanozymes can also be equipped with the unique attributes of nanomaterials such as magnetic or optical properties. Due to the impressive development of nanozymes during the last decade, their potential in the context of tissue engineering and regenerative medicine also started to be explored. To highlight the progress, in this review, we discuss the two most representative nanozymes, namely, cerium- and iron-oxide nanomaterials, since they are the most widely studied. Special focus is placed on their applications ranging from cardioprotection to therapeutic angiogenesis, bone tissue engineering, and wound healing. Finally, current challenges and future directions are discussed.

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“…While high ROS concentrations prohibit healing, a good inflow of O 2 to the wound is desired. Electrospun cross‐linked poly(vinyl alcohol) (PVA) membranes containing integrated hematite NPs contemptuously reduce H 2 O 2 and increase O 2 levels . The high water permeability of the porous PVA membrane and the catalase‐like activity of embedded hematite nanoparticles can efficiently convert H 2 O 2 into O 2 as shown by a catalase assay.…”

Section: Nanozymes As Ros Scavengers For Biomedical Applicationsmentioning

confidence: 99%

A Step into the Future: Applications of Nanoparticle Enzyme Mimics

Korschelt

Tahir

Tremel

2018

Chemistry A European J

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We describe elementary concepts, up-to-date developments, and perspectives of the emerging field of nanoparticle enzyme mimics (so-called "nanozymes") at the interface of chemistry, biology, materials, and nanotechnology. The design and synthesis of functional enzyme mimics is a long-standing goal of biomimetic chemistry. Metal complexes, polymers and engineered biomolecules capturing the structure of natural enzymes or their active centers have been made to achieve high rates and enhanced selectivities. Still, the design of new "artificial enzymes" that are not related to proteins but with capacity of production and stability at industrial level, remains a goal. Inorganic nanoparticles bear this potential. Although it seems counterintuitive to compare nanoparticles and natural enzymes because they appear very different they share many common features: nano-size, irregular shape, and rich surface chemistry. These features enable nanomaterials to mimic reactions of natural enzymes. Representative examples with biomedical and environmental applications are given.

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Fibrous Nanozyme Dressings with Catalase-Like Activity for H₂O₂ Reduction To Promote Wound Healing

Cited by 119 publications

References 45 publications

Recent Advances in Nanozyme Research

Recent Advances in Nanozyme Research

Cerium- and Iron-Oxide-Based Nanozymes in Tissue Engineering and Regenerative Medicine

A Step into the Future: Applications of Nanoparticle Enzyme Mimics

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Fibrous Nanozyme Dressings with Catalase-Like Activity for H2O2 Reduction To Promote Wound Healing

Cited by 119 publications

References 45 publications

Recent Advances in Nanozyme Research

Recent Advances in Nanozyme Research

Cerium- and Iron-Oxide-Based Nanozymes in Tissue Engineering and Regenerative Medicine

A Step into the Future: Applications of Nanoparticle Enzyme Mimics

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Product

Resources

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Fibrous Nanozyme Dressings with Catalase-Like Activity for H₂O₂ Reduction To Promote Wound Healing